Emodepside and SL0-1 potassium channels: A review

Martin, R. J.; Buxton, Samuel; Neveu, Cédric; Charvet, Claude; Robertson, Alan P.

doi:10.1016/j.exppara.2011.08.012

Cited by 37 publications

(33 citation statements)

References 45 publications

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“…A SLO-1 K + channel ( C ) is shown composed of 4 subunits along with the ‘RCK’ cytoplasmic regulatory region of the channel. (Martin et al, 2012)…”

Section: Figmentioning

confidence: 99%

“…Emodepside increased L K currents at 10 min (p < 0.01, n = 4, paired t-test ), 20 min (p < 0.01, n = 4, paired t-test ) and 30 min (p < 0.05, n = 4, paired t-test ). (Martin et al, 2012)…”

Section: Figmentioning

confidence: 99%

“…However, 1 µM staurosporine decreased the hyperpolarization caused by 1 µM emodepside (p < 0.05, unpaired t-test ). (Martin et al, 2012)…”

Section: Figmentioning

confidence: 99%

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Anthelmintics: The best way to predict the future is to create it

Martin

Verma

Choudhary

et al. 2015

Veterinary Parasitology

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‘The best way to predict the future is to create it.’ When we look at drugs that are used to control parasites, we see that new knowledge has been created (discovered) about their modes of action. This knowledge will allow us to predict combinations of drugs which can be used together rationally to increase the spectrum of action and to slow the development of anthelmintic resistance. In this paper we comment on some recent observations of ours on the modes of action of emodepside, diethylcarbamazine and tribendimidine. Emodepside increases the activation of a SLO-1 K+ current inhibiting movement, and diethylcarbamazine has a synergistic effect on the effect of emodepside on the SLO-1 K+ current, increasing the size of the response. The combination may be considered for further testing for therapeutic use. Tribendimidine is a selective cholinergic nematode B-subtype nAChR agonist, producing muscle depolarization and contraction. It has different subtype selectivity to levamisole and may be effective in the presence of some types of levamisole resistance. The new information about the modes of action may aid the design of rational drug combinations designed to slow the development of resistance or increase the spectrum of action.

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“…A SLO-1 K + channel ( C ) is shown composed of 4 subunits along with the ‘RCK’ cytoplasmic regulatory region of the channel. (Martin et al, 2012)…”

Section: Figmentioning

confidence: 99%

“…Emodepside increased L K currents at 10 min (p < 0.01, n = 4, paired t-test ), 20 min (p < 0.01, n = 4, paired t-test ) and 30 min (p < 0.05, n = 4, paired t-test ). (Martin et al, 2012)…”

Section: Figmentioning

confidence: 99%

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Anthelmintics: The best way to predict the future is to create it

Martin

Verma

Choudhary

et al. 2015

Veterinary Parasitology

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“…However, the sequence of events in this case requires further clarification. It is also assumed (79) that, along with the described, this involves a minor participation of a slow-acting signaling mechanism (involving latrophilin-like receptor of presynapse and G qprotein) (78,79).…”

Section: +mentioning

confidence: 99%

EVOLUTION IN CHEMOTHERAPY OF HUMAN AND ANIMAL HELMINTHIASES (review)

Джафаров¹

2013

S-h. biol.

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S u m m a r yThe attention is focused on the main classes of anthelmintics. Mode of action of the anthelmintics and the anthelmintic resistance, and alternative methods for dehelminthization are discussed. A targeted search for new anthelmintic substances in the series of speculative parental hydrocarbons (benzene, indene, naphthalene, 1 H1-cyclopenta [a]-naphthalene and phenanthrene) is suggested to be prospective on the basis of variation in their structure from the fully unsaturated to saturated forms, including those containing heteroatoms (N, O, S), various functional groups and substituents:

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“…Studies on the mode of action suggest that emodepside targets the calcium-activated potassium channel (SLO-1), there is also evidence for the involvement of the latrophilin (LAT-1) receptor [78–80]. Mutagenesis screens in C. elegans revealed a lack of sensitivity of slo-1 null mutants to emodepside’s inhibitory effects on locomotion and feeding.…”

Section: Introductionmentioning

confidence: 99%

A brief review on the mode of action of antinematodal drugs

2017

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Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since resistance development appears almost inevitable, there is a continued and pressing need to fully understand the mode of action of these compounds. It is also necessary to identify new drug targets and drugs for the continued effective control of nematode parasites.

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Emodepside and SL0-1 potassium channels: A review

Cited by 37 publications

References 45 publications

Anthelmintics: The best way to predict the future is to create it

Anthelmintics: The best way to predict the future is to create it

EVOLUTION IN CHEMOTHERAPY OF HUMAN AND ANIMAL HELMINTHIASES (review)

A brief review on the mode of action of antinematodal drugs

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