emm type diversity of β-haemolytic streptococci recovered in Chennai, India

Menon, Thangam; Lloyd, Charmaine; Malathy, B.; Sakota, Varja; Jackson, Delois; Beall, Bernard

doi:10.1099/jmm.0.47726-0

Cited by 12 publications

(9 citation statements)

References 17 publications

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“…The prevalence of emm types stG485.0 and stG166b was even higher in the invasive group (23.2 % and 16.2 %, respectively). These results are in accordance with other studies: emm types stG485.0 and stG6.1 were reported as being the most common types identified among patients with group G bacteremia in a hospital setting in Jerusalem [6], in Chennai, south India [16] and in a hospital setting in Northern Taiwan [17]. The total high prevalence of those emm types in all other isolates (noninvasive and carriage) indicates the likelihood of a possible reservoir for severe infections.…”

Section: Discussionsupporting

confidence: 93%

Molecular characterization and antibiotic resistance of group G streptococci in Israel: comparison of invasive, non-invasive and carriage isolates

Halperin

Levine

Korenman

et al. 2016

Eur J Clin Microbiol Infect Dis

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Beta-hemolytic group G streptococci (GGS) are increasingly recognized as a source of substantial morbidity, causing mild to severe sporadic infections as well as outbreaks. The purpose of this study was to determine the genetic diversity and antibiotic resistance of GGS in Israel in order to aid in prevention and control. A total of 325 GGS isolates were collected in Israel between 2007 and 2011 from three determined settings: (1) carriage (n = 60), an observational longitudinal carriage study in the IF, (2) non-invasive (n = 166), clinical sporadic and epidemic non-invasive cases in the IDF, and (3) invasive (n = 99) cases of bacteremia collected during this period in Israel from a similar age group, at the national Streptococcal Reference Center. All isolates were characterized genetically and by their antibiotic-resistance profile. emm typing revealed 35 distinct types and subtypes among 228 S. dysgalactiae subsp. equisimilis (SDSE) isolates, with high genetic diversity. An additional 97 GGS were identified as Streptococcus anginosus (SAG). The proportion of SDSE was higher in the invasive (100 %) and non-invasive (63.8 %) isolates compared to the carriage ones (38.3 %). Clindamycin, erythromycin, azithromycin and tetracycline resistance was detected in 6.6 %, 8.6 %, 9.7 % and 37.6 % of isolates, respectively. Overall, the most resistant isolates were in the invasive group and the fewest were in the SAG group. Considerable genetic diversity and common antibiotic resistance were revealed among GGS strains which differed according to the epidemiologic settings. Further clinical, epidemiological and basic research of GGS as a pathogen is warranted.

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Section: Discussionsupporting

confidence: 93%

Molecular characterization and antibiotic resistance of group G streptococci in Israel: comparison of invasive, non-invasive and carriage isolates

Halperin

Levine

Korenman

et al. 2016

Eur J Clin Microbiol Infect Dis

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“…17,18 In addition, although M proteins are present in non-GBS BHS [Group C Streptococcus (GCS)/Group G Streptococcus (GGS)], they are diverse, rendering a broadly protective M-based approach challenging. [19][20][21] Therefore, other approaches for development of a broadly protective vaccine have been considered. 22 One of a number of promising vaccine candidates is the recombinant streptococcal C5a peptidase (SCP) antigen, 23 which is conserved across BHS, and has shown preclinical efficacy against GAS and GBS.…”

mentioning

confidence: 99%

Group A Streptococcal Carriage and Seroepidemiology in Children up to 10 Years of Age in Australia

Marshall

Richmond

Nissen

et al. 2015

Pediatric Infectious Disease Journal

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“…Reported literature on emm distribution among Indian GAS isolates is relatively limited (Dey et al 2005;Sagar et al 2004;Sindhulina et al 2008;Menon et al 2001Menon et al , 2008; however, a comparison of these studies shows that distinct differences do exist among the types identified among GAS isolated from Bangalore, Chennai and Chandigarh. Interestingly, types 12, 49, 71, 74 and to some extent type 1 are common to the above regions.…”

Section: Resultsmentioning

confidence: 97%

Prevalence of emm types of Group A streptococci recovered from school children and hospital patients in Bangalore City, India

Gowda

Melbin

Patil

et al. 2010

World J Microbiol Biotechnol

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A total of sixty non repetitive isolates of group A streptococci (GAS) recovered from throat cultures of asymptomatic school children (n = 36), school children with clinical pharyngitis (n = 9) and hospital patients with clinical pharyngitis (n = 4) as well as diverse clinical samples from invasive GAS disease (n = 11) were subjected to emm typing. A total of 35 emm types including 3 new subtypes were identified among them. Types emm 12 (16.6%) and emm 71 (6.6%) were the most prevalent. The distribution of emm types identified among school children were similar to those encountered among invasive isolates but was significantly different from those reported elsewhere in India. Our study confirms the high diversity among Indian GAS isolates as well as significant regional differences among the distribution of emm types.

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emm type diversity of β-haemolytic streptococci recovered in Chennai, India

Abstract: JMM Correspondence emm type diversity of b-haemolytic streptococci recovered in Chennai, India

Cited by 12 publications

References 17 publications

Molecular characterization and antibiotic resistance of group G streptococci in Israel: comparison of invasive, non-invasive and carriage isolates

Molecular characterization and antibiotic resistance of group G streptococci in Israel: comparison of invasive, non-invasive and carriage isolates

Group A Streptococcal Carriage and Seroepidemiology in Children up to 10 Years of Age in Australia

Prevalence of emm types of Group A streptococci recovered from school children and hospital patients in Bangalore City, India

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