Energy management and vehicle fuel economy are important automotive development drivers besides ambient emissions. Many technologies and solutions are being proposed, compared and improved. Any solution demands expensive resources to be tested and sometimes even the most accurate experimental arrangement is not enough to prove its effectiveness. In this scenario numerical simulation represents an important and reliable tool to make sure even very small improvements, very difficult to be measured, could be honestly compared. Considering that a vehicular solution could be more efficient depending on drive cycle this paper compares, by numerical simulations, the impact of vehicle powertrain plus driving conditions on a passenger car fuel economy. From powertrain side different transmissions, manual (5 and 6 speed) and automatic (6 speed: dual clutch, torque converter and CVT), are compared. From driving conditions side different test cycles (FTP75, HWY, NEDC and WLTC) and vehicle loads (unloaded 1000 kg vehicle and loaded 1500 kg vehicle) are compared.