Emission tomography in embolic lung disease: Angiographic correlations

Donaldson, Robert M.; Kahn, Otto Hermann; Raphaël, Maurice; Jarritt, P. H.; Ell, Peter J.

doi:10.1016/s0009-9260(82)80304-8

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…Some observed that SPECT showed mismatches (21), particularly subsegmental mismatches (34,35), more clearly than did planar V/Q imaging. Sensitivity was thought to be higher with SPECT than with conventional V/Q imaging (36), and review of 5 investigations supported this impression (2,19,20,22,23).…”

Section: Comparisons Of Spect With Planar V/q Imagingmentioning

confidence: 99%

SPECT in Acute Pulmonary Embolism

Stein¹,

Freeman²,

Sostman³

et al. 2009

J Nucl Med

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The purpose of this review was to evaluate the accuracy of SPECT in acute pulmonary embolism. Sparse data are available on the accuracy of SPECT based on an objective reference test. Several investigations were reported in which the reference standard for the diagnosis of pulmonary embolism was based in part on the results of SPECT or planar ventilation-perfusion (V/Q) imaging. The sensitivity of SPECT in all but one investigation was at least 90%, and specificity also was generally at least 90%. The sensitivity of SPECT in 4 of 5 investigations was higher than that of planar V/Q imaging. The specificity of SPECT was generally higher, equal, or only somewhat lower than that of planar V/Q imaging. Most investigators reported nondiagnostic SPECT V/Q scans in no more than 3% of cases. Methods of obtaining SPECT images, methods of obtaining planar V/Q images, and the criteria for interpretation varied. The general impression is that SPECT is more advantageous than planar V/Q imaging.

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Section: Comparisons Of Spect With Planar V/q Imagingmentioning

confidence: 99%

SPECT in Acute Pulmonary Embolism

Stein¹,

Freeman²,

Sostman³

et al. 2009

J Nucl Med

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“…Our unpublished, clinical experience has shown that detection of perfusion defects in neighboring segments is especially difficult with routine planar imaging after lung transplantation. SPECT employs standard radiopharmaceuticals and current imaging equipment, thereby requiring few additional expenditures for a nuclear medicine department, and it is widely used in both experimental and clinical pulmonary vascular research (44,45). Other potential advantages over conventional gamma-camera imaging include (46,47) (1) possibility for qualitative study of the pulmonary circulation on coronal, sagittal, and transaxial views, (2) capacity to separate radionuclide activity in front of and behind target areas, (3) improvement of total volume imaging and contrast, (4) more precise detection and localization of small defects, and (5) capacity for three-dimensional localization of radiopharmaceutical distribution and cinematic representation of lung imaging.…”

Section: Discussionmentioning

confidence: 99%

Comparison of SPECT lung perfusion with transbronchial lung biopsy after lung transplantation.

Colt

Cammilleri²,

Khelifa³

et al. 1994

Am J Respir Crit Care Med

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The objective of this study was to evaluate the potential role for single photon-emission computed tomography (SPECT) using technetium 99m-macroaggregated albumin for diagnosing rejection in lung transplant patients. SPECT results were compared with those obtained from transbronchial biopsy (TBB) in patients undergoing bronchoscopy during routine surveillance and in cases of clinical, radiographic, or physiologic suspicion of lung rejection. This prospective, nonrandomized study was conducted by the Marseille Lung Transplant Group, Marseille University Hospitals South. It included 26 lung transplant recipients (19 double-lung, four single-lung, and three heart-lung). For each patient, SPECT lung perfusion was performed before TBB as part of routine surveillance protocol and when clinically indicated. Routine surveillance included TBB at 1, 3, 6, 9, and 12 months and every 6 months thereafter. SPECT was always performed within the 24 h preceding TBB. Whenever the SPECT was abnormal, biopsies were obtained from an area corresponding to a region of hypoperfusion. Results of the study were based on 79 paired SPECT and TBB obtained from 26 patients. Concordance between SPECT and biopsy occurred in 71 instances (89.9%). Among 25 cases of normal SPECT, TBB was normal in 24 and revealed subclinical lung rejection in one. Among 54 cases of abnormal SPECT, TBB was also abnormal in 47 (87.0%), with lung rejection being the abnormality in 23 (46%). For pairs performed as part of the routine surveillance protocol (61 pairs), clinically silent lung rejection was diagnosed in 16 (26.2%). SPECT was abnormal in 15 of 16 instances and normal in only one; this patient had minimal rejection that resolved without treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Although one author finds the studies confusing, 36 others have found them potentially very useful for evaluating suspected PE and other diseases affecting pulmonary perfusion. 37 ' 38 The technique offers the possibility of accurate quantitation of blood flow in various regions of the lung. This topic is explored more fully in another article in this issue.…”

Section: Other Techniquesmentioning

confidence: 99%

Radionuclide Studies in Lung Disease

Sullivan¹

1983

Semin Respir Crit Care Med

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Emission tomography in embolic lung disease: Angiographic correlations

Cited by 9 publications

References 4 publications

SPECT in Acute Pulmonary Embolism

SPECT in Acute Pulmonary Embolism

Comparison of SPECT lung perfusion with transbronchial lung biopsy after lung transplantation.

Radionuclide Studies in Lung Disease

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