<p><strong>Abstract.</strong> A long-term historical emission inventory of air and climate pollutants in East, Southeast, and South Asia from 1950&#8211;2015 was developed as the Regional Emission inventory in ASia version 3.1 (REASv3.1). REASv3.1 provides details of emissions from major anthropogenic sources for each country and its sub-regions and also provides monthly gridded data with 0.25&#176;&#8201;&#215;&#8201;0.25&#176; resolution. The average total emissions in Asia during 1950&#8211;1955 and from 2010&#8211;2015 (growth rates in these 60 years) are as follows: SO<sub>2</sub>: 3.15&#8201;Tg, 42.4&#8201;Tg (13.5); NO<sub>x</sub>: 1.83&#8201;Tg, 47.6&#8201;Tg (26.0); CO: 62.2&#8201;Tg, 319&#8201;Tg (5.13); non-methane volatile organic compounds: 9.14&#8201;Tg, 61.8&#8201;Tg (6.77); NH<sub>3</sub>: 7.99&#8201;Tg, 31.3&#8201;Tg (3.92); CO<sub>2</sub>: 1.12&#8201;Pg, 18.3&#8201;Pg (16.3); PM<sub>10</sub>: 5.76&#8201;Tg, 28.4&#8201;Tg (4.92); PM<sub>2.5</sub>: 4.52&#8201;Tg, 20.3&#8201;Tg (4.50); black carbon: 0.751&#8201;Tg, 3.38&#8201;Tg (4.51); and organic carbon: 2.62&#8201;Tg, 6.92&#8201;Tg (2.64). Clearly, all the air pollutant emissions in Asia increased significantly during these six decades, but situations were different among countries and regions. Due to China's rapid economic growth in recent years, its relative contribution to emissions in Asia has been the largest. However, most pollutant species reached their peaks by 2015 and the growth rates of other species was found to be reduced or almost zero. On the other hand, air pollutant emissions from India showed an almost continuous increasing trend. As a result, the relative ratio of emissions of India to that of Asia have increased recently. The trend observed in Japan was different from the rest of Asia. In Japan, emissions increased rapidly during 1950s&#8211;1970s, which reflected the economic situation of the period; however, most emissions decreased from their peak values, which were approximately 40 years ago, due to the introduction of regulations and laws for air pollution. Similar features were found in the Republic of Korea and Taiwan. In the case of other Asian countries, air pollutant emissions generally showed an increase along with economic growth and motorization. Trends and spatial distribution of air pollutants in Asia are becoming complicated. Datasets of REASv3.1, including table of emissions by countries and sub-regions for major sectors and fuel types, and monthly gridded data with 0.25&#176;&#8201;&#215;&#8201;0.25&#176; resolution for major source categories are available through the following URL: <a href=" http://www.nies.go.jp/REAS/"target="_blank">http://www.nies.go.jp/REAS/</a>.</p>