Emission failure due to retroperitoneal lymphadenectomy: first report of a pregnancy after insemination of spermatozoa obtained by midodrin-induced retrograde ejaculation

Schill, W.‐B.; Bollmann, W.

doi:10.1007/978-94-009-4898-3_35

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…One of these seven patients had partial retrograde ejaculation and three had complete retrograde ejaculation. Schill & Bollmann (1984) were the first who reported of a pregnancy after treatment with midodrin. Their patient had suffered from emission failure after retroperitoneal lymphadenectomy.…”

Section: Discussionmentioning

confidence: 99%

The alpha-sympathomimetic midodrin as a tool for diagnosis and treatment of sperm transport disturbances

Köhn

Schill

2009

Andrologia

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The present study was performed to determine the usefulness of the alphasympathomimetic midodrin for diagnosis and treatment of functional sperm transport disturbances. 140 andrological patients consulting due to severe oligozoospermia, hypospermia or partial/ complete retrograde ejaculation were included. Ejaculates were examined 30 min after intravenous injection of 5-15 mg midodrin. Sperm concentration, motility and alpha-glucosidase as a marker of both epididymal function and sufficient passage through the uusa deferentia and the ejaculatory duct were measured and the values compared to those in the ejaculates obtained before therapy. In 23 of 140 patients, sperm concentration or total sperm count was improved by more than 10 million spermatozoa ml -' or 20 million spermatozoa per ejaculation. Alpha-glucosidase in the seminal plasma increased in two cases. The present study demonstrates that severe oligozoospermia may be caused by functional transport disturbance of semen from the epididymis to the efferent duct system. In these cases, midodrin is of diagnostic and therapeutic value; however, it should be emphasized that its effectiveness cannot be predicted individually.

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Section: Discussionmentioning

confidence: 99%

The alpha-sympathomimetic midodrin as a tool for diagnosis and treatment of sperm transport disturbances

Köhn

Schill

2009

Andrologia

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Grossesse apres Fecondation In Vitro dans un cas d’ejaculation seche (absence d’emission) partiellement ameliore par traitement pharmacologique

Buvat

Marcolin

Buvat-Herbaut

et al. 1991

Androl.

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PREGNANCY FOLLOWING IN VITRO FERTILIZATION IN A CASE OF EMISSION FAILURE ONLY PARTLY IMPROVED BY PHARMACOLOGICAL TREATMENT. To date only 3 pregnancies have been reported following treatment of emission failure. We report the fourth one obtained from a male with an history of retroperitoneal lymphadenectomy. Pharmacological treatment induced antegrade ejaculation of a small semen drop wich was unsuccessfully inseminated during 15 cycles. In Vitro Fertilization (IVF) obtained a good fertilization rate and full-term twin pregnancy at the third attempt. IVF clearly widens the possibility of treating infertility in case of failure of ejaculation.

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Emission failure due to retroperitoneal lymphadenectomy: first report of a pregnancy after insemination of spermatozoa obtained by midodrin-induced retrograde ejaculation

Cited by 2 publications

References 18 publications

The alpha-sympathomimetic midodrin as a tool for diagnosis and treatment of sperm transport disturbances

The alpha-sympathomimetic midodrin as a tool for diagnosis and treatment of sperm transport disturbances

Grossesse apres Fecondation In Vitro dans un cas d’ejaculation seche (absence d’emission) partiellement ameliore par traitement pharmacologique

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