EMILIN2 Correlated With Its Methylation and Immune Infiltration Could Be an Independent Prognostic Biomarker in LGG

Abstract

Low-grade gliomas (LGGs) are slow-growing brain cancer in central nervous system neoplasms. EMILIN2 is an extracellular matrix (ECM) protein which could influence the progress of some tumour which is unclear in LGG. In our study, the methylation, expression, prognosis and immune value of EMILIN2 were analysed in LGG through bioinformatics analysis. we first analysed the LGG data from TCGA and discovered that the EMILIN2 expression, negatively correlated to the EMILIN2 methylation could predict a poor prognosis and associated with different clinical parameters. Moreover, univariate and multivariate Cox regression were performed in CGGA showed that the EMILIN2 could be an independent prognostic biomarker in LGG. Finally, EMILIN2 expression showed a correlation with gene makers in some immune cells which identified the significance of EMILIN2 in immune infiltration. In conclusion, EMILIN2 could act as an independent prognostic biomarker which might be associated with the malignancy and development of gliomas and play a crucial role in glioma in immune infiltration.