Emigration to western industrialized countries: A risk factor for developing inflammatory bowel disease

Acosta, Manuel Barreiro‐de; Castro, Ana; Souto, Raquel; Iglesias, Marta; Lorenzo, Aurelio; Domínguez–Muñoz, J. Enrique

doi:10.1016/j.crohns.2011.05.009

Cited by 72 publications

(56 citation statements)

References 15 publications

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“…The rapid pace of these epidemiological changes is too brisk for them to result from changes in gene frequency, pointing to an environmental effect on the risk of disease. Studies of emigrant groups support this hypothesis [7]. Studies of migrant populations suggest early childhood environmental influence is crucial; children take on the risk profile of their new environment, whereas their parents maintain the risk profile of their country of origin [11].…”

Section: The Gut Microbiota: the Proximate Environmental Risk Factor mentioning

confidence: 57%

“…The increasing prevalence of IBD worldwide also supports the primacy of environmental risk factors [7,8] in the development of IBD, except in rare cases of monogenic disease [9]. The most consistent epidemiological feature of both UC and CD is the increase in incidence and prevalence when a society transitions from developing to developed [10].…”

Section: The Gut Microbiota: the Proximate Environmental Risk Factor mentioning

confidence: 96%

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The microbiota in inflammatory bowel disease

2015

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This review explores our current understanding of the complex interaction between environmental risk factors, genetic traits and the development of inflammatory bowel disease. The primacy of environmental risk factors is illustrated by the rapid increase in the incidence of the disease worldwide. We discuss how the gut microbiota is the proximate environmental risk factor for subsequent development of inflammatory bowel disease. The evolving fields of virome and mycobiome studies will further our understanding of the full potential of the gut microbiota in disease pathogenesis. Manipulating the gut microbiota is a promising therapeutic avenue.

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Section: The Gut Microbiota: the Proximate Environmental Risk Factor mentioning

confidence: 57%

Section: The Gut Microbiota: the Proximate Environmental Risk Factor mentioning

confidence: 96%

The microbiota in inflammatory bowel disease

2015

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“…Such work was done on the occurrence of cancer in migrants in the 1990s in Uruguay (48) , Brazil (9) and Argentina (30) . An interesting recent Spanish study on emigration looked at 34 patients who had emigrated to other parts of Europe and 16 to South America (6) . The authors suggested that emigration was associated with ulcerative colitis and not with Crohn's disease.…”

Section: Incidence and Prevalence In Central And South Americamentioning

confidence: 99%

INFLAMMATORY BOWEL DISEASE IN HISPANIC COMMUNITIES: a concerted South American approach could identify the aetiology of Crohn’s disease and ulcerative colitis

Farrukh

Mayberry

2014

Arq. Gastroenterol.

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-Despite intensive research we remain ignorant of the cause of both Crohn's disease and ulcerative colitis. The dramatic rise in incidence, particularly of Crohn's disease, points towards environmental factors as playing a significant role. A major purpose of this review is to stimulate a co-ordinated international effort to establish an on-going data base in Central and South America in which new cases are registered and through which investigations into aetiology can be conducted. In both Brazil and Mexico

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“…Air pollution and in particular burning fossil-fuels related pollutants which contains a large amount of nitrogen oxides and levitate particles have been problematic in recent decades especially in urban and industrial communities as a public health hazard [10,[15][16][17][18][19]. In fact the risk factors of industrialization were not fully evaluated and in this retrospective study, we have evaluated any potential effect of air pollution as a trigger factor on the rate and duration of hospital admission due to hepatic encephalopathy among a referral center in a capital industrial city of Khuzestan province.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Relation Between Air Pollution and Hepatic Encephalopathy Exacerbation

Alavinejad¹,

Mard²,

Esk³

et al. 2016

GHOA

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In this retrospective cross sectional survey, by evaluating the records of Ahvaz aerology stations and air pollution committee of Ahvaz Jundishapur University, the DATA about 4 major air AbstractBackground: To evaluate relation between air pollution and rate and duration of hospital admission due to hepatic encephalopathy as a major complication of liver cirrhosis. Methods:In this retrospective study, during a 10 months period, the number and average duration of hospitalization of patients admitted in GI ward of a referral center due to hepatic encephalopathy were recorded in an industrial capital city. Concomitantly the level of 4 major air pollutants including SO 2 , CO, NO 2 and O 3 measured and the correlation between severity of hepatic encephalopathy and air pollution determined by Pearson correlation coefficient.Results: Average number of admission was 5 to 6 patients per month (1-10). The average duration of hospitalization was 7.6 days (3-19). After comparison of average concentration of 4 major air pollutants with rate of hepatic encephalopathy, there was a relation, between O3 concentration and duration of admissions (P=0.048, correlation coefficient 0.636) and also a non-significant relation between O3 concentration and number of admissions (P=0.78, correlation coefficient 0.58). DATA analysis did not reveal any significant relation between SO 2 , NO 2 and CO and the rate and duration of admission due to hepatic encephalopathy (P > 0.05). Conclusion:It seems that O 3 as one of the major air pollutants can aggravates course of hepatic encephalopathy. This issue should further be clarified in future studies.

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Emigration to western industrialized countries: A risk factor for developing inflammatory bowel disease

Abstract: People who emigrate to westernised countries have a higher risk for developing IBD, especially UC. Environmental factors related with industrialization seem to play an important role in the pathogenesis of these diseases.

Cited by 72 publications

References 15 publications

The microbiota in inflammatory bowel disease

The microbiota in inflammatory bowel disease

INFLAMMATORY BOWEL DISEASE IN HISPANIC COMMUNITIES: a concerted South American approach could identify the aetiology of Crohn’s disease and ulcerative colitis

Evaluation of Relation Between Air Pollution and Hepatic Encephalopathy Exacerbation

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