Emervaridione and varioxiranediol, two new metabolites from the endophytic fungus, Emericella variecolor

Liangsakul, Jatupol; Pornpakakul, Surachai; Sangvichien, Ek; Muangsin, Nongnuj; Sihanonth, Prakitsin

doi:10.1016/j.tetlet.2011.09.079

Cited by 21 publications

(27 citation statements)

References 27 publications

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“…Aer the isolation of the rst member of this group in 1976, 47 >100 compounds have been described as DMOA-derived meroterpenoids. These molecules include andrastin A (71), [48][49][50] austinol (72), 51 terretonin (73), 52 anditomin (74), 53 novofumigatonin (75), 54 tropolactone A (76), 55 paraherquonin (77), 56 and emervaridione (78) 57 (Fig. 7).…”

Section: Meroterpenoids Derived From 35demethylorsellinic Acidmentioning

confidence: 99%

Biosynthesis of fungal meroterpenoids

2016

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Covering: up to September 2015. Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite diverse structures, with a wide range of biological properties. This review summarizes the molecular bases for their biosyntheses, which were recently elucidated with modern techniques, and also discusses the plausible biosynthetic pathways of other related natural products lacking genetic information. (Complementary to the coverage of literature by Geris and Simpson in Nat. Prod. Rep., 2009, 26, 1063-1094.).

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Section: Meroterpenoids Derived From 35demethylorsellinic Acidmentioning

confidence: 99%

Biosynthesis of fungal meroterpenoids

2016

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“…These compounds are meroterpenoids and isolated from the Aspergillus and Penicillium genera. These derivatives have noteworthy levels of toxicities against insects and also block the nicotinic acetylcholine of cockroaches [70].…”

Section: Meroterpenesmentioning

confidence: 99%

“…Emervaridione (105) and varioxiranediol (106) were published from E. variecolor ( Figure 6) [70]. Investigation of an E. variecolor-derived sponge (Cinachyrella sp.)…”

Section: Meroterpenesmentioning

confidence: 99%

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Nidulantes of Aspergillus (Formerly Emericella): A Treasure Trove of Chemical Diversity and Biological Activities

et al. 2020

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The genus Emericella (Ascomycota) includes more than thirty species with worldwide distribution across many ecosystems. It is considered a rich source of diverse metabolites. The published classes of natural compounds that are discussed here are organized according to the following biosynthetic pathways: polyketides (azaphilones, cyclopentenone pigments, dicyanides, furan derivatives, phenolic ethers, and xanthones and anthraquinones); shikimate derivatives (bicoumarins); mevalonate derivatives (meroterpenes, sesquiterpenes, sesterterpenes and steroids) and amino acids derivatives (alkaloids (indole-derivatives, isoindolones, and piperazine) and peptides (depsipeptides)). These metabolites produce the wide array of biological effects associated with Emericella, including antioxidant, antiproliferative, antimalarial, antiviral, antibacterial, antioxidant, antihypertensive, anti-inflammatory, antifungal and kinase inhibitors. Careful and extensive study of the diversity and distribution of metabolites produced by the genus Emericella (either marine or terrestrial) revealed that, no matter the source of the fungus, the composition of the culture medium effectively controls the metabolites produced. The topic of this review is the diversity of metabolites that have been identified from Emericella, along with the contextual information on either their biological or geographic sources. This review presents 236 natural compounds, which were reported from marine and terrestrial Emericella. Amongst the reported compounds, only 70.2% were biologically assayed for their effects, including antimicrobial or cytotoxicity. This implies the need for substantial investigation of alternative activities. This review includes a full discussion of compound structures and disease management, based on materials published from 1982 through December 2019.

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“…60 Six drimane sesquiterpenoid ethers of isocitric acid named cryptoporic acids J-O 68-73, which possess inhibitory effects on nitric oxide production, have been obtained from the fruiting bodies of Cryptoporus sinensis, 61,62 whilst fudecadione A 74 and fudecadione B 75 have been isolated from a soil fungus of the Penicillium genus. 65 Another organism of this type, Phomopsis archeri, 66 contains the sesquiterpenoids phomoarcherins A-C 83-85, while isocochlioquinone B 86 was isolated from cultures of a Cochliobolus sp., an endophytic fungus of Phragmites australis. 64 The structure of emervaridione has been determined as 82.…”

Section: Bicyclofarnesanementioning

confidence: 99%