Emerindanols A and B: Two Bipolyhydroindenol Sesterterpenes with 5/6–6/5 Coupled Ring System Discovered by Genome Mining
Shuzhi Liu,
Wenjing Wang,
Qingpei Liu
et al.
Abstract:Genome mining of Emericella sp. XL-029 achieved a new type E sesterterpene synthase, EmES, which affored a novel bipolyhydroindenol sesterterpene, emerindanol A. Heterologous coexpression with the upstream P450 oxidase revealed C-4 hydroxylated product, emerindanol B. Notably, emerindanols A and B represented the first sesterterpenes featuring a unique 5/6−6/ 5 coupled ring system. EmES was postulated to initiate through C1−IV−V pathway and convert the fused ring intermediate into the final coupled ring produc… Show more
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as nitidane from Heteromurus nitidus.
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as nitidane from Heteromurus nitidus.
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