Emerging various environmental threats to brain and overview of surveillance system with zebrafish model

Vargas, Rafael; Ponce-Canchihuamán, Johny

doi:10.1016/j.toxrep.2017.08.002

Cited by 22 publications

(11 citation statements)

References 59 publications

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“…), 2.5 mg/kg ( p.o .) [[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]] and at pre-clinical dose of 3 mg/kg (p.o. ), 6-8 mg/kg (p.o), 0.3 mg/kg, (i.p.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective potential of solanesol in intracerebroventricular propionic acid induced experimental model of autism: Insights from behavioral and biochemical evidence

2019

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Autism is the category used within the newest edition of the diagnostic and statistical manual of neurodevelopmental disorders. Autism is a spectrum of disorder where a variety of behavioural patterns observed in autistic patients, such as stereotypes and repetitive behavior, hyperexcitability, depression-like symptoms, and memory and cognitive dysfunctions. Neuropathological hallmarks that associated with autism are mitochondrial dysfunction, oxidative stress, neuroinflammation, Neuro-excitation, abnormal synapse formation, overexpression of glial cells in specific brain regions like cerebellum, cerebral cortex, amygdala, and hippocampus. ICV injection of propionic acid (PPA) (4 μl/0.26 M) mimics autistic-like behavioral and biochemical alterations in rats. Literature findings reveal that there is a link between autism neuronal mitochondrial coenzyme-Q10 (CoQ10) and ETC-complexes dysfunctions are the keys pathogenic events for autism. Therefore, in the current study, we explore the neuroprotective interventions of Solanesol (SNL) 40 and 60 mg/kg alone and in combination with standard drugs Aripiprazole (ARP) 5 mg/kg, Citalopram (CTP) 10 mg/kg, Memantine (MEM) 5 mg/kg and Donepezil (DNP) 3 mg/kg to overcome behavioral and biochemical alterations in PPA induced experimental model of Autism. Chronic treatment with SNL 60 mg/kg in combination with standard drug shows a marked improvement in locomotion, muscle coordination, long-term memory and the decrease in depressive behavior. While, chronic treatment of SNL alone and in combination with standard drug aripiprazole, citalopram, donepezil, and memantine shows the Neuroprotective potential by enhancing the cognitive deficits, biochemical alterations along with reducing the level of inflammatory mediators and oxidative stress.

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“…), 2.5 mg/kg ( p.o .) [[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]] and at pre-clinical dose of 3 mg/kg (p.o. ), 6-8 mg/kg (p.o), 0.3 mg/kg, (i.p.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective potential of solanesol in intracerebroventricular propionic acid induced experimental model of autism: Insights from behavioral and biochemical evidence

2019

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“…Sumithion is considered somewhat toxic to fish [7]. The pesticide affects the aquatic ecosystem by interrupting the aquatic food chain resulting in the loss/shift in abundance of natural invertebrate and vertebrate species in the aquatic environment [8,9]. It has been reported that several organophosphate pesticides, such as malathion altered histopathology and molecular disorder of liver and kidney in mice [10], triazophos and deltamethrin inhibited AChE activity in Channa punctatus [11] and imidacloprid caused the histopathological changes, activation of TNF-α, iNOS, 8-OHdG biomarkers, and alteration of caspase3, iNOS, CYP1A, MT1 gene expression levels in common carp [12].…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity of an organophosphate insecticide sumithion to striped catfish Pangasianodon hypophthalmus

et al. 2019

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“…Since CO affinity to hemoglobin is approximately 230–270-fold higher than that of O 2 to hemoglobin, even at low CO concentrations, the carboxyhemoglobin concentration becomes sufficiently high to induce toxicity (9). The clinical manifestations of CO poisoning are non-specific (i.e., headaches, fatigue, confusion, nausea, dizziness, visual problems, chest pain, shortness of breath, loss of consciousness and seizures) and they are principally associated with the deleterious effects of normobaric on the brain and heart (11,12).…”

Section: Introductionmentioning

confidence: 99%

Magnesium sulfate ameliorates carbon monoxide‑induced cerebral injury in male rats

et al. 2018

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Carbon monoxide (CO) has been shown to induce several cardiovascular abnormalities, as well as necrosis, apoptosis and oxidative stress in the brain. Magnesium sulfate (MS) has been shown to have beneficial activities against hypoxia in the brain. In the present study, the possible protective effects of MS against CO-induced cerebral ischemia were investigated. For this purpose, 25 male Wistar rats were exposed to 3,000 ppm CO for 1 h. The animals were divided into 5 groups (n=5 in each group) as follows: The negative control group (not exposed to CO), the positive control group (CO exposed and treated with normal saline), and 3 groups of CO-exposed rats treated with MS (75, 150 and 300 mg/kg/day) administered intraperitoneally for 5 consecutive days. On the 5th day, the animals were sacrificed and the brains were harvested for the evaluation of necrosis, apoptosis and oxidative stress. Histopathological evaluation revealed that MS reduced the number and intensity of necrotic insults. The Bax/Bcl2 ratio and malondialdehyde (MDA) levels were significantly decreased in a dose-dependent manner in the MS-treated rats compared to the positive control group, while a significant dose-dependent increase in Akt expression, a pro-survival protein, was observed. In addition, MS administration reduced pro-apoptotic indice levels, ameliorated histological insults, favorably modulated oxidative status and increased Akt expression levels, indicating a possible neuroprotective effect in the case of CO poisoning. On the whole, the findings of this study indicate that MS may prove to be useful in protecting against CO-induced cerebral injury.

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Emerging various environmental threats to brain and overview of surveillance system with zebrafish model

Abstract: Graphical abstract

Cited by 22 publications

References 59 publications

Neuroprotective potential of solanesol in intracerebroventricular propionic acid induced experimental model of autism: Insights from behavioral and biochemical evidence

Neuroprotective potential of solanesol in intracerebroventricular propionic acid induced experimental model of autism: Insights from behavioral and biochemical evidence

Acute toxicity of an organophosphate insecticide sumithion to striped catfish Pangasianodon hypophthalmus

Magnesium sulfate ameliorates carbon monoxide‑induced cerebral injury in male rats

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