Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge to Conventional Coagulation Tests? Part I: The Use of Thromboelastography and Thromboelastometry in the Assessment of Hemostatic Function

Kwaan, Hau C.; Walsh, Mark; Lindholm, Paul F.; Othman, Maha

doi:10.1055/s-0042-1756700

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…Viscoelastic tests, which are performed on a whole blood sample and offer a holistic view of ex vivo coagulation, provide results within minutes and can therefore be viewed and evaluated at the point-of-care. 53 The most established of these tests are thromboelastography (TEG 5000) and rotational thromboelastometry (ROTEM delta). 53 In TEG, whole blood and clotting activators are mixed in a disposable cup heated to 37 °C and subjected to slow periodic and alternating rotations.…”

Section: Global Assays In Mbds and Bducmentioning

confidence: 99%

“…53 The most established of these tests are thromboelastography (TEG 5000) and rotational thromboelastometry (ROTEM delta). 53 In TEG, whole blood and clotting activators are mixed in a disposable cup heated to 37 °C and subjected to slow periodic and alternating rotations. A disposable plastic pin, suspended in the center of the cup, is enveloped by the developing clot.…”

Section: Global Assays In Mbds and Bducmentioning

confidence: 99%

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Utility of Global Hemostatic Assays in Patients with Bleeding Disorders of Unknown Cause

Mehic,

Assinger,

Gebhart

2024

Hamostaseologie

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Bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion after exhaustive evaluation of plasmatic coagulation and platelet function. This review explores the utility of global hemostatic assays as confirmatory tests and in elucidating the pathophysiology of BDUC. Unlike traditional hemostatic tests that focus on coagulation factors, global assays are conducted both in plasma and also whole blood. These assays provide a more comprehensive understanding of the cell-based model of coagulation, aid in the identification of plasmatic factor abnormalities that may reduce hemostatic capacity, and allow for the assessment of impaired platelet–endothelial interactions under shear stress, as well as hyperfibrinolytic states. While clinical tests such as skin bleeding time and global assays such as PFA-100 exhibit limited diagnostic capacity, the role of viscoelastic testing in identifying hemostatic dysfunction in patients with BDUC remains unclear. Thrombin generation assays have shown variable results in BDUC patients; some studies demonstrate differences compared with healthy controls or reference values, whereas others question its clinical utility. Fibrinolysis assessment in vitro remains challenging, with studies employing euglobulin clot lysis time, plasma clot lysis time, and fluorogenic plasmin generation yielding inconclusive or conflicting results. Notably, recent studies suggest that microfluidic analysis unveils shear-dependent platelet function defects in BDUC patients, undetected by conventional platelet function assays. Overall, global assays might be helpful for exploring underlying hemostatic impairments, when conventional hemostatic laboratory tests yield no results. However, due to limited data and/or discrepant results, further research is needed to evaluate the utility of global assays as screening tools.

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Section: Global Assays In Mbds and Bducmentioning

confidence: 99%

Section: Global Assays In Mbds and Bducmentioning

confidence: 99%

Utility of Global Hemostatic Assays in Patients with Bleeding Disorders of Unknown Cause

Mehic,

Assinger,

Gebhart

2024

Hamostaseologie

View full text Add to dashboard Cite

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“…Several past issues of the journal are also worthy of highlighting as most contributing to the 2023 IF. Seven issues of STH managed to achieve a total citation count of more than 30 citations per issue 8 9 46 47 48 49 50 :…”

Section: Most Highly Cited Papers Contributing To the 2023 Sth Impact...mentioning

confidence: 99%

“…Part I: The Use of Thromboelastography and Thromboelastometry in the Assessment of Hemostatic Function. 50 Guest Editors: Hau C. Kwaan, Mark Walsh, Paul F. Lindholm, and Maha Othman. Published in late 2022, and marking the first of two issues on viscoelastography, this issue includes the most highly cited paper in Table 1 .…”

Section: Most Highly Cited Papers Contributing To the 2023 Sth Impact...mentioning

confidence: 99%

New STH 2023 Impact Factor, Most Highly Cited Papers, and Other Journal Metrics

Favaloro

2024

Semin Thromb Hemost

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Standardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH

Baker,

Choi,

Curry

et al. 2024

Journal of Thrombosis and Haemostasis

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Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge to Conventional Coagulation Tests? Part I: The Use of Thromboelastography and Thromboelastometry in the Assessment of Hemostatic Function

Cited by 4 publications

References 13 publications

Utility of Global Hemostatic Assays in Patients with Bleeding Disorders of Unknown Cause

Utility of Global Hemostatic Assays in Patients with Bleeding Disorders of Unknown Cause

New STH 2023 Impact Factor, Most Highly Cited Papers, and Other Journal Metrics

Standardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH

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