Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy

Khan, Fahad; Pandey, Pratibha; Verma, Meenakshi; Ramniwas, Seema; Lee, Dain; Moon, Seungjoon; Park, Moon Nyeo; Upadhyay, Tarun Kumar; Kim, Bonglee

doi:10.1016/j.biopha.2024.116363

Cited by 4 publications

(1 citation statement)

References 172 publications

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“…Ferroptosis is characterized by the existence of diminished mitochondria and decreased mitochondrial cristae [ 23 ]. This mechanistic characteristic sets ferroptosis apart from other modes of RCD, which are governed by specific proteins that execute cell death [ 24 ]. Dysregulated actions in the molecular network that regulate ferroptosis have been recognized as significant contributors to the advancement of various diseases, including HCC [ 25 – 27 ].…”

Section: Introductionmentioning

confidence: 99%

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

Jin,

Huang,

Tian

2024

Clin Exp Med

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Despite being characterized by high malignancy, high morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form of regulated cell death, possesses distinct morphological, biochemical, and genetic characteristics compared to other types of cell death. Dysregulated actions within the molecular network that regulates ferroptosis have been identified as significant contributors to the progression of HCC. Long non-coding RNAs (lncRNAs) have emerged as influential contributors to diverse cellular processes, regulating gene function and expression through multiple mechanistic pathways. An increasing body of evidence indicates that deregulated lncRNAs are implicated in regulating malignant events such as cell proliferation, growth, invasion, and metabolism by influencing ferroptosis in HCC. Therefore, elucidating the inherent role of ferroptosis and the modulatory functions of lncRNAs on ferroptosis in HCC might promote the development of novel therapeutic interventions for this disease. This review provides a succinct overview of the roles of ferroptosis and ferroptosis-related lncRNAs in HCC progression and treatment, aiming to drive the development of promising therapeutic targets and biomarkers for HCC patients.

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Section: Introductionmentioning

confidence: 99%

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

Jin,

Huang,

Tian

2024

Clin Exp Med

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FTX promotes esophageal cancer progression and desensitizes esophageal cancer cells to ionizing radiation by microRNA-99a/b-3p/WEE1/ERCC1 axis

Xu,

Huang,

Mao

et al. 2024

Oncologie

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Objectives This study was conducted to uncover the underlying cellular and molecular mechanisms of FTX dysregulation in EC. Methods The gene expression in tumor tissues was detected using western blot, immunohistochemistry, and quantitative real-time polymerase chain reaction (qPCR). The dual-luciferase reporter and RNA FISH assays confirmed the interaction between miRNA and target genes. Mouse models for Xenograft and lung metastasis were used to assess EC cell tumorigenesis and metastasis. Results This study finds that up-regulated FTX in patients with esophageal cancer correlates with poor clinical outcomes. Silencing FTX inhibits esophageal cancer cell growth and migration in vitro and tumor metastasis in vivo. miR-99a/b-3p sensitizes esophageal cancer cells to ionizing radiation by WEE1 (Wee1-like protein kinase) and ERCC1 (excision repair cross-complementation group 1) in vitro. Conclusions FTX promotes the malignant biological phenotype of esophageal cancer cells. Mechanistically, FTX acts as a ceRNA to regulate the transcription of WEE1 and ERCC1 by sponging hsa-miR-99a/b-3p.

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Identification of Ferroptosis-Inducers Targeting Glutathione Peroxidase 4 from Herbal Compounds Using Comprehensive Computational Approaches

Tabar,

Ghasemian,

Kouhpayeh

et al. 2024

Preprint

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Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy

Cited by 4 publications

References 172 publications

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

FTX promotes esophageal cancer progression and desensitizes esophageal cancer cells to ionizing radiation by microRNA-99a/b-3p/WEE1/ERCC1 axis

Identification of Ferroptosis-Inducers Targeting Glutathione Peroxidase 4 from Herbal Compounds Using Comprehensive Computational Approaches

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