Emerging trends of long non‐coding <scp>RNA</scp>s in gene activation

Krishnan, Jaya; Mishra, Rakesh K.

doi:10.1111/febs.12578

Cited by 37 publications

(29 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently, evidence has accumulated indicating that long non-coding RNAs contribute to structural or chemical modifications of chromatin and gene activation besides the well-known repression of gene expression [40]. The non-coding RNA, prt6 , could exert regulatory roles in gene expression in its full length and/or its putative non-coding variants, as shown in Figure 2A .…”

Section: Discussionmentioning

confidence: 99%

Identification of Developmentally Regulated PCP-Responsive Non-Coding RNA, prt6, in the Rat Thalamus

et al. 2014

View full text Add to dashboard Cite

Schizophrenia and similar psychoses induced by NMDA-type glutamate receptor antagonists, such as phencyclidine (PCP) and ketamine, usually develop after adolescence. Moreover, adult-type behavioral disturbance following NMDA receptor antagonist application in rodents is observed after a critical period at around 3 postnatal weeks. These observations suggest that the schizophrenic symptoms caused by and psychotomimetic effects of NMDA antagonists require the maturation of certain brain neuron circuits and molecular networks, which differentially respond to NMDA receptor antagonists across adolescence and the critical period. From this viewpoint, we have identified a novel developmentally regulated phencyclidine-responsive transcript from the rat thalamus, designated as prt6, as a candidate molecule involved in the above schizophrenia-related systems using a DNA microarray technique. The transcript is a non-coding RNA that includes sequences of at least two microRNAs, miR132 and miR212, and is expressed strongly in the brain and testis, with trace or non-detectable levels in the spleen, heart, liver, kidney, lung and skeletal muscle, as revealed by Northern blot analysis. The systemic administration of PCP (7.5 mg/kg, subcutaneously (s.c.)) significantly elevated the expression of prt6 mRNA in the thalamus at postnatal days (PD) 32 and 50, but not at PD 8, 13, 20, or 24 as compared to saline-treated controls. At PD 50, another NMDA receptor antagonist, dizocilpine (0.5 mg/kg, s.c.), and a schizophrenomimetic dopamine agonist, methamphetamine (4.8 mg/kg, s.c.), mimicked a significant increase in the levels of thalamic prt6 mRNAs, while a D2 dopmamine receptor antagonist, haloperidol, partly inhibited the increasing influence of PCP on thalamic prt6 expression without its own effects. These data indicate that prt6 may be involved in the pathophysiology of the onset of drug-induced schizophrenia-like symptoms and schizophrenia through the possible dysregulation of target genes of the long non-coding RNA or microRNAs in the transcript.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of Developmentally Regulated PCP-Responsive Non-Coding RNA, prt6, in the Rat Thalamus

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Comparing to microRNA, lncRNAs are over 200 nt noncoding RNAs, which are emerging as new players in gene regulation as posttranscriptional regulators of splicing or as molecular decoys for microRNA [88]. Besides, some other mechanisms have been proposed to explain its mediated gene expression by lncRNA [89]. Although many lncRNAs have been identified, of all lncRNAs only few have been well characterized.…”

Section: Current and Emerging Biomarkers Of Cell Deathmentioning

confidence: 99%

Current and Emerging Biomarkers of Cell Death in Human Disease

Chen

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Cell death is a critical biological process, serving many important functions within multicellular organisms. Aberrations in cell death can contribute to the pathology of human diseases. Significant progress made in the research area enormously speeds up our understanding of the biochemical and molecular mechanisms of cell death. According to the distinct morphological and biochemical characteristics, cell death can be triggered by extrinsic or intrinsic apoptosis, regulated necrosis, autophagic cell death, and mitotic catastrophe. Nevertheless, the realization that all of these efforts seek to pursue an effective treatment and cure for the disease has spurred a significant interest in the development of promising biomarkers of cell death to early diagnose disease and accurately predict disease progression and outcome. In this review, we summarize recent knowledge about cell death, survey current and emerging biomarkers of cell death, and discuss the relationship with human diseases.

show abstract

“…Moreover, the lncRNA CCAT1-L also plays a role in MYC transcriptional regulation, and CCAT1-L overexpression promoted MYC transcription and enhanced tumorigenesis [16]. These findings suggest that lncRNAs may serve as important regulators of TFs in tumorigenesis and thus comprise a new RNA-based gene regulation mechanism that complements the central dogma [17]. Therefore, studying lncRNA-mediated changes in TF activity is an important step in determining lncRNA functions at a system-wide level.…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of lncRNA mediated transcriptional dysregulation dictates lncRNA roles in glioblastoma

Wang

et al. 2016

Oncotarget

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) modulate gene expression, and lncRNA misregulation is associated with cancer. However, precise functional roles in biological and disease processes have been described for only a few lncRNAs. Identification of genome-wide lncRNA-mediated transcriptional dysregulations may improve cancer treatments. In the present study, we used a computational framework that combined lncRNA and gene expression profiles with transcription factor (TF)-target relationships to comprehensively identify dysregulatory lncRNA-TF-gene triplets. In glioblastoma (GBM), we found that most lncRNAs affect multiple targets and primarily affect TF activity in trans. Six different classes of lncRNA-mediated transcriptional dysregulations were identified, with most lncRNAs either enhancing or attenuating target gene expression. Functional analysis of lncRNAs via their dysregulated targets implicated lncRNA modulators in some hallmarks of cancer, providing a new way to predict lncRNA function. Finally, we identified several lncRNA-TF-gene triplets (including HOTAIR-MXI1-CD58/PRKCE and HOTAIR-ATF5-NCAM1) that are associated with glioblastoma prognosis. The integration of lncRNA modulators into transcriptional regulatory networks will further enhance our understanding of lncRNA functions in cancer.

show abstract

Emerging trends of long non‐coding RNAs in gene activation

Cited by 37 publications

References 94 publications

Identification of Developmentally Regulated PCP-Responsive Non-Coding RNA, prt6, in the Rat Thalamus

Identification of Developmentally Regulated PCP-Responsive Non-Coding RNA, prt6, in the Rat Thalamus

Current and Emerging Biomarkers of Cell Death in Human Disease

Identification and characterization of lncRNA mediated transcriptional dysregulation dictates lncRNA roles in glioblastoma

Contact Info

Product

Resources

About