Emerging Trends in the Use of Therapeutic Hypothermia as a Method for Neuroprotection in Brain Damage (Review)

Ш, Усманов Э; Chubarova, M. A.; Саидов, Ш Х

doi:10.17691/stm2020.12.5.11

Cited by 3 publications

(8 citation statements)

References 123 publications

(122 reference statements)

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“…Most specialists have no doubts about its effectiveness in cardiopulmonary resuscitation and for newborns with hypoxic–ischaemic encephalopathy. The use of therapeutic hypothermia techniques in ischaemic stroke seems justified, but there are still many questions about the effectiveness and disputes continue 30 …”

Section: Discussion/conclusionmentioning

confidence: 99%

“…Most of the data devoted to mild hypothermia's effectiveness for stroke treatment is limited to animal studies. Experiments on mice and rats noted its neuroprotective effect 30–32 . However, its mechanisms are still not sufficiently understood.…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…33 Supposedly, a decrease in the temperature of a neuron by 1°C reduces its metabolic needs from 5%-6% to 10%, and when the temperature reaches 33°C, the metabolic level decreases by 25%-40%. 30 Other animal experiments have shown that hypothermia decreases cerebral perfusion, but its metabolism considerably decelerates, thus restoring equilibrium. The data were validated using the parameters obtained from positron emission tomography.…”

Section: The Expression Of Grp78 P-perk P-eif2α Atf4 and Chopmentioning

confidence: 99%

“…The use of therapeutic hypothermia techniques in ischaemic stroke seems justified, but there are still many questions about the effectiveness and disputes continue. 30 Most of the data devoted to mild hypothermia's effectiveness for stroke treatment is limited to animal studies. Experiments on mice and rats noted its neuroprotective effect.…”

Section: The Expression Of Grp78 P-perk P-eif2α Atf4 and Chopmentioning

confidence: 99%

“…Experiments on mice and rats noted its neuroprotective effect. [30][31][32] However, its mechanisms are still not sufficiently understood. This study focused on the neuroprotective mechanism of mild hypothermia.…”

Section: The Expression Of Grp78 P-perk P-eif2α Atf4 and Chopmentioning

confidence: 99%

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Role of PERK‐mediated pathway in the effect of mild hypothermia after cerebral ischaemia/reperfusion

Zhao

Xia

Tang

et al. 2023

Eur J Clin Investigation

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BackgroundHypothermia is an effective method of reducing brain injury caused by a variety of neurological insults. It is aimed to elucidate whether a change in the expression of PERK‐mediated pathway proteins is an indicator of the neuroprotective effect of mild hypothermia after cerebral ischaemia/reperfusion.MethodsOne hundred and ninety‐two male C57BL/6 mice were randomly divided into three groups: a sham group, a cerebral normothermic ischaemia/reperfusion (I/R) group and a cerebral hypothermic I/R group. A cerebral ischaemia model was established by ligating the bilateral common carotid artery for 15 min. Mice in the hypothermia group stayed in a cage that was set at 33°C, sprayed with a spray of 70% ethanol, and blown with two high‐speed fans. The state of neurons was assessed on micropreparations stained with haematoxylin–eosin and TUNEL. The expressions of GRP78, p‐perk, p‐eif2α, ATF4 and CHOP were measured by western blot analysis 6, 12, 24 and 72 h after reperfusion.ResultsThe number of surviving cells was significantly higher in the hypothermia group than in the group without hypothermia (p < .05). The GRP78 expression in the hypothermia group was statistically higher (p < .05) than in the ischaemia/reperfusion group. Optical densities of p‐perk, p‐eif2α and ATF4 in hippocampus CA1 neurons ischaemia were statistically significantly lower in the hypothermia group than in the ischaemia/reperfusion group (p < .05). The CHOP expression in the hypothermia group was statistically lower (p < .05) than in the ischaemia/reperfusion group.ConclusionMild hypothermia for 6 h promoted moderate neuroprotection by mediating the expression of GRP78, p‐PERK, p‐eIF2α, ATF4 and CHOP.

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Section: Discussion/conclusionmentioning

confidence: 99%

Section: Discussion/conclusionmentioning

confidence: 99%

Section: The Expression Of Grp78 P-perk P-eif2α Atf4 and Chopmentioning

confidence: 99%

Section: The Expression Of Grp78 P-perk P-eif2α Atf4 and Chopmentioning

confidence: 99%

Section: The Expression Of Grp78 P-perk P-eif2α Atf4 and Chopmentioning

confidence: 99%

See 3 more Smart Citations

Role of PERK‐mediated pathway in the effect of mild hypothermia after cerebral ischaemia/reperfusion

Zhao

Xia

Tang

et al. 2023

Eur J Clin Investigation

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Impact of therapeutic hypothermia (whole body cooling) on severely asphyxiated term neonates: a prospective non-randomized comparative study in an Indian tertiary care setting

Shah,

Aiyer,

Singh

2024

Int J Contemp Pediatr

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Background: Early application of Therapeutic Hypothermia within 6 hours of birth is neuroprotective. We aimed at examining whether therapeutic hypothermia alongside standard optimal intensive care improves immediate survival outcome and reduces neuro-disability. Methods: This was a prospective non-randomized study involving inborn and out born newborns admitted at NICU, carried out from March 2022 to December 2022. Eligible candidates were enrolled as cases and therapeutic hypothermia was offered while rest were included as a control group and monitored likewise for the overall survival and neurological outcome. These babies were followed up till 1 month and 3 months of age to assess neurological outcome. Results: In this study, a total of 47 patients were enrolled both from extramural and intramural NICU set ups. Of them, 22 patients were offered Therapeutic Hypothermia and 25 patients were given standard post asphyxia care. 7 out of 9 inborn patients and 3 out of 13 out born neonates who were offered therapeutic hypothermia survived whereas 5 out of 11 inborn and 4 out of 14 out born neonates who were offered standard post asphyxia care survived. Conclusions: Therapeutic hypothermia cannot be attributed to significant increase or decrease in mortality when compared with standard care group. No inference could be made about hypothermic neuroprotection in the follow up study. Overall survival outcome was better in inborn patients than that of outborn. Inborn neonates subjected to therapeutic hypothermia, showed a trend towards better survival than those given standard post asphyxia care.

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Advanced Diagnostic Tools in Hypothermia-Related Fatalities—A Pathological Perspective

Hleșcu,

Grigoraș,

Ianole

et al. 2024

Diagnostics

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Background and Objectives: Although classical gross features are known in hypothermia victims, they lack specific diagnosis features. The aim of our study was to reveal specific brain and lung pathological features in a group of hypothermia-related fatalities. Materials and Methods: The study group comprised 107 cases from our files associated with hypothermia. Routine hematoxylin–eosin (H&E) staining and postmortem immunohistochemistry were performed. Results: The microscopic cerebral exam revealed diffuse perineuronal and perivascular edema, gliosis, mononuclear cell infiltration, acute brain injuries, focal neuronal ischemia, lacunar infarction, and variable hemorrhages. Variable alveolar edema, pulmonary emphysema, intra-alveolar and/or pleural hemorrhage, and bronchopneumonia, as well as other pre-existing lesions, were identified in lung tissue samples. Glial cells displayed S100β expression, while neurons showed moderate Hsp70 immunopositivity. Alveolar basal membranes exhibited diffuse ICAM-1 positive expression, while ICAM-1 and AQP-1 positivity was observed in the alveolar septum vascular endothelium. Statistical analysis revealed a significant correlation between S100β and Hps70 immunoexpression and cerebral pathological features, between ICAM-1 immunoexpression and alveolar edema and pulmonary emphysema, and between AQP-1 immunoexpression and pulmonary emphysema. Conclusions: Our results add supplementary data to brain and lung pathological findings in hypothermia-related fatalities, with potential therapeutic value in hypothermia patients.

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Emerging Trends in the Use of Therapeutic Hypothermia as a Method for Neuroprotection in Brain Damage (Review)

Cited by 3 publications

References 123 publications

Role of PERK‐mediated pathway in the effect of mild hypothermia after cerebral ischaemia/reperfusion

Role of PERK‐mediated pathway in the effect of mild hypothermia after cerebral ischaemia/reperfusion

Impact of therapeutic hypothermia (whole body cooling) on severely asphyxiated term neonates: a prospective non-randomized comparative study in an Indian tertiary care setting

Advanced Diagnostic Tools in Hypothermia-Related Fatalities—A Pathological Perspective

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