Emerging trends in silk fibroin based nanofibers for impaired wound healing

Sabarees, Govindaraj; Tamilarasi, Ganesan Padmini; Velmurugan, V.; Alagarsamy, V.; Sibuh, Belay Zeleke; Sikarwar, Mohini; Taneja, Pankaj; Kumar, Akhilesh; Gupta, Piyush Kumar

doi:10.1016/j.jddst.2022.103994

Cited by 21 publications

(14 citation statements)

References 208 publications

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“…In general, the mechanical behaviors of tissue engineering scaffolds remarkably influence their biological function and efficiency 8,32 . Our results confirmed this, as our findings showed that cells in wounds covered with AM/SF scaffolds had higher expression of TGF‐β1 and TGF‐β3 at 7 days post‐grafting in comparison with the control group, resulting in better angiogenesis and epithelialization (Figure 10C).…”

Section: Discussionsupporting

confidence: 83%

“…In general, the mechanical behaviors of tissue engineering scaffolds remarkably influence their biological function and efficiency. 8,32 Our results confirmed this, as our findings showed that cells in wounds covered with AM/SF scaffolds had higher expression of TGF-β1 and TGF-β3 at 7 days post-grafting in comparison with the control group, resulting in better angiogenesis and epithelialization (Figure 10C). 8 In general, TGF-β with its three isoforms (TGF-β1, Àβ2, Àβ3) is involved in a number of processes in wound healing, including fibroblast proliferation, inflammation, collagen synthesis, stimulating angiogenesis and deposition and remodeling of the new extracellular matrix.…”

Section: F I G U R Esupporting

confidence: 80%

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Evaluation of an antibacterial peptide‐loaded amniotic membrane/silk fibroin electrospun nanofiber in wound healing

Moghaddam

Farhadie

Mirnejad

et al. 2023

International Wound Journal

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Antimicrobial peptides (AMPs) are among the compounds that have significant potential to deal with infectious skin wounds. Using wound dressings or skin scaffolds containing AMPs can be an effective way to overcome infections caused by antibiotic‐resistant strains. In this study, we developed an amniotic membrane‐based skin scaffold using silk fibroin to improve mechanical properties and CM11 peptide as an antimicrobial peptide. The peptide was coated on the scaffold using the soaking method. The fabricated scaffold was characterised by SEM and FTIR, and their mechanical strength, biodegradation, peptide release, and cell cytotoxicity analyses were performed. Then, their antimicrobial activity was measured against antibiotic‐resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus. The in vivo biocompatibility of this scaffold was evaluated by subcutaneously implanting it under the skin of the mouse and counting lymphocytes and macrophages in the implanted area. Finally, the regenerative ability of the scaffold was analyzed in the mouse full‐thickness wound model by measuring the wound diameter, H&E staining, and examining the expression rate of genes involved in the wound healing process. The developed scaffolds exerted an inhibiting effect on the bacteria growth, indicating their proper antimicrobial property. In vivo biocompatibility results showed no significant count of macrophages and lymphocytes between the test and control groups. The wound closure rate was significantly higher in the wound covered with fibroin electrospun‐amniotic membrane loaded with 32 μg/mL CM11, where the relative expression rates of collagen I, collagen III, TGF‐β1 and TGF‐β3 were higher compared with the other groups.

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Section: Discussionsupporting

confidence: 83%

Section: F I G U R Esupporting

confidence: 80%

Evaluation of an antibacterial peptide‐loaded amniotic membrane/silk fibroin electrospun nanofiber in wound healing

Moghaddam

Farhadie

Mirnejad

et al. 2023

International Wound Journal

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“…However, in this formulation, curcumin loading efficiency is only 7.2%, despite a 300‐fold rise in solubility, which could be due to the entrapment of curcumin by hydrophobic interactions inside the hydrophobic cavity of albumin 121 . The silk fibroin protein has recently gained much interest in biomedical applications because of its remarkable biocompatibility and multiple biological usages 122 . One study demonstrated delivery of curcumin to breast cancer cells by magnetic‐silk NPs 13 …”

Section: Nanotechnology‐based Curcumin Delivery Platformsmentioning

confidence: 99%

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Ahmad,

Ahmad

et al. 2024

Cell Biochemistry & Function

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Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness is limited due to poor absorption and rapid elimination from the body. Various curcumin derivatives have also shown anticancer potential in in‐vitro and in‐vivo models. Curcumin can target multiple signaling pathways involved in cancer development/progression or induce cancer cell death through apoptosis. In addition, curcumin and its derivatives could also enhance the effectiveness of conventional chemotherapy, radiation therapy and reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored to overcome the challenges associated with curcumin's delivery, increasing its overall efficacy. The use of an imaging system to track these formulations could also give beneficial information about the bioavailability and distribution of the nano‐curcumin complex. In conclusion, curcumin holds significant promise in the fight against cancer, especially in its nanoform, and could provide precise delivery to cancer cells without affecting normal healthy cells.

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“…Electrospun nanofibers are a novel class of materials with several potential applications in the biomedical sector. 46 Chitosan nanofibers are produced using the unique technology of electrospinning. Due to their high porosity and surface area, these nanofibers are ideal for biomedical applications.…”

Section: Review Materials Advancesmentioning

confidence: 99%

Advances in electrospun chitosan nanofiber biomaterials for biomedical applications

Tamilarasi,

Sabarees,

Manikandan

et al. 2023

Mater. Adv.

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Emerging trends in silk fibroin based nanofibers for impaired wound healing

Cited by 21 publications

References 208 publications

Evaluation of an antibacterial peptide‐loaded amniotic membrane/silk fibroin electrospun nanofiber in wound healing

Evaluation of an antibacterial peptide‐loaded amniotic membrane/silk fibroin electrospun nanofiber in wound healing

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Advances in electrospun chitosan nanofiber biomaterials for biomedical applications

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