2015
DOI: 10.1016/j.trac.2014.09.005
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Emerging trends in optical sensing of glycemic markers for diabetes monitoring

Abstract: In the past decade, considerable attention has been focused on the measurement of glycemic markers, such as glycated hemoglobin and glycated albumin, that provide retrospective indices of average glucose levels in the bloodstream. While these biomarkers have been regularly used to monitor long-term glucose control in established diabetics, they have also gained traction in diabetic screening. Detection of such glycemic markers is challenging, especially in a point-of-care setting, due to the stringent requirem… Show more

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Cited by 49 publications
(34 citation statements)
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References 81 publications
(55 reference statements)
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“…Although there is growing interest in, amongst others, glycated albumin and fructosamin as alternative markers of glycaemic control, HbA1c remains the gold standard biomarker of glycaemia [ 12 ]. It has been used as a universally accepted means for monitoring glycaemic control for more than three decades [ 13 ].…”
Section: Methodsmentioning
confidence: 99%
“…Although there is growing interest in, amongst others, glycated albumin and fructosamin as alternative markers of glycaemic control, HbA1c remains the gold standard biomarker of glycaemia [ 12 ]. It has been used as a universally accepted means for monitoring glycaemic control for more than three decades [ 13 ].…”
Section: Methodsmentioning
confidence: 99%
“…This in turn would cause a great reduction in sample variability, enabling to build calibration models easily, but is completely useless for a real-case application, where the individual variability is a major challenge. 48 In the case of°uorescence, the blood spectra are dominated by haemoglobin°uorescence from the RBCs. The blood-equivalent phantoms should be a viable model in this case for exploring the auto-°u orescence and photobleaching e®ects, 49 yet only to the extent when the°uorescence from chemical compounds in plasma can be neglected.…”
Section: Discussionmentioning
confidence: 99%
“…Raman Effect was first discovered in 1928 by Chandrasekhara Ramanan. In 1970 with the [88]. With this improvement higher intensity signals can be obtained [89].…”
Section: Descriptionmentioning
confidence: 99%