Emerging Trends in Nano‐Functionalized Scaffolds for Chronic Wound Healing

Abstract

This review discusses recent studies on the combination of nanoparticles (NPs) and biomaterials for the treatment of chronic wounds, especially diabetic foot ulcers (DFUs). This article provides a concise overview of several types of NPs. We will discuss how these NPs possess inherent characteristics that enhance the bioactivity, mechanical strength, tissue adhesion, and antibacterial properties of wound repairing scaffolds. Additionally, we explore their capacity to carry active substances and genes to the wound site. In this context, a comprehensive elucidation of various notable complexities associated with wound repair is provided, alongside corresponding strategies to mitigate them. So that, the adoption of NPs within wound dressings is advocated as a proficient technological approach to address each of these challenges. Furthermore, this article examines several physical and chemical techniques employed by researchers for the incorporation of NPs into scaffolds.