Emerging Trends in Curcumin Embedded Electrospun Nanofibers for Impaired Diabetic Wound Healing

Tamilarasi, Ganesan Padmini; Krishnan, Manikandan; Sabarees, Govindaraj; Gouthaman, Siddan; Alagarsamy, V.; Solomon, V. Raja

doi:10.3390/applnano3040015

Cited by 11 publications

(6 citation statements)

References 180 publications

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“…We stirred the resulting mixture at room temperature for 4 hours. 37 Subsequently, the PAN/CuO/curcumin solution was taken in a 5 ml syringe and inserted into a flow control electrospinning machine. This process was replicated several times and remarkable consistency in the synthesized samples was observed.…”

Section: Pan/cuo/curcumin Composite Nanofibers Using An Electrospinni...mentioning

confidence: 99%

Electrospun PAN/CuO/curcumin composite nanofiber mats for efficient antimicrobial face masks

Bansode,

Gagare,

Kondawar

et al. 2024

New J. Chem.

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Section: Pan/cuo/curcumin Composite Nanofibers Using An Electrospinni...mentioning

confidence: 99%

Electrospun PAN/CuO/curcumin composite nanofiber mats for efficient antimicrobial face masks

Bansode,

Gagare,

Kondawar

et al. 2024

New J. Chem.

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“…IL-10 is an inflammatory cytokine that is synthesized by macrophages, dendritic cells, T-helper cells, and activated T-helper cells ( 47 ). IL-10R is expressed most in immune cells, especially macrophages, where it inhibits antigen presentation and promotes phagocytosis.…”

Section: Cytokines In Wound Healingmentioning

confidence: 99%

Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes

Nirenjen¹,

Narayanan²,

Tamilanban³

et al. 2023

Front. Immunol.

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BackgroundImpaired wound healing is the most common and significant complication of Diabetes. While most other complications of Diabetes have better treatment options, diabetic wounds remain a burden as they can cause pain and suffering in patients. Wound closure and repair are orchestrated by a sequence of events aided by the release of pro-inflammatory cytokines, which are dysregulated in cases of Diabetes, making the wound environment unfavorable for healing and delaying the wound healing processes. This concise review provides an overview of the dysregulation of pro-inflammatory cytokines and offers insights into better therapeutic outcomes.Purpose of reviewAlthough many therapeutic approaches have been lined up nowadays to treat Diabetes, there are no proper treatment modalities proposed yet in treating diabetic wounds due to the lack of understanding about the role of inflammatory mediators, especially Pro-inflammatory mediators- Cytokines, in the process of Wound healing which we mainly focus on this review.Recent findingsAlthough complications of Diabetes mellitus are most reported after years of diagnosis, the most severe critical complication is impaired Wound Healing among Diabetes patients. Even though Trauma, Peripheral Artery Disease, and Peripheral Neuropathy are the leading triggering factors for the development of ulcerations, the most significant issue contributing to the development of complicated cutaneous wounds is wound healing impairment. It may even end up with amputation. Newer therapeutic approaches such as incorporating the additives in the present dressing materials, which include antimicrobial molecules and immunomodulatory cytokines is of better therapeutic value.SummaryThe adoption of these technologies and the establishment of novel therapeutic interventions is difficult since there is a gap in terms of a complete understanding of the pathophysiological mechanisms at the cellular and molecular level and the lack of data in terms of the assessment of safety and bioavailability differences in the individuals’ patients. The target-specific pro-inflammatory cytokines-based therapies, either by upregulation or downregulation of them, will be helpful in the wound healing process and thereby enhances the Quality of life in patients, which is the goal of drug therapy.

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“…Silk-based nanofibrous scaffolds loaded with asiaticoside enhanced the healing of lesions on diabetic induced rat models, and it also exhibited antibacterial effects against Pseudomonas aeruginosa and Staphylococcus aureus [ 48 ]. Curcumin is another phytochemical that has strong antioxidant, anti-inflammatory, and anti- infective characteristics [ 98 ]. Polycaprolactone-based nanofiber loaded with curcumin demonstrated antioxidant and anti-inflammatory effects in diabetic mouse models as compared to nanofibers of polycaprolactone alone [ 33 ].…”

Section: Current Trends In the Development Of Nanofibrous Scaffolds F...mentioning

confidence: 99%

Nanofibrous Scaffolds for Diabetic Wound Healing

Aliyu

Adeleke

2023

Pharmaceutics

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Chronic wounds are one of the secondary health complications that develop in individuals who have poorly managed diabetes mellitus. This is often associated with delays in the wound healing process, resulting from long-term uncontrolled blood glucose levels. As such, an appropriate therapeutic approach would be maintaining blood glucose concentration within normal ranges, but this can be quite challenging to achieve. Consequently, diabetic ulcers usually require special medical care to prevent complications such as sepsis, amputation, and deformities, which often develop in these patients. Although several conventional wound dressings, such as hydrogels, gauze, films, and foams, are employed in the treatment of such chronic wounds, nanofibrous scaffolds have gained the attention of researchers because of their flexibility, ability to load a variety of bioactive compounds as single entities or combinations, and large surface area to volume ratio, which provides a biomimetic environment for cell proliferation relative to conventional dressings. Here, we present the current trends on the versatility of nanofibrous scaffolds as novel platforms for the incorporation of bioactive agents suitable for the enhancement of diabetic wound healing.

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Emerging Trends in Curcumin Embedded Electrospun Nanofibers for Impaired Diabetic Wound Healing

Cited by 11 publications

References 180 publications

Electrospun PAN/CuO/curcumin composite nanofiber mats for efficient antimicrobial face masks

Electrospun PAN/CuO/curcumin composite nanofiber mats for efficient antimicrobial face masks

Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes

Nanofibrous Scaffolds for Diabetic Wound Healing

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