Emerging trends in combination strategies with phototherapy in advanced psoriasis management

Sreya, Ratnam; Nene, Shweta; Pathade, Vrushali; Singh, Shashi Bala; Srivastava, Saurabh

doi:10.1007/s10787-023-01257-2

Cited by 6 publications

(5 citation statements)

References 87 publications

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“…Psoriasis currently has no known cure, and the treatment relies mostly on managing its symptoms. The conventional treatment options encompass various approaches, including corticosteroids, vitamin D analogs, phototherapy, and systemic therapy ( 195 ). However, these treatments have some limitations and associated risks.…”

Section: Emerging Therapies Targeting Immune Cells In Psoriasismentioning

confidence: 99%

Immune cells in the epithelial immune microenvironment of psoriasis: emerging therapeutic targets

Li,

Lu,

Liu

et al. 2024

Front. Immunol.

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Psoriasis is a chronic autoimmune inflammatory disease characterized by erroneous metabolism of keratinocytes. The development of psoriasis is closely related to abnormal activation and disorders of the immune system. Dysregulated skin protective mechanisms can activate inflammatory pathways within the epithelial immune microenvironment (EIME), leading to the development of autoimmune-related and inflammatory skin diseases. In this review, we initially emphasized the pathogenesis of psoriasis, paying particular attention to the interactions between the abnormal activation of immune cells and the production of cytokines in psoriasis. Subsequently, we delved into the significance of the interactions between EIME and immune cells in the emergence of psoriasis. A thorough understanding of these immune processes is crucial to the development of targeted therapies for psoriasis. Finally, we discussed the potential novel targeted therapies aimed at modulating the EIME in psoriasis. This comprehensive examination sheds light on the intricate underlying immune mechanisms and provides insights into potential therapeutic avenues of immune-mediated inflammatory diseases.

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Section: Emerging Therapies Targeting Immune Cells In Psoriasismentioning

confidence: 99%

Immune cells in the epithelial immune microenvironment of psoriasis: emerging therapeutic targets

Li,

Lu,

Liu

et al. 2024

Front. Immunol.

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“…Psoriasis is a non-contagious, relapsing and chronic dermatological inflammatory skin disease. Current-treatment options for psoriasis include topical therapy, systemic therapy, biologics, phototherapy and PUVA (Sreya et al 2023 ). Such ultraviolet-based therapies, with phototherapy and PUVA, impacts Langerhans cells, cytokines, and adhesion molecules, while inhibiting the proliferation of keratinocytes and angiogenesis, along with T cell apoptosis (Menter et al 2010 ).…”

Section: Clinical Reviewmentioning

confidence: 99%

Psoralen: a narrative review of current and future therapeutic uses

Galiatsatos,

Maydan,

Macalpine

et al. 2024

J Cancer Res Clin Oncol

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Psoralen is a family of naturally occurring photoactive compounds found in plants that acquire potential cytotoxicity when activated by specific frequencies of electromagnetic waves. Psoralens penetrate the phospholipid cellular membranes and insert themselves between the pyrimidines of deoxyribonucleic acid (DNA). Psoralens are initially biologically inert and acquire photoreactivity when exposed to certain classes of electromagnetic radiation, such as ultraviolet light. Once activated, psoralens form mono- and di-adducts with DNA, leading to marked cell apoptosis. This apoptotic effect is more pronounced in tumor cells due to their high rate of cell division. Moreover, photoactivated psoralen can inhibit tyrosine kinase signaling and influence the immunogenic properties of cells. Thus, the cytotoxicity of photoactivated psoralen holds promising clinical applications from its immunogenic properties to potential anti-cancer treatments. This narrative review aims to provide an overview of the current understanding and research on psoralen and to explore its potential future pharmacotherapeutic benefits in specific diseases.

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“…The analysis of the degree of severity of skin disorders is majorly based on a few standards, including skin complexation, ethnicity, gender, age, genetics, clinical, geographical and environmental factors, hygiene, and socioeconomic status of a person . The skin disorders comprise a broad range of diseases such as atopic dermatitis, psoriasis, , melanoma, , vitiligo, and acne vulgaris . The success of currently available topical treatment modalities is hindered due to the presence of stratum corneum (SC), which acts as a solid barrier that restricts the effective penetration of therapeutics.…”

Section: Introductionmentioning

confidence: 99%

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Khairnar,

Phatale,

Shukla

et al. 2024

Mol. Pharmaceutics

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The various kinds of nanocarriers (NCs) have been explored for the delivery of therapeutics designed for the management of skin manifestations. The NCs are considered as one of the promising approaches for the skin delivery of therapeutics attributable to sustained release and enhanced skin penetration. Despite the extensive applications of the NCs, the challenges in their delivery via skin barrier (majorly stratum corneum) have persisted. To overcome all the challenges associated with the delivery of NCs, the microneedle (MN) technology has emerged as a beacon of hope. Programmable drug release, being painless, and its minimally invasive nature make it an intriguing strategy to circumvent the multiple challenges associated with the various drug delivery systems. The integration of positive traits of NCs and MNs boosts therapeutic effectiveness by evading stratum corneum, facilitating the delivery of NCs through the skin and enhancing their targeted delivery. This review discusses the barrier function of skin, the importance of MNs, the types of MNs, and the superiority of NC-loaded MNs. We highlighted the applications of NC-integrated MNs for the management of various skin ailments, combinational drug delivery, active targeting, in vivo imaging, and as theranostics. The clinical trials, patent portfolio, and marketed products of drug/NC-integrated MNs are covered. Finally, regulatory hurdles toward benchtop-to-bedside translation, along with promising prospects needed to scale up NC-integrated MN technology, have been deliberated. The current review is anticipated to deliver thoughtful visions to researchers, clinicians, and formulation scientists for the successful development of the MN-technology-based product by carefully optimizing all the formulation variables.

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Emerging trends in combination strategies with phototherapy in advanced psoriasis management

Cited by 6 publications

References 87 publications

Immune cells in the epithelial immune microenvironment of psoriasis: emerging therapeutic targets

Immune cells in the epithelial immune microenvironment of psoriasis: emerging therapeutic targets

Psoralen: a narrative review of current and future therapeutic uses

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

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