Emerging trends and hotspots in the links between the gut microbiota and MAFLD from 2002 to 2021: A bibliometric analysis

Li, Yixuan; Zhou, Yu; Wang, Liya; Lin, Xiaoqi; Mao, Menghan; Yin, Suqing; Zhu, Ling; Jiao, Yingfu; Yu, Weifeng; Gao, Po; Yang, Liqun

doi:10.3389/fendo.2022.990953

Cited by 9 publications

(10 citation statements)

References 49 publications

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“…The full record and cited references of all literature obtained from WoSCC were downloaded in TXT format [ 12 ]. The TXT files were then imported into CiteSpace (V6.3 R1 Advanced), VOSviewer (V1.6.19), and Scimago Graphica (V1.0.40) for further analysis [ 13 – 15 ].…”

Section: Methodsmentioning

confidence: 99%

Global research trend and hotspot in the low FODMAP diet: a bibliometric analysis

Xu,

Song,

et al. 2024

J Health Popul Nutr

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Background According to national guidelines, a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) is a second-line therapy option for irritable bowel syndrome (IBS) and improves functional intestinal symptoms. Numerous noteworthy results have been published in this field over the past fifteen years. This study aims to analyze the global research trend and hotspot of the low FODMAP diet research, and provide a comprehensive perspective and direction for researchers. Methods The Science Citation Index-Expanded of the Web of Science Core Collection (WoSCC) was used to identify low FODMAP diet-related articles and reviews. Three bibliometric programs (CiteSpace, VOSviewer, Scimago Graphic) were utilized to analyze and visualize the annual publications, authors, countries, institutions, journals, citations, and keywords. Results In total, 843 documents related to the low FODMAP diet research were published in 227 journals by 3,343 authors in 1,233 institutions from 59 countries. The United States, which was the most engaged nation in international collaboration, had the largest annual production and the fastest growth. The most productive organization was Monash University, and the most fruitful researcher was Gibson PR. Nutrients ranked first in terms of the number of published documents. The article “A diet low in FODMAPs reduces symptoms of irritable bowel syndrome” (Halmos EP, 2014) received the most co-citations. Keywords that appear frequently in the literature mainly involve two main aspects: the clinical efficacy evaluation and mechanism exploration of the low FODMAP diet. The term “gut microbiota” stands out as the most prominent keyword among the burst keywords that have remained prevalent till date. Conclusion The restriction stage of the low FODMAP diet is superior to other dietary therapies for IBS in terms of symptom response, but it has a negative impact on the abundance of gut Bifidobacteria and diet quality. Identification of biomarkers to predict response to the low FODMAP diet is of great interest and has become the current research hotspot.

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Section: Methodsmentioning

confidence: 99%

Global research trend and hotspot in the low FODMAP diet: a bibliometric analysis

Xu,

Song,

et al. 2024

J Health Popul Nutr

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“…Scientific evidence suggests that genetic factors strongly influence the development of MAFLD, and these factors overlap with those identified as factors for NAFLD and NASH (non-alcoholic steatohepatitis) ( 1 , 5 , 8 ). The patatin-like phospholipase domain-containing protein 3 gene ( PNPLA3 ), Membrane bound O-acyltransferase domain containing 7 gene ( MBOAT7 ), transmembrane 6 superfamily member 2 gene ( TM6SF2 ), and glucokinase regulator gene ( GCKR ) have been the most recognized genes involved in the pathogenesis of fatty liver diseases ( 9 , 10 ).…”

Section: Pathophysiological Processes In the Development Of Mafldmentioning

confidence: 99%

Development of LXR inverse agonists to treat MAFLD, NASH, and other metabolic diseases

Griffett

Burris

2023

Front. Med.

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Activation of LXR activity by synthetic agonists has been the focus of many drug discovery efforts with a focus on treatment of dyslipidemia and atherosclerosis. Many agonists have been developed, but all have been hindered due to their ability to efficaciously stimulate de novo lipogenesis. Here, we review the development of LXR inverse agonists that were originally optimized for their ability to enable recruitment of corepressors leading to silencing of genes that drive de novo lipogenesis. Such compounds have efficacy in animal models of MAFLD, dyslipidemia, and cancer. Several classes of LXR inverse agonists have been identified and one is now in clinical trials for treatment of severe dyslipidemia.

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“…Bibliometric analysis involves a timely and comprehensive review of publications during a specific period by analyzing their parameters such as the number of publications, authors, countries, and regions, references, keywords, etc. This approach provides a thorough overview of the intellectual landscape and helps researchers by highlighting the latest research trends (17)(18)(19). We aimed to analyze the publication trend of MAFLD from 2012 to 2021, to identify novel discoveries in pathogenesis and possible treatment measures, and to provide a panoramic overview of the research field for other researchers.…”

Section: Introductionmentioning

confidence: 99%

Emerging trends and hotspots in metabolic dysfunction-associated fatty liver disease (MAFLD) research from 2012 to 2021: A bibliometric analysis

et al. 2023

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BackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) has become the most common chronic liver disease. MAFLD is a major risk factor for end-stage liver disease including cirrhosis and primary liver cancer. The pathogenesis of MAFLD is complex and has not yet been clarified. To the best of our knowledge, few studies have conducted quantitative bibliometric analysis to evaluate published MAFLD research. In this study, we conducted a comprehensive analysis of MAFLD publications over the past decade to summarize the current research hotspots and predict future research directions in this field.MethodsArticles into MAFLD published from 2012 to 2021 were identified from the Science Citation Index-Expanded of Web of Science Core Collection. CiteSpace software, VOSviewer, the “bibliometrix” R package, and the Online Analysis Platform of Literature Metrology were used to analyze the current publication trends and hotspots.ResultsWe retrieved 13959 English articles about MAFLD published from 2012 to 2021. Primary sites of publication were dominated by the United States until 2014, when China became the source of most published MAFLD-related research papers. The United States was found to be the most engaged country in international cooperative efforts. Shanghai Jiao Tong University was the most productive institution. Loomba R was the most productive author with 123 articles. The co-cited keyword cluster tag showed ten main clusters: #0 liver fibrosis, #1 hemoglobin, #2 metabolic associated fatty liver disease, #3 egcg, #4 myocardial infarction, #5 heart disease, #6 pnpla3, #7 hepatocellular carcinoma, #8 noninvasive marker, and #9 children. Keyword burst analysis showed that gut microbiota was the highest-intensity research hotspot.ConclusionIn the past decade, the number of publications on MAFLD increased dramatically, especially in the last three years. Gut microbiota became an important research direction for etiological and therapeutic investigations into MAFLD. Insulin resistance was also a key factor in studying the development of MAFLD in recent years. Liver fibrosis was an important focus of disease development. This study provides systematic information, helps guide future research, and helps to identify mechanisms and new treatment methods for MAFLD.

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Emerging trends and hotspots in the links between the gut microbiota and MAFLD from 2002 to 2021: A bibliometric analysis

Cited by 9 publications

References 49 publications

Global research trend and hotspot in the low FODMAP diet: a bibliometric analysis

Global research trend and hotspot in the low FODMAP diet: a bibliometric analysis

Development of LXR inverse agonists to treat MAFLD, NASH, and other metabolic diseases

Emerging trends and hotspots in metabolic dysfunction-associated fatty liver disease (MAFLD) research from 2012 to 2021: A bibliometric analysis

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