Emerging Treatments for Recurrent Prostate Cancer

Hanna, Catherine; Jones, Robert

doi:10.2217/fon.15.228

Cited by 8 publications

(3 citation statements)

References 56 publications

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“…Prostate cancer, one of the most common malignancies in men, is the third leading cause of cancer-related deaths in men worldwide [1]. As prostate cancer cells are prone to malignant invasion and metastasis, current treatment for the disease is still facing difficulties [2]. Despite great advances in cancer treatment over the past decades, patients with advanced prostate cancer still suffer from the lack of effective treatments [3].…”

Section: Introductionmentioning

confidence: 99%

Effect of Sulfated Polysaccharide from Undaria pinnatifida (SPUP) on Proliferation, Migration, and Apoptosis of Human Prostatic Cancer

Zhu

et al. 2019

International Journal of Polymer Science

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Objective. To observe the effect of sulfated polysaccharide from Undaria pinnatifida (SPUP) on proliferation, migration, and apoptosis of human prostatic cancer. Methods. DU145 human prostate cancer cells were cultured in vitro, and the proliferation activity both in the control group and the SPUP treatment groups (25, 50, 100, 200 μg/ml) was measured by CCK-8 assay. The wound healing assay was conducted to detect the cell migration. Cell apoptosis was measured by flow cytometry. The protein and mRNA expressions of matrix metalloproteinase-9 (MMP-9) and apoptosis-related factor Bax were detected by qRT-PCR and Western blot. The expressions of cleaved caspase-3 and cleaved caspase-9 were also determined by Western blot. Results. (1) CCK-8 results showed that the proliferative activity of DU145 cells was significantly decreased with the increase of SPUP treatment concentration (P<0.05) in a dose-dependent manner and that the inhibitory effect of SPUP was most significant at 72 h (P<0.05) as compared with the control group; (2) the migration rate of SPUP-treated cells was significantly decreased (P<0.05) as compared with the control group. And the results of qRT-PCR and Western blot assays showed that SPUP inhibited the expression of MMP-9 in DU145 cells; (3) compared with the control group, the SPUP-treated groups had increased apoptosis of the cells. The expressions of apoptosis-related factors cleaved caspase-3, cleaved caspase-9, and Bax were upregulated (P<0.05), and the mRNA expression of Bax was increased (P<0.05). Conclusion. SPUP showed an antitumor activity in prostatic cancer, and the underlying mechanism may be pertaining to inhibition of migration, proliferation, and induction of apoptosis of cancer cells.

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Section: Introductionmentioning

confidence: 99%

Effect of Sulfated Polysaccharide from Undaria pinnatifida (SPUP) on Proliferation, Migration, and Apoptosis of Human Prostatic Cancer

Zhu

et al. 2019

International Journal of Polymer Science

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“…The distant recurrence risk of the elderly patients who suffered from breast cancer was increasing (4). Recurrent prostate cancer after radical treatment is likely to increase as more people undergo radical treatment (5).…”

Section: Introductionmentioning

confidence: 99%

Seasonal Variation in the Internet Searches for Cancer Recurrence: An Infodemiological Study

Lou

Zhang

et al. 2019

Preprint

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Background While few clinical and epidemiological studies have assessed how seasonality affects cancer recurrence, it has not been studied with the utility of the internet data. In this study, we aim to test whether cancer recurrence presents seasonality on a population level, utilizing internet search query data.Methods This infodemiological study used Google Trends to find query data for the term "cancer recurrence" from January 01, 2004, to December 31, 2018 in the USA, the UK, Canada, and Australia. Time series seasonal decomposition and the cosinor analysis were used to analyze and describe the seasonal trends for cancer recurrence.Results A general upward trend in UK and northern hemisphere were observed. Statistically significant seasonal trends on "cancer recurrence" in the USA (p=1.33×10 -5 ), the UK (p=0.012), and northern hemisphere (p=5.67×10 -7 ) were revealed by cosinor analysis, with a peak in early summer and nadir in early winter.Besides, a seasonal variation was also found in Australia (p=2.3×10 -4 ), with a peak in late summer and nadir in late winter. ConclusionsThe evidence from internet search query data showed a seasonal variation in cancer recurrence, with a peak in early summer(northern hemisphere)/late summer(southern hemisphere). Besides, the relative search volume of "cancer recurrence" appeared a general upward trend in UK and northern hemisphere in recent years.

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“…Prostate cancer (PCa), one of the most prevalent malignancies, is a common male malignancy and causes an increase in mortality worldwide every year [ 1 ]. Since the growth and metastasis of PCa cells is rapid, PCa is still unmanageable [ 2 ]. Although cancer therapies are well developed over the past decades, there is still short of effective therapeutic method for PCa [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-30a functions as tumor suppressor and inhibits the proliferation and invasion of prostate cancer cells by down-regulation of SIX1

Zhu

Zhang

et al. 2017

Human Cell

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Increasing reports have demonstrated that aberrant expression of microRNAs (miRNAs) is found in multiple human cancers. Many studies have shown that down-regulated level of miR-30a is in a variety of cancers including prostate cancer (PCa). However, the precise mechanisms of miR-30a in PCa have not been well explored. In this study, we investigated the biological functions and molecular mechanism of miR-30a in PCa cell lines, discussing whether it could be a therapeutic biomarker of PCa in the future. We found that miR-30a is down-regulated in PCa tissues and cell lines. Moreover, the low level of miR-30a was associated with increased expression of SIX1 in PCa tissues and cell lines. Up-regulation of miR-30a significantly inhibited proliferation of PCa cells. In addition, invasion of PCa cells was suppressed by overexpression of miR-30a. However, down-regulation of miR-30a promoted cell growth and invasion of PCa cells. Bioinformatics analysis predicted that the SIX1 was a potential target gene of miR-30a. Next, luciferase reporter assay confirmed that miR-30a could directly target SIX1. Consistent with the effect of miR-30a, down-regulation of SIX1 by siRNA inhibited proliferation and invasion of PCa cells. Overexpression of SIX1 in PCa cells partially reversed the effect of miR-30a mimic. In conclusion, introduction of miR-30a dramatically inhibited proliferation and invasion of PCa cells by down-regulating SIX1 expression, and that down-regulation of SIX1 was essential for inhibition of cell growth and invasion of PCa cells by overexpression of miR-30a.

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Emerging Treatments for Recurrent Prostate Cancer

Cited by 8 publications

References 56 publications

Effect of Sulfated Polysaccharide from Undaria pinnatifida (SPUP) on Proliferation, Migration, and Apoptosis of Human Prostatic Cancer

Effect of Sulfated Polysaccharide from Undaria pinnatifida (SPUP) on Proliferation, Migration, and Apoptosis of Human Prostatic Cancer

Seasonal Variation in the Internet Searches for Cancer Recurrence: An Infodemiological Study

MicroRNA-30a functions as tumor suppressor and inhibits the proliferation and invasion of prostate cancer cells by down-regulation of SIX1

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