Emerging threat of drug-resistant tuberculosis and trends in the era of COVID-19: A descriptive study from northwestern Nigeria

Dayyab, Farouq Muhammad; Iliyasu, Garba; Ahmad, Bashir; Umar, Ibrahim Aliyu; Shuaib, Nura Musa; Bajehson, Mamman; Daiyab, Ibrahim Muhammad; Akpala, Oji; Remilekun, Olaoye; Habib, Abdulrazaq G.

doi:10.1016/j.jctube.2022.100319

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…The rise in the RR-TB observed in this study may be a reflection of increase risk of contact of children with adults who have been reported to have increase drug resistance due to impact of COVID-19 on the access to TB diagnosis, treatment and preventive services. 15 , 18 The findings may possibly be the result of delayed diagnosis and access to treatment as a result of the influence of COVID-19 on children, which highlights the difficulties in the diagnosis of childhood tuberculosis. This finding implies a worsening of childhood TB indicators and an accompanying increase in mortality.…”

Section: Discussionmentioning

confidence: 99%

“…This may be explained in part by the prolonged isolation of individuals with non-specific respiratory symptoms that could be TB and the prolonged contact with family members. 7,9 Comparing the pre-COVID and COVID eras, Muhammad Dayyab et al found a significant increase in drug-resistant TB cases among 132 patients 15 Whereas most of the studies that evaluated the impact of COVID-19 on TB are in adult populations, the trends and impact in the pediatric population remain largely unknown due to paucity of data. This study therefore compared the trends in tuberculosis diagnoses between the pre-COVID era (January 2016 to December 2019) and the COVID-19 era (January 2020 to May 2022) in a large cohort of presumed TB cases in southwestern Nigeria.…”

Section: Introductionmentioning

confidence: 99%

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Trends in Rifampicin Resistance Among Children With Presumptive TB in the Pre-COVID and COVID-Era

Alao

Ogunbosi

Ibrahim

2023

Global Pediatric Health

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Publications on COVID-19’s impact on the global tuberculosis burden are from adult cohorts, pediatric data are lacking for inform decision. We compared the TB trends in southern Nigerian children in the pre-COVID-19 and COVID-19 era. This was a retrospective, cross-sectional study of early morning sputum/gastric washing or stool samples from children with presumptive TB evaluated using GeneXpert in a tertiary hospital from January 2016 to May 2022. Of the 20 589 persons screened for presumed TB in the pre-COVID-19 and the COVID-19 era, only 1104 (88.7%) of 1245 children had complete data for analysis. In the COVID era, a significantly higher number of children were presumed to have TB 755 (68.4%), P < .001. The overall incidence of MTB detected by Xpert MTB/RIF during the study period was 6.4% (71/1104). The incidence of MTB in the pre-COVID-19 era was 24/349 (6.9%), which was slightly higher than the COVID-19 era (47/755; 6.2%), P > .05). The annual trends of MTB detected peaked in 2019 [18/115; 15.7%] in the pre-COVID-19 era, then plummeted to 12/228 (5.3%) in 2020 in the COVID-19 era, and reached its all-time low of 6/160 (3.8%) in the first half of 2022, ( P < .001). The overall incidence of Rifampicin-resistant TB (RR-TB) was 2.8% among the MTB detected cases and all occurred in the COVID-19 era. This study found a significant decline in MTB diagnosis and in the emergence of RR-TB in the COVID-19 era. This necessitates re-prioritizing worldwide efforts to manage childhood tuberculosis, including increased testing, if the aim of eliminating tuberculosis by 2035 is to be met.

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Section: Discussionmentioning

confidence: 99%