Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration

Franco-O’Byrne, Daniel; Santamaría-García, Hernando; Migeot, Joaquín; Ibáñez, Agustín

doi:10.1007/7854_2024_471

Current Topics in Behavioral Neurosciences

2024

DOI: 10.1007/7854_2024_471

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Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration

Daniel Franco-O’Byrne,

Hernando Santamaría-García,

Joaquín Migeot

et al.

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2024

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References 170 publications

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Cardiometabolic state links neurovascular burden with brain structure and function across age: evidence from EEG and MRI

Franco-O’Byrne,

Castro-Laguardia,

Delgado

et al. 2024

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Aging affects brain structure and function alongside metabolic and vascular processes leading to energetic impairments. While local neurometabolic dysfunction in aging is well-documented, the influence of systemic cardiometabolic and vascular markers on brain structure and function remains less understood. We examine the link between cardiometabolic dysfunction (measured by an allostatic load index) and neurovascular burden (measured by white matter hyperintensities) with brain changes, including ventricular and hippocampal volume, as well as EEG activity, across age. Analyzing data from 196 healthy individuals across age (20-75 years), we found a significant positive correlation between allostatic load index and white-matter hyperintensities, irrespective of age. White-matter hyperintensities are also positively linked with ventricular enlargement, but not hippocampal atrophy. The allostatic load index mediated the relationship between white-matter hyperintensities and ventricular volume. Regarding brain function, changes in the spectral aperiodic exponent but not periodic alpha power were linked to white-matter hyperintensities and the allostatic load index. Such index mediated the relationship between spectral aperiodic exponent and white-matter hyperintensities. Thus, findings suggest that the cardiometabolic state, as measured by an allostatic load index, plays a crucial role in brain health across age, particularly influencing ventricular enlargement and increased aperiodic activity.

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Cardiometabolic state links neurovascular burden with brain structure and function across age: evidence from EEG and MRI

Franco-O’Byrne,

Castro-Laguardia,

Delgado

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

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Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration

Cited by 1 publication

References 170 publications

Cardiometabolic state links neurovascular burden with brain structure and function across age: evidence from EEG and MRI

Cardiometabolic state links neurovascular burden with brain structure and function across age: evidence from EEG and MRI

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