Emerging Technologies in Upper Extremity Surgery

Weller, William J.

doi:10.1016/j.ocl.2018.08.011

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…In the effort to ameliorate their performance as AC substitutes, different concentrations of PVA-based hydrogels are currently under investigation for their application in the orthopedic field. Weller [39] recently reported the use of 40% PVA hydrogel supports for treating thumb carpometacarpal arthroplasty, demonstrating that the tensile strength, compressive modulus, and coefficient of friction of the material highly resembled the mechanical properties of the native cartilage. Hendriks and collaborators [40] investigated a scaffold composed by macroporous and not biodegradable PVA hydrogel for the reparation of focal cartilage lesions.…”

Section: Pva-based Scaffolds For the Mechanical Support In Cartilage ...mentioning

confidence: 99%

Enhanced Biomechanical Properties of Polyvinyl Alcohol-Based Hybrid Scaffolds for Cartilage Tissue Engineering

et al. 2021

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Articular cartilage damage is a primary feature of osteoarthritis and other inflammatory joint diseases (i.e., rheumatoid arthritis). Repairing articular cartilage is highly challenging due to its avascular/aneural nature and low cellularity. To induce functional neocartilage formation, the tissue substitute must have mechanical properties which can adapt well to the loading conditions of the joint. Among the various biomaterials which may function as cartilage replacements, polyvinyl alcohol (PVA) hydrogels stand out for their high biocompatibility and tunable mechanical features. This review article describes and discusses the enrichment of PVA with natural materials (i.e., collagen, hyaluronic acid, hydroxyapatite, chitosan, alginate, extracellular matrix) ± synthetic additives (i.e., polyacrylic acid, poly-lactic-co-glycolic acid, poly(ethylene glycol) diacrylate, graphene oxide, bioactive glass) to produce cartilage substitutes with enhanced mechanical performance. PVA-based hybrid scaffolds have been investigated mainly by compression, tensile, friction, stress relaxation and creep tests, demonstrating increased stiffness and friction properties, and with cartilage-like viscoelastic behavior. In vitro and in vivo biocompatibility studies revealed positive outcomes but also many gaps yet to be addressed. Thus, recommendations for future research are proposed in order to prompt further progress in the fabrication of PVA-based hybrid scaffolds which increasingly match the biological and mechanical properties of native cartilage.

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Section: Pva-based Scaffolds For the Mechanical Support In Cartilage ...mentioning

confidence: 99%

Enhanced Biomechanical Properties of Polyvinyl Alcohol-Based Hybrid Scaffolds for Cartilage Tissue Engineering

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The former results in a severe loss of joint functions, while the latter faces the risk of complications such as prosthesis wear, loosening, and displacement. [ 10–12 ] Other clinical treatments: microfracture, forms fibrocartilage instead of durable hyaline cartilage; osteotomy, retards blood supply due to bone fracture; and arthroscopic debridement, has an unsatisfying long‐term effect and is not applicable in a narrow joint space. [ 13–17 ]…”

Section: Introductionmentioning

confidence: 99%

PVA‐Based Hydrogels: Promising Candidates for Articular Cartilage Repair

Chen

Song

Wang

et al. 2021

Macromolecular Bioscience

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The complex, gradient physiological structure of articular cartilage is a severe hindrance of its self‐repair, leaving the clinical treatment of cartilage defects a demanding issue to be addressed. Currently applied tissue engineering treatments and traditional non‐tissue engineering treatments have different limitations, for example, cell dedifferentiation, immune rejection, and prosthesis‐related complications. Thus, studies have been focusing on seeking promising candidates for novel cartilage repair methods. Polyvinyl alcohol (PVA) hydrogels with excellent biocompatibility and tunable material properties have become the alternatives. For pure PVA hydrogels, the mechanical strength and lubricity are not capable of replacing articular cartilage until proper modifications are done. This paper summarizes the research progress in PVA hydrogels, including the preparation, modification, and cartilage‐repair‐aimed biomimetic improvements. Design guidance of PVA hydrogels is put forward as assistance to functional hydrogel preparation. Finally, the prospects and main obstacles of PVA hydrogels are discussed.

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Protocol of a Nerve Neurotmesis Sciatic Repair using Polyvinyl Alcohol Biofilm in Wistar Rats

Lacerda Brito,

Oliveira,

Andrade

et al. 2023

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

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Background Animal models are commonly used to assess the efficacy of new materials to be employed in the surgical repair of a nerve injury. However, there is no published surgical repair protocol for sciatic nerve neurotmesis in rats. Objective To produce and evaluate a protocol for the tubing technique using a polyvinyl alcohol biofilm after sciatic nerve neurotmesis. Methods Eighteen rats were randomized into 3 groups (n = 6 per group): control group - CG, neurotmesis group - NG, and neurotmesis biofilm group - NBG. The NG and NBG animals were submitted to neurotmesis of the sciatic nerve at 60 days of life, followed by suture of the nerve stumps; in the NBG, the animals had the suture involved by polyvinyl alcohol biofilm. A descriptive evaluation of the surgical technique was performed after the experimental period. The Shapiro-Wilk normality test was used for body weight, and analysis of variance (ANOVA) with Bonferroni posthoc (p < 0.05) was applied. Results All groups showed good repair of the skin and muscle sutures; however, 33.30% of the CG presented disruption of skin points. Furthermore, 16.70% of the stumps were not structurally aligned and 33.30% had neuromas in the NG, while in the NBG, all stumps were aligned and none of them had neuroma . Conclusions The present study was able to produce a protocol with high reproducibility in view of the mechanical stability, targeting of the nerve stumps, muscle healing, the low frequency of skin breakage and the low complexity level of the technique, and it can be used in future studies that aim to evaluate other biomaterials for nerve repair in rats.

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Emerging Technologies in Upper Extremity Surgery

Cited by 5 publications

References 32 publications

Enhanced Biomechanical Properties of Polyvinyl Alcohol-Based Hybrid Scaffolds for Cartilage Tissue Engineering

Enhanced Biomechanical Properties of Polyvinyl Alcohol-Based Hybrid Scaffolds for Cartilage Tissue Engineering

PVA‐Based Hydrogels: Promising Candidates for Articular Cartilage Repair

Protocol of a Nerve Neurotmesis Sciatic Repair using Polyvinyl Alcohol Biofilm in Wistar Rats

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