Emerging technologies for cancer therapy using accelerated particles

Graeff, Christian; Volz, Lennart; Durante, Marco

doi:10.1016/j.ppnp.2023.104046

Cited by 15 publications

(7 citation statements)

References 204 publications

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“…Graeff et al 144 . consider technology development for PT as a whole (using protons or heavier ions) and summarise increasing use of PT as requiring it to be ‘cheaper, more conformal and faster’.…”

Section: Costs and Cost Effectiveness?mentioning

confidence: 99%

“…Continuous improvements in design, construction and capability of accelerators and other PT technology promise to decrease the size and capital cost of facilities 22,27,36–38,144–148 . Figure 5a illustrates the layout of the MedAustron hybrid (CIRT and PBT) particle therapy facility 149 .…”

Section: Costs and Cost Effectiveness?mentioning

confidence: 99%

“…5b and c), while continuing advances point to further reductions 27,148 . These and many other developments promise increased process efficiency and decreased facility operational costs, coupled with improving accuracy and personalisation of PT 22,27,31,144,145,148 . They include accelerator control efficiency, higher dose rates, faster energy and beamline switching, flexible beam direction selection, and beam verification and measurement equipment and methods, as well as treatment planning algorithms and software systems, online imaging systems and image‐guidance, 22,150–152 motion management methods, 24,153,154 adaptive CIRT 149,155 and the application of machine learning/artificial intelligence to many aspects of PT 156,157 …”

Section: Costs and Cost Effectiveness?mentioning

confidence: 99%

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The rationale for a carbon ion radiation therapy facility in Australia

Thwaites,

Prokopovich,

Garrett

et al. 2023

J of Medical Radiation Sci

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Australia has taken a collaborative nationally networked approach to achieve particle therapy capability. This supports the under‐construction proton therapy facility in Adelaide, other potential proton centres and an under‐evaluation proposal for a hybrid carbon ion and proton centre in western Sydney. A wide‐ranging overview is presented of the rationale for carbon ion radiation therapy, applying observations to the case for an Australian facility and to the clinical and research potential from such a national centre.

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Section: Costs and Cost Effectiveness?mentioning

confidence: 99%

Section: Costs and Cost Effectiveness?mentioning

confidence: 99%

Section: Costs and Cost Effectiveness?mentioning

confidence: 99%

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The rationale for a carbon ion radiation therapy facility in Australia

Thwaites,

Prokopovich,

Garrett

et al. 2023

J of Medical Radiation Sci

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“…Particle imaging is currently being developed as a promising tool for planning CT imaging and online treatment verification in particle therapy, where high precision is a key requirement (Graeff et al 2023 ). The rationale for particle imaging is to use the particle beam both for applying the treatment and acquiring the image, reducing registration and image conversion uncertainties.…”

Section: Introductionmentioning

confidence: 99%

Focus stacking single-event particle radiography for high spatial resolution images and 3D feature localization

Volz,

Graeff,

Durante

et al. 2024

Phys. Med. Biol.

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We demonstrate a novel focus stacking technique to improve spatial resolution of single-event particle radiography (pRad), and exploit its potential for 3D feature detection. Focus stacking, used typically in optical photography and microscopy, is a technique to combine multiple images with different focal depths into a single super-resolution image. Each pixel in the final image is chosen from the image with the largest gradient at that pixel’s position. pRad data can be reconstructed at different depths in the patient based on an estimate of each particle’s trajectory (called distance-driven binning; DDB). For a given feature, there is a depth of reconstruction for which the spatial resolution of DDB is maximal. Focus stacking can hence be applied to a series of DDB images reconstructed from a single pRad acquisition for different depths, yielding both a high-resolution projection and information on the features’ radiological depth at the same time. We demonstrate this technique with Geant4 simulated pRads of a water phantom (20 cm thick) with five bone cube inserts at different depths (1x1x1 cm3) and a lung cancer patient. For proton radiography of the cube phantom, focus stacking achieved a median resolution improvement of 136% compared to a state-of-the-art maximum likelihood pRad reconstruction algorithm and a median of 28% compared to DDB where the reconstruction depth was the center of each cube. For the lung patient, resolution was visually improved, without loss in accuracy. The focus stacking method also enabled to estimate the depth of the cubes within few millimeters accuracy, except for one shallow cube, where the depth was underestimated by 2.5cm. Focus stacking utilizes the inherent 3D information encoded in pRad by the particle’s scattering, overcoming current spatial resolution limits. It further opens possibilities for 3D feature localization. Therefore, focus stacking holds great potential for future pRad applications.

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“…In recent years, C-ion physics research has tended toward investigations addressing treatment precision, speed, and cost [ 8 ], while the field of radiobiology actively studies the impact of C-ion irradiation on the tumor microenvironment and signaling pathways [ 7 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them?

Sokol,

Durante

2023

Cancers

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Hypoxia, which is associated with abnormal vessel growth, is a characteristic feature of many solid tumors that increases their metastatic potential and resistance to radiotherapy. Carbon-ion radiation therapy, either alone or in combination with other treatments, is one of the most promising treatments for hypoxic tumors because the oxygen enhancement ratio decreases with increasing particle LET. Nevertheless, current clinical practice does not yet fully benefit from the use of carbon ions to tackle hypoxia. Here, we provide an overview of the existing experimental and clinical evidence supporting the efficacy of C-ion radiotherapy in overcoming hypoxia-induced radioresistance, followed by a discussion of the strategies proposed to enhance it, including different approaches to maximize LET in the tumors.

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Emerging technologies for cancer therapy using accelerated particles

Cited by 15 publications

References 204 publications

The rationale for a carbon ion radiation therapy facility in Australia

The rationale for a carbon ion radiation therapy facility in Australia

Focus stacking single-event particle radiography for high spatial resolution images and 3D feature localization

Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them?

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