Emerging Technologies for Biocatalysis in the Pharmaceutical Industry

Lewis, Russell D.; France, Scott P.; Martínez, Carlos A.

doi:10.1021/acscatal.3c00812

Cited by 17 publications

(5 citation statements)

References 54 publications

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“…In the pharmaceutical industry, biocatalysis has become crucial for the preparation of several APIs, mainly due to the sustainability and efficiency associated with these types of processes. Biocatalysts have the great advantage of conferring unparalleled selectivity during the synthesis of pharmaceuticals [ 6 ]. Furthermore, when optimized it can lead to robustness and scalable reactions.…”

Section: Deep Eutectic Systemsmentioning

confidence: 99%

How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?

Domingues,

Duarte,

Jesus

2024

Pharmaceuticals

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Chemists in the medicinal chemistry field are constantly searching for alternatives towards more sustainable and eco-friendly processes for the design and synthesis of drug candidates. The pharmaceutical industry is one of the most polluting industries, having a high E-factor, which is driving the adoption of more sustainable processes not only for new drug candidates, but also in the production of well-established active pharmaceutical ingredients. Deep eutectic systems (DESs) have emerged as a greener alternative to ionic liquids, and their potential to substitute traditional organic solvents in drug discovery has raised interest among scientists. With the use of DESs as alternative solvents, the processes become more attractive in terms of eco-friendliness and recyclability. Furthermore, they might be more effective through making the process simpler, faster, and with maximum efficiency. This review will be focused on the role and application of deep eutectic systems in drug discovery, using biocatalytic processes and traditional organic chemical reactions, as new environmentally benign alternative solvents. Furthermore, herein we also show that DESs, if used in the pharmaceutical industry, may have a significant effect on lowering production costs and decreasing the impact of this industry on the quality of the environment.

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Section: Deep Eutectic Systemsmentioning

confidence: 99%

How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?

Domingues,

Duarte,

Jesus

2024

Pharmaceuticals

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“…On that basis, the last two decades have witnessed a compounded growth of biocatalysis in the synthesis of building blocks in the pharmaceutical, flavor, and fragrance sectors. More enzyme classes have been involved including hydrolases, oxidoreductase, transaminases, and lyases [8]. The incorporation of biocatalysis into industrial processes is continuously expanding and their use may potentially become one of the major pillars for Green Chemistry.…”

Section: Introductionmentioning

confidence: 99%

Biocatalysis for the Synthesis of Active Pharmaceutical Ingredients in Deep Eutectic Solvents: State-of-the-Art and Prospects

Zhang,

Domínguez de María,

Kara

2024

Catalysts

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Biocatalysis holds immense potential for pharmaceutical development as it enables synthetic routes to various chiral building blocks with unparalleled selectivity. Therein, solvent and water use account for a large contribution to the environmental impact of the reactions. In the spirit of Green Chemistry, a transition from traditional highly diluted aqueous systems to intensified non-aqueous media to overcome limitations (e.g., water shortages, recalcitrant wastewater treatments, and low substrate loadings) has been observed. Benefiting from the spectacular advances in various enzyme stabilization techniques, a plethora of biotransformations in non-conventional media have been established. Deep eutectic solvents (DESs) emerge as a sort of (potentially) greener non-aqueous medium with increasing use in biocatalysis. This review discusses the state-of-the-art of biotransformations in DESs with a focus on biocatalytic pathways for the synthesis of active pharmaceutical ingredients (APIs). Representative examples of different enzyme classes are discussed, together with a critical vision of the limitations and discussing prospects of using DESs for biocatalysis.

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“…This approach has turned out to be extremely widespread and currently, many groups worldwide are focusing on developing enzyme cascade synthesis to find new innovative synthetic routes to various important chiral building blocks and bioactive molecules. [8][9][10][11][12] Living cells can be considered as "synthetic factories" given that multiple enzymes work in a relay to catalyze the biosynthesis of various molecules with the highest order of complexity without interfering with, or hampering each other's reactivity. Using this approach, scientists have come up with the idea of combining multiple enzymes in a single pot to catalyze a relay of transformations.…”

Section: Introductionmentioning

confidence: 99%

Evaluating Multienzyme Cascade Routes for Pharmaceutically Relevant Molecules

Naik,

Dheeraj,

Jeevani

et al. 2024

Eur J Org Chem

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The constant demand for sustainable approaches to pharmaceutical synthesis has thrived the enzyme catalysis (biocatalysis) field. The most sought‐after features like high specificity, environmentally benign, and biodegradable nature have rendered enzymatic processes predominantly eco‐friendly. Owing to these merits, biocatalysis is now being developed extensively to exploit their applications in designing alternate and sustainable synthetic routes for manufacturing pharmaceuticals, in line with green chemistry principles. Further, combining multiple enzymes in one‐pot is a highly efficient methodology as it eliminates intermediate isolation, shifts equilibrium in the forward direction, and proceeds in ambient aqueous conditions. This review highlights the importance of recently developed multienzyme cascade synthesis of pharmaceutically important bioactive molecules by relating them with their well‐known chemical route.

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Emerging Technologies for Biocatalysis in the Pharmaceutical Industry

Cited by 17 publications

References 54 publications

How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?

How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?

Biocatalysis for the Synthesis of Active Pharmaceutical Ingredients in Deep Eutectic Solvents: State-of-the-Art and Prospects

Evaluating Multienzyme Cascade Routes for Pharmaceutically Relevant Molecules

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