Emerging Techniques in Brain Tumor Imaging: What Radiologists Need to Know

Kim, Minjae; Kim, Ho Sung

doi:10.3348/kjr.2016.17.5.598

Cited by 35 publications

(35 citation statements)

References 84 publications

(122 reference statements)

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“…DSC PWI might be utilized in estimating not only the microvessel area (MVA) but also 4 important parameters of lesion included cerebral blood volume (CBV), cerebral blood flow (CBF), mean time transit (MTT) and time to peak (TTP) derived from multidynamic T2*weighted gradient recalled echo sequence as seen in figure 1 [1][2][3][4][5][6].…”

Section: Group a Dsc Pwimentioning

confidence: 99%

“…Perfusion, one of the most crucial physiologic and pathophysiologic features of tissue, can be investigated non-invasively and non-ionzingly by magnetic resonance imaging (MRI) [1][2][3][4][5]. Currently, we have some different perfusionweighted imaging (PWI) sequences to achieve perfusion-related parameters using external tracer such as gadolinium-based contrast agent (GBCE) or substances and internal tracer such as blood or water molecule.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, we have some different perfusionweighted imaging (PWI) sequences to achieve perfusion-related parameters using external tracer such as gadolinium-based contrast agent (GBCE) or substances and internal tracer such as blood or water molecule. In practice, we have two groups of PWI: group A with contrast enhancement: (1) dynamic susceptibility contrast (DSC) PWI; (2) semiquantitative dynamic contrast-enhanced (DCE) PWI; (3) quantitative dynamic contrast-enhanced (DCE) PWI; and (4) dynamic glucose-enhanced (DGE) PWI and group B without contrast enhancement: (1) arterial spin labelling (ASL) and (2) amide proton transfer (APT) [1][2][3][4][5]. In this short communication, we aimed to introduce clinical approach of these PWI applications.…”

Section: Introductionmentioning

confidence: 99%

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Clinical approach of perfusion-weighted imaging

Duc¹,

Huy²,

Bang³

et al. 2018

Imaging-Medicine

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Perfusion is one of the most important parameters affected on the diagnosis, treatment planning, and disease response to therapy. There are some discriminative kinds of perfusion-weighted imaging (PWI) such as dynamic susceptibility contrast PWI, semiquantitative dynamic contrast-enhanced PWI, quantitative dynamic contrast-enhanced PWI, dynamic glucose-enhanced PWI, arterial spin labelling and amide proton transfer. In this short communication, we aimed to introduce clinical approach of these PWI types.

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Section: Group a Dsc Pwimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical approach of perfusion-weighted imaging

Duc¹,

Huy²,

Bang³

et al. 2018

Imaging-Medicine

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“…For this reason, the timeliness of research data is essential; indeed, some journals provide submitting authors with specific guidelines in this regard (1). Moreover, in radiology, data timeliness may be especially important since the field relies heavily on new technology particularly digital technology (234567), which develops and changes faster than in other disciplines. Thus, the timeliness of data in radiology journals may be an important indicator of quality or impact, and the present study analyzed and compared several representative general radiology journals in terms of the age of the data published therein.…”

Section: Introductionmentioning

confidence: 99%

Age of Data in Contemporary Research Articles Published in Representative General Radiology Journals

2018

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ObjectiveTo analyze and compare the age of data in contemporary research articles published in representative general radiology journals.Materials and MethodsWe searched for articles reporting original research studies analyzing patient data that were published in the print issues of the Korean Journal of Radiology (KJR), European Radiology (ER), and Radiology in 2017. Eligible articles were reviewed to extract data collection period (time from first patient recruitment to last patient follow-up) and age of data (time between data collection end and publication). The journals were compared in terms of the proportion of articles reporting the data collection period to the level of calendar month and regarding the age of data.ResultsThere were 50, 492, and 254 eligible articles in KJR, ER, and Radiology, respectively. Of these, 44 (88%; 95% confidence interval [CI]: 75.8–94.8%), 359 (73%; 95% CI: 68.9–76.7%), and 211 (83.1%; 95% CI: 78–87.2%) articles, respectively, provided enough details of data collection period, revealing a significant difference between ER and Radiology (p = 0.002). The age of data was significantly greater in KJR (median age: 826 days; range: 299–2843 days) than in ER (median age: 570 days; range: 56–4742 days; p < 0.001) and Radiology (median age: 618; range: 75–4271 days; p < 0.001).ConclusionKorean Journal of Radiology did not fall behind ER or Radiology in reporting of data collection period, but showed a significantly greater age of data than ER and Radiology, suggesting that KJR should take measures to improve the timeliness of its data.

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“…Quantitative APT parameters have been proposed as prognostic indicators of brain gliomas by reflecting the cellular proliferation levels that correlate with the Ki-67 protein (6) and as a sensitive biomarker of treatment responses (7) in experimental and clinical studies. As molecular events precede the morphologic changes, observing changes in endogenous molecules can provide valuable information in treatment response (8). This is why APT imaging could be a promising imaging biomarker in tumor studies despite its inherent technical limitations.…”

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confidence: 99%

Can Amide Proton Transfer MRI Distinguish Benign and Malignant Head and Neck Tumors?

Choi¹

2018

Radiology

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H ead and neck cancer is a major type of cancer, affecting 50 000 new patients in the United States every year (1). Patients with early head and neck cancers can undergo radiation therapy or surgery. Important causes of an unfavorable outcome in patients with advanced head and neck cancer can be delayed diagnosis and tardy salvage treatment at disease recurrence (1). Imaging goals for head and neck tumors include differential diagnosis of malignant tumors from benign lesions, establishment of tumor extent and size, and assessment of nodal disease. For these purposes, MRI is the preferred modality to evaluate head and neck areas because of its better contrast resolution and feasibility. Functional MRI modalities, such as diffusion-weighted (DW) imaging and dynamic contrast material-enhanced MRI provide anatomic and physiologic information, including tumor cellularity and vascularity for tumor characterization (2). However, there are several limitations to these techniques. DW images are affected by patient motion distortion and susceptibility difference in head and neck areas. Dynamic contrast-enhanced MRI is limited by the nonspecific nature of vessel leakage, which can lead to many false-negative and false-positive results (2). Thus, different imaging modalities have been applied to head and neck tumors to acquire more physiologic and molecular information.In this issue of Radiology, Law and colleagues (3) used amide proton transfer (APT) MRI to characterize head and neck tumors. They also investigated whether APT imaging has a complimentary role to DW imaging for this purpose. They enrolled 117 patients, 70 with nasopharyngeal undifferentiated carcinoma, 26 with squamous cell carcinoma, eight with non-Hodgkin lymphoma, and 13 with benign salivary gland tumors. Normal tissues were examined in 25 patients. They found that mean APT of malignant tumors (2.40% 6 0.97 [standard deviation]) was higher than that of brain (1.13% 6 0.43), muscle (0.23% 6 0.73), and benign (1.32% 6 1.20) tumors (P , .001), but no differences were observed between malignant groups. In addition, by adding APT parameters to the apparent diffusion coefficient (ADC) parameters, the area under the receiver operating characteristic curve could increase from a range of 0.84-0.87 to a range of 0.89-0.96 (P = .13 to P = .30).APT MRI is as an emerging molecular MRI technique based on the chemical exchange processes between free water and mobile amide protons of protein and peptide backbones. APT MRI depicts small variations in amide proton concentration associated with the tumor protein and peptide backbones. It is a potential tool of tumor detection and characterization, especially in the brain (4). In this study, Law et al asked, "Can APT MRI be feasible and useful in the evaluation of head and neck tumors?" The previous study by this author group (4) showed the feasibility and repeatability of performing APT MRI in head and neck areas at a clinical field strength of 3 T in healthy volunteers. In addition, they found that head and neck tumors had ...

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Emerging Techniques in Brain Tumor Imaging: What Radiologists Need to Know

Cited by 35 publications

References 84 publications

Clinical approach of perfusion-weighted imaging

Clinical approach of perfusion-weighted imaging

Age of Data in Contemporary Research Articles Published in Representative General Radiology Journals

Can Amide Proton Transfer MRI Distinguish Benign and Malignant Head and Neck Tumors?

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