Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives

Chen, Minhua; Shou, Zhang; Xue, Jing; Chen, Yingjun

doi:10.1080/10717544.2022.2089294

Cited by 19 publications

(10 citation statements)

References 186 publications

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“…Smart nano-systems, as described by Chen et al [188], can react to specific internal or external stimuli or be target-specific, through the presence of small molecules or peptides. Wang et al [189] produced a nano-system to carry specific reactive oxygen species (ROS)-responsive elements to treat P. aeruginosa in a mouse infection model.…”

Section: Smart Nano-systemsmentioning

confidence: 99%

New Antimicrobial Strategies to Treat Multi-Drug Resistant Infections Caused by Gram-Negatives in Cystic Fibrosis

Scoffone,

Barbieri,

Irudal

et al. 2024

Antibiotics

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People with cystic fibrosis (CF) suffer from recurrent bacterial infections which induce inflammation, lung tissue damage and failure of the respiratory system. Prolonged exposure to combinatorial antibiotic therapies triggers the appearance of multi-drug resistant (MDR) bacteria. The development of alternative antimicrobial strategies may provide a way to mitigate antimicrobial resistance. Here we discuss different alternative approaches to the use of classic antibiotics: anti-virulence and anti-biofilm compounds which exert a low selective pressure; phage therapies that represent an alternative strategy with a high therapeutic potential; new methods helping antibiotics activity such as adjuvants; and antimicrobial peptides and nanoparticle formulations. Their mechanisms and in vitro and in vivo efficacy are described, in order to figure out a complete landscape of new alternative approaches to fight MDR Gram-negative CF pathogens.

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Section: Smart Nano-systemsmentioning

confidence: 99%

New Antimicrobial Strategies to Treat Multi-Drug Resistant Infections Caused by Gram-Negatives in Cystic Fibrosis

Scoffone,

Barbieri,

Irudal

et al. 2024

Antibiotics

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“…(Singh 2022). Due to their extensive surface area, gold nanoparticles (Au NPs) have unique electrical, magnetic, and catalytic properties and vast biological applications (Chen et al 2022;Carrapiço et al 2023;Mitri et al 2023). Au NPs are adaptable and resourceful and can be modi ed into various shapes depending on the need to switch from one task to another (Manjubaashini and Thangadurai 2023).…”

Section: Introductionmentioning

confidence: 99%

Grewia asiatica leaves extract assisted green synthesis of gold nanoparticles and study of their antibacterial, antioxidant and photocatalytic potential

Maryam,

Akhter,

Qamar

et al. 2024

Preprint

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The environmental issues generated by industrial advancement and human activities are serious and must not be overlooked. Bio-nanotechnology has emerged as a solution for producing biosynthetic nanomaterials to address environmental issues. The current work describes for the first time an economical and environmentally benign method of producing gold nanoparticles utilizing Grewia asiatica (GAAuNPs). The optimal AuNPs were produced using a gold ion concentration of 1 mM and a metal-to-extract ratio of 1:1. The resulting nanoparticles were analyzed and characterized using X-ray crystallography, FTIR, SEM, EDX, and UV visible spectroscopy. The catalytic methylene blue (MB) dye degradation properties, antibacterial and biofilm inhibition abilities, and antioxidant properties of the synthesized particles were investigated. The Au NPs demonstrated efficient catalytic degradation against MB and completely degraded it in 8 minutes. The NPs also exhibited potent biofilm inhibition against E. coli and S. aureus that was close to the standard and was more antioxidant than the standard. The findings highlight G. asiatica as a suitable, inexpensive biosource for biofabricating GAAuNPs with extensive multifunctional uses. To conclude, GAAuNPs' ability to degrade organic pollutants and eradicate pathogens provides a cost-effective and environmentally benign remedy to tackle contemporary pollutants.

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“…To contextualize the discussion, we begin by elucidating the mechanisms underlying antimicrobial resistance and the limitations of conventional antibiotic therapies. By understanding the factors driving the emergence and spread of AMR, it becomes apparent why innovative approaches, such as nanoparticle-based antimicrobials, are urgently needed (Chen et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles as Surrogates of Antibiotics: A Comprehensive Review

Choudhary,

Parveen

2024

Int. J. Res. Publ. Rev.

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The growing threat of antimicrobial resistance has necessitated the exploration of alternative strategies to combat bacterial infections. Nanoparticles have emerged as promising candidates to fill this void, offering unique properties that can augment or even replace traditional antibiotics. This review paper provides a comprehensive overview of the current state of research regarding nanoparticles as surrogates of antibiotics. It begins with an examination of the mechanisms underlying antimicrobial resistance and the limitations of conventional antibiotic therapies. Subsequently, it delves into the various types of nanoparticles utilized in antimicrobial applications, including metallic, polymeric, lipid-based, and hybrid nanoparticles. The paper discusses in detail the mechanisms of action by which nanoparticles exert antimicrobial effects, such as membrane disruption, reactive oxygen species generation, and interference with bacterial biofilms. Furthermore, it explores the factors influencing the antimicrobial efficacy of nanoparticles, including size, shape, surface chemistry, and functionalization strategies. The review also addresses key challenges and considerations in the development and application of nanoparticle-based antimicrobial agents, including toxicity, biocompatibility, scalability, and regulatory approval. Additionally, recent advancements in nanoparticle-based delivery systems and combination therapies are highlighted, showcasing their potential to enhance efficacy and mitigate resistance development. Overall, this review provides valuable insights into the burgeoning field of nanoparticle-based antimicrobial strategies and offers perspectives on future directions for research and clinical translation.

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Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives

Cited by 19 publications

References 186 publications

New Antimicrobial Strategies to Treat Multi-Drug Resistant Infections Caused by Gram-Negatives in Cystic Fibrosis

New Antimicrobial Strategies to Treat Multi-Drug Resistant Infections Caused by Gram-Negatives in Cystic Fibrosis

Grewia asiatica leaves extract assisted green synthesis of gold nanoparticles and study of their antibacterial, antioxidant and photocatalytic potential

Nanoparticles as Surrogates of Antibiotics: A Comprehensive Review

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