Emerging sensing platforms based on Cucurbit[<i>n</i>]uril functionalized gold nanoparticles and electrodes

Ma, Tao; Chang, Shuai; He, Jin; Liang, Feng

doi:10.1039/d3cc04851a

Chem. Commun.

2024

DOI: 10.1039/d3cc04851a

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Emerging sensing platforms based on Cucurbit[n]uril functionalized gold nanoparticles and electrodes

Tao Ma,

Shuai Chang,

Jin He

et al.

Abstract: Cucurbit[n]urils (CB[n]s, n=5–8, 10, and 14), one of the synthetic macrocycles with unique host-guest properties, have triggered increasing research interest in recent years. Gold nanoparticles (Au NPs) and electrodes stand...

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Cited by 5 publications

References 124 publications

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Unimolecular Cucurbit[7]uril‐Based Indicator Displacement Assay with Dual Signal‐Readout for the Detection of Drugs

Picchetti,

Balli,

Baker

et al. 2024

Analysis & Sensing

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Point‐of‐care diagnostics relies on optical and electrochemical sensors to develop devices that are both compact and cost‐effective. Therefore, the search for new design principles for chemosensors that enable multiple signal outputs is a particularly interesting concept. In this work, we present an unimolecular chemosensor based on cucurbit[7]uril that combines two signal readouts ‐ namely fluorescent and electrochemical signals ‐ in a single chemosensor design. This is achieved by utilizing the tunable fluorescence and the electrochemical properties of the reporter molecule, which depend on whether or not it is engulfed by the cucurbit[7]uril cavity. By setting up an assay using the dual readout chemosensor, illicit drug formulations containing pancuronium bromide or nicotine can be detected at low micromolar concentrations (0 – 100 μM). This assay is compatible with standard fluorescence plate readers and electrochemical devices, including commercially available screen‐printed electrodes (SPEs). Overall, the chemosensor presented in this study represents a significant advance in the development of cucurbit[7]uril chemosensors, characterized by multimodal detection capabilities. It uniquely combines traditional optical and electrochemical detection methods in a single molecular design.

show abstract

Unimolecular Cucurbit[7]uril‐Based Indicator Displacement Assay with Dual Signal‐Readout for the Detection of Drugs

Picchetti,

Balli,

Baker

et al. 2024

Analysis & Sensing

View full text Add to dashboard Cite

show abstract

A nanocomposite film with layer-by-layer self-assembled gold nanospheres driven by cucurbit[7]uril for the selective transport of L-tryptophan and lysozyme

Zhang,

Qu,

Noruzi

et al. 2024

Chinese Chemical Letters

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Ligand dominating the catalytic performance of cucurbit[6]uril modified gold nanoparticles for electrocatalytic CO2 reduction

Ma,

Qiu,

Tao

et al. 2024

Journal of Alloys and Compounds

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Emerging sensing platforms based on Cucurbit[n]uril functionalized gold nanoparticles and electrodes

Abstract: Cucurbit[n]urils (CB[n]s, n=5–8, 10, and 14), one of the synthetic macrocycles with unique host-guest properties, have triggered increasing research interest in recent years. Gold nanoparticles (Au NPs) and electrodes stand...

Cited by 5 publications

References 124 publications

Unimolecular Cucurbit[7]uril‐Based Indicator Displacement Assay with Dual Signal‐Readout for the Detection of Drugs

Unimolecular Cucurbit[7]uril‐Based Indicator Displacement Assay with Dual Signal‐Readout for the Detection of Drugs

A nanocomposite film with layer-by-layer self-assembled gold nanospheres driven by cucurbit[7]uril for the selective transport of L-tryptophan and lysozyme

Ligand dominating the catalytic performance of cucurbit[6]uril modified gold nanoparticles for electrocatalytic CO2 reduction

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