Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer

Kong, Deok-Hoon; Kim, Young Kwan; Kim, Mi Ra; Jang, Ji Hye; Lee, Sukmook

doi:10.3390/ijms19041057

Cited by 446 publications

(342 citation statements)

References 121 publications

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“…Vascular cell adhesion molecule 1 (VCAM-1) is an inducible glycoprotein, and E-selectin is a soluble cell adhesion molecule. Both molecules are primarily expressed in the endothelium [ 4 , 5 , 6 , 7 ]. The serum levels of soluble VCAM-1 appear to be correlated with the degree of atherosclerosis and may be used for diagnosing the early stages of the condition [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Methotrexate and Adalimumab Decrease the Serum Levels of Cardiovascular Disease Biomarkers (VCAM-1 and E-Selectin) in Plaque Psoriasis

et al. 2020

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Background and objectives: The shared pathogenesis of psoriasis and atherosclerosis may be determined by assaying the levels of endothelial activation molecules. This study aimed at evaluating vascular cell adhesion molecule 1 (VCAM-1) and E-selectin serum concentrations, and atherosclerosis severity in patients with plaque psoriasis. It also aimed to determine the effects of methotrexate/adalimumab treatment for 12 weeks on the plasma levels of the aforementioned molecules. Materials and Methods: The study included 34 psoriasis patients (17 treated with methotrexate and 17 treated with adalimumab) and eight controls. The 10-year risk of a fatal cardiovascular disease, body mass index, Psoriasis Area and Severity Index, and body surface area were calculated for each subject. VCAM-1 and E-selectin levels were determined via an enzyme-linked immunosorbent assay at baseline and after 12 weeks. Results: Baseline E-selectin and VCAM-1 levels were higher in the adalimumab group than in the methotrexate and control groups. VCAM-1 levels decreased in the adalimumab (p = 0.02) and methotrexate groups (p = 0.008), while E-selectin levels decreased in the methotrexate group (p = 0.004). Conclusions: The results indicate a correlation between systemic psoriasis treatment and E-selectin and VCAM-1 plasma concentrations, which may be associated with the risk of cardiovascular disease development.

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Section: Introductionmentioning

confidence: 99%

Methotrexate and Adalimumab Decrease the Serum Levels of Cardiovascular Disease Biomarkers (VCAM-1 and E-Selectin) in Plaque Psoriasis

et al. 2020

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“…Nitric oxide generated by iNOS is closely implicated in the development of various types of liver disease such as hepatic fibrosis and cirrhosis (Iwakiri and Kim, 2015). Both VCAM and VEGFC have been shown to regulate chronic vascular inflammation in various disease models (Hsu et al, 2019;Kong et al, 2018). In summary, our results suggest that keratins, functioning as cytoplasmic anchors for protein kinases, regulate the nuclear localization of p38 and thereby could affect a number of signal transduction pathways and the expression of correlated genes.…”

Section: Disrupted Docking Interaction Between P38 and A Liver Diseasmentioning

confidence: 68%

Keratins regulate Hsp70-mediated nuclear localization of p38 mitogen-activated protein kinase

Lee

Kim

Lim

et al. 2019

Journal of Cell Science

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Intermediate filament protein keratin 8 (K8) binds to heat shock protein 70 (Hsp70) and p38 MAPK, and is phosphorylated at Ser74 by p38α (MAPK14, hereafter p38). However, a p38 binding site on K8 and the molecular mechanism of K8-p38 interaction related to Hsp70 are unknown. Here, we identify a p38 docking site on K8 (Arg148/149 and Leu159/161) that is highly conserved in other intermediate filaments. A docking-deficient K8 mutation caused increased p38-Hsp70 interaction and enhanced p38 nuclear localization, indicating that the p38 dissociated from mutant K8 makes a complex with Hsp70, which is known as a potential chaperone for p38 nuclear translocation. Comparison of p38 MAPK binding with keratin variants associated with liver disease showed that the K18 I150V variant dramatically reduced binding with p38, which is similar to the effect of the p38 docking-deficient mutation on K8. Because the p38 docking site on K8 (Arg148/149 and Leu159/ 161) and the K18 Ile150 residue are closely localized in the parallel K8/K18 heterodimer, the K18 I150V mutation might interfere with K8-p38 interaction. These findings show that keratins, functioning as cytoplasmic anchors for p38, modulate p38 nuclear localization and thereby might affect a number of p38-mediated signal transduction pathways.

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“…VCAM-1 (Vascular Cell Adhesion Molecule 1) overexpression is related to angiogenesis and metastasis in cancer, including GC (Kong et al, 2018); in which both local expression in gastric tissue and serum levels are directly associated with poor prognosis (Velikova et al, 1997;Ding et al, 2003). In children, Maciorkowska et al, described that serum concentrations of VCAM-1 were higher in symptomatic children with H. pyloriassociated gastritis compared to non-infected children; they also compared children with positive IgG against H. pylori but with no active gastric infection (Maciorkowska et al, 2005), showing that serum levels of VCAM-1 correlate with H. pylori-induced gastric inflammation and damage.…”

Section: Cell-adhesion Proteinsmentioning

confidence: 99%

Gastric Damage and Cancer-Associated Biomarkers in Helicobacter pylori-Infected Children

et al. 2020

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Helicobacter pylori (H. pylori) is well-known to be involved in gastric carcinogenesis, associated with deregulation of cell proliferation and epigenetic changes in cancerrelated genes. H. pylori infection is largely acquired during childhood, persisting long-term in about half of infected individuals, a subset of whom will go on to develop peptic ulcer disease and eventually gastric cancer, however, the sequence of events leading to disease is not completely understood. Knowledge on carcinogenesis and gastric damage-related biomarkers is abundant in adult populations, but scarce in children. We performed an extensive literature review focusing on gastric cancer related biomarkers identified in adult populations, which have been detected in children infected with H. pylori. Biomarkers were related to expression levels (RNA or protein) and/or methylation levels (DNA) in gastric tissue or blood of infected children as compared to non-infected controls. In this review, we identified 37 biomarkers of which 24 are over expressed, three are under expressed, and ten genes are significantly hypermethylated in H. pylori-infected children compared to healthy controls in at least 1 study. Only four of these biomarkers (pepsinogen I, pepsinogen II, gastrin, and SLC5A8) have been studied in asymptomatically infected children. Importantly, 13 of these biomarkers (β-catenin, C-MYC, GATA-4, DAPK1, CXCL13, DC-SIGN, TIMP3, EGFR, GRIN2B, PIM2, SLC5A8, CDH1, and VCAM-1.) are consistently deregulated in infected children and in adults with gastric cancer. Future studies should be designed to determine the clinical significance of these changes in infection-associated biomarkers in children and their persistence over time. The effect of eradication therapy over these biomarkers in children if proven significant, could lead to modifications in treatment guidelines for younger populations, and eventually promote the development of preventive strategies, such as vaccination, in the near future.

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Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer

Cited by 446 publications

References 121 publications

Methotrexate and Adalimumab Decrease the Serum Levels of Cardiovascular Disease Biomarkers (VCAM-1 and E-Selectin) in Plaque Psoriasis

Methotrexate and Adalimumab Decrease the Serum Levels of Cardiovascular Disease Biomarkers (VCAM-1 and E-Selectin) in Plaque Psoriasis

Keratins regulate Hsp70-mediated nuclear localization of p38 mitogen-activated protein kinase

Gastric Damage and Cancer-Associated Biomarkers in Helicobacter pylori-Infected Children

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