Emerging roles of tripartite motif family proteins (TRIMs) in breast cancer
Jianing Cao,
Mengdi Yang,
Duancheng Guo
et al.
Abstract:Breast cancer (BC) is the most common malignant tumor worldwide. Despite enormous progress made in the past decades, the underlying mechanisms of BC remain further illustrated. Recently, TRIM family proteins proved to be engaged in BC progression through regulating various aspects. Here we reviewed the structures and basic functions of TRIM family members and first classified them into three groups according to canonical polyubiquitination forms that they could mediate: K48‐ only, K63‐ only, and both K48‐ and … Show more
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