Emerging roles of the neural adaptor FE65 in neurite outgrowth

Li, Wei; Chan, Wai Wa Ray; Jck, Ngo; Lau, Kwok‐Fai

doi:10.4103/1673-5374.241449

Cited by 4 publications

(2 citation statements)

References 18 publications

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Section: Fe65 Associated Actin Cytoskeleton Regulatorsmentioning

confidence: 99%

“…The interaction of Fe65 and ELMO1 was identified by the group of Dr. Lau [ 54 , 58 , 145 , 146 ], showing the binding of ELMO1 to the most N-terminal domain of Fe65, not present in Fe65L2. Interestingly, Fe65 binding releases the intramolecular autoinhibition of ELMO1, which in turn recruits DOCK1 [ 54 , 58 , 146 , 147 ]. Furthermore, Fe65 was shown to form presumably a quadripartite complex with Arf6 and ELMO1/DOCK1 facilitating retargeting of ELMO1 to the plasma membrane via involvement of Arf6 [ 58 ].…”

Section: Fe65 Associated Actin Cytoskeleton Regulatorsmentioning

confidence: 99%

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Fe65: A Scaffolding Protein of Actin Regulators

Augustin

Kins

2021

Cells

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The scaffolding protein family Fe65, composed of Fe65, Fe65L1, and Fe65L2, was identified as an interaction partner of the amyloid precursor protein (APP), which plays a key function in Alzheimer’s disease. All three Fe65 family members possess three highly conserved interaction domains, forming complexes with diverse binding partners that can be assigned to different cellular functions, such as transactivation of genes in the nucleus, modulation of calcium homeostasis and lipid metabolism, and regulation of the actin cytoskeleton. In this article, we rule out putative new intracellular signaling mechanisms of the APP-interacting protein Fe65 in the regulation of actin cytoskeleton dynamics in the context of various neuronal functions, such as cell migration, neurite outgrowth, and synaptic plasticity.

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