Emerging roles of suppressor of cytokine signaling 3 in human cancers

Dai, Lirui; Li, Zian; Tao, Yiran; Liang, Wulong; Hu, Weihua; Zhou, Shaolong; Fu, Xudong; Wang, Xinjun

doi:10.1016/j.biopha.2021.112262

Cited by 30 publications

(28 citation statements)

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“…IRGPI consists of six genes: SOCS3, TCF7L2, and TSLP, which are protective factors, and NPR3, ANO6, and HMGB3 which are risk factors. SOCS3 gene is a tumor suppressor that plays a role in the regulation of various signaling pathways and immune molecules, thereby preventing malignant proliferation, invasion, and metastasis ( 16 , 17 ). SOCS3 silences the expression of its downstream gene, C-myc, and reduces the possibility of tumor occurrence ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Development of a Novel Immune-Related Gene Prognostic Index for Breast Cancer

et al. 2022

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ObjectiveTo construct an immune-related gene prognostic index (IRGPI) for breast cancer (BC) and investigate its prognostic specificity and the molecular and immune characteristics.MethodsBC hub genes were identified from The Cancer Genome Atlas and immune-related databases using weighted gene co-expression network analysis (WGCNA). IRGPI was constructed using univariate, LASSO, and multivariate regression analyses, and was validated with GSE58812 and GSE97342 in the Gene Expression Omnibus database (GEO). At the same time, we evaluated the predictive ability of IRGPI for different BC subtypes. Subsequently, the molecular and immune characteristics, clinical relevance, and benefits of immune checkpoint inhibitor treatment were analyzed for different IRGPI subgroups.ResultsIRGPI consisted of six genes: SOCS3, TCF7L2, TSLP NPR3, ANO6, and HMGB3. The IRGPI 1-, 5-, and 10-years area under curve (AUC) values were 0.635, 0.752, and 0.753, respectively, indicating that IRGPI has good potential in predicting the long-term survival of BC patients, consistent with the results in the GEO cohort. IRGPI showed good predictive power in four different breast cancer subtypes: ER positive, PR positive, HER2 positive and triple-negative (P<0.01). Compared with the low-IRGPI group, the high-IRGPI group had a worse prognosis and a lower degree of immune infiltrating cells (p < 0.05). IRGPI showed specificity in distinguishing age, TNM stage, ER, and HER2 statuses, and our study found that the high-IRGPI group had low tumor immune dysfunction and exclusion (TIDE), microsatellite instability (MSI), and T cell dysfunction scores (p < 0.05). In addition, compared with the TIDE and TIS models, showed that the AUCs of IRGPI were better during the 5-year follow-up.ConclusionIRGPI can be used as an independent prognostic indicator of breast cancer, providing a method for monitoring the long-term treatment of BC.

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Section: Discussionmentioning

confidence: 99%

Development of a Novel Immune-Related Gene Prognostic Index for Breast Cancer

et al. 2022

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“…The decreased expression of SOCS3 promoted the proliferation, migration, invasion, anti-anoikis apoptosis, and gemcitabine resistance of A549 cells by negatively regulating the JAK/STAT signaling pathway [ 54 ]. Downregulation of SOCS3 expression was associated with the TNM stage and poor prognosis of patients with lung cancer [ 55 , 56 ]. TRAIP was a new regulator in DNA damage response and was associated with cancer development in LUAD [ 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Ubiquitin-Related Gene-Pair Signatures for Predicting Tumor Microenvironment Infiltration and Drug Sensitivity of Lung Adenocarcinoma

Jia

et al. 2022

Cancers

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Lung adenocarcinoma (LUAD) is a common pathological type of lung cancer worldwide, and new biomarkers are urgently required to guide more effective individualized therapy for patients. Ubiquitin-related genes (UbRGs) partially participate in the initiation and progression of lung cancer. In this study, we used ubiquitin-related gene pairs (UbRGPs) in tumor tissues to access the function of UbRGs in overall survival, immunocyte infiltration, and tumor mutation burden (TMB) of patients with LUAD from The Cancer Genome Atlas (TCGA) database. In addition, we constructed a prognostic signature based on six UbRGPs and evaluated its performance in an internal (TCGA testing set) and an external validation set (GSE13213). The prognostic signature revealed that risk scores were negatively correlated with the overall survival, immunocyte infiltration, and expression of immune checkpoint inhibitor-related genes and positively correlated with the TMB. Patients in the high-risk group showed higher sensitivity to partially targeted and chemotherapeutic drugs than those in the low-risk group. This study contributes to the understanding of the characteristics of UbRGPs in LUAD and provides guidance for effective immuno-, chemo-, and targeted therapy.

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“…Inflammatory signalling characterized by regulation of mediators and modulators play crucial role in hepatic microenvironment and injury ( Abdulkhaleq et al, 2018 , Huang et al, 2020 ). The balance between pro-inflammatory and anti-inflammatory responses can determine the development and progression of HCC ( Dai et al, 2021 ). Here, especially the regulation of SOCS molecules as modulators of inflammatory responses have drawn attention in the pathogenesis of HCC ( Fujimoto and Naka, 2010 , Rossa et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%