Emerging roles of pathogen-secreted host mimics in plant disease development

Wu, Dousheng; Wang, Lifeng; Zhang, Yong; Bai, Lianyang; Yu, Feng

doi:10.1016/j.pt.2021.09.007

Cited by 11 publications

(6 citation statements)

References 123 publications

(153 reference statements)

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“…Common ways for pathogens to take advantage of plant RNases are e.g., by utilizing small RNA fragments produced during host RNA degradation as signaling molecules to regulate their own gene expression or as a source of nutrients to facilitate their own growth 20, 21 . Moreover, pathogens can directly manipulate the expression and activity of RNases to promote their own survival and proliferation 22 or produce RNA molecules that mimic host transcripts, allowing them to evade detection and degradation by host RNases 23 . Regardless of initial RLXL transcription, all plants swiftly moved towards its suppression following the pathogen inoculation (Fig.…”

Section: Discussionmentioning

confidence: 99%

QTL mapping in field plant populations reveals a genetic basis for frequency- and spatially-specific fungal pathosystem resistance

Baraniecka,

Gase,

Pradhan

et al. 2024

Preprint

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Fungal pathogens pose significant challenges to agro-ecosystem productivity. The wild tobacco,Nicotiana attenuata, has been grown for over two decades at an experimental field station in its native habitat, leading to the emergence of a high-mortality sudden wilt disease caused by aFusarium-Alternariapathosystem. By using an Advanced Intercross Recombinant Inbred Line (AI-RIL) mapping population ofN. attenuataplanted in the infected field site, we found two significant loci associated with plant susceptibility to the fungi. A functional characterization of several genes in these loci identifiedRLXL(intracellular ribonuclease LX-like) as an important factor underlying plant pathogen resistance. Virus-induced silencing ofRLXLreduced leaf wilting in plants inoculated with anin vitroculture ofFusariumspecies. Assessing the significance of theRLXL-associated allele in mixed field populations indicated that, among 4-plant subpopulations, those harboring a single plant with theRLXL-deficiency allele exhibited the highest survival rates. Within these populations, a livingRLXL-deficient plant improved the survival ofRLXL-producing plants located diagonally, while the mortality of the adjacent plants remained as high as in all other subpopulations. Taken together, these findings provide evidence for the genetic basis for a frequency- and spatially-dependent population pathogen resistance mechanism.Significance statementPlant pathogen resistance studies predominantly focus on single genes that reduce pathogenicity in individual plants, aiming to apply these findings to agricultural monocultures. On the other hand, ecologists have observed for decades that greater diversity drives plant population resistance and resilience to pathogens. More studies are needed to identify and characterize loci with positive effects conferred through their frequency in plant populations. We combine quantitative genetics, molecular techniques, and ecologically-informed mixed field populations to identify a novel intracellular ribonuclease LX-like (RLXL) gene with a frequency- and position-dependent effect for plant resistance. To our knowledge, this is the first detailed link between plant population protection and various percentages of plants with an allele representingRLXLpresence or absence.

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Section: Discussionmentioning

confidence: 99%

QTL mapping in field plant populations reveals a genetic basis for frequency- and spatially-specific fungal pathosystem resistance

Baraniecka,

Gase,

Pradhan

et al. 2024

Preprint

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“…This may be a biased view, arising from the fact that all known signaling peptides were discovered in a few angiosperm model plants, preventing us from appreciating the full range of peptide signals; the possibility that novel peptide signals evolved within and outside of angiosperms has not yet been fully explored. Interestingly, sequences similar to plant peptide signals of both the CRP and PTMP classes are also found in organisms that interact with plants, including symbiotic fungi as well as bacterial, fungal, and nematode pathogens (Wu et al, 2021; Le Marquer et al, 2019). For example, small peptides that resemble CEP [C‐TERMINALLY ENCODED PEPTIDE; (Ohyama et al, 2008)], CLE, IDA, or PSY were found in molecules secreted by plant parasitic nematodes (Gheysen and Mitchum, 2019; Yimer et al, 2023) (Figure 1B).…”

Section: Small Signaling Peptides In Land Plantsmentioning

confidence: 99%

“…as bacterial, fungal, and nematode pathogens(Wu et al, 2021;Le Marquer et al, 2019). For example, small peptides that resemble CEP [C-TERMINALLY ENCODED PEPTIDE;(Ohyama et al, 2008)], CLE, IDA, or PSY were found in molecules secreted by plant parasitic nematodes(Gheysen and Mitchum, 2019;Yimer et al, 2023) (Figure…”

mentioning

confidence: 99%

Land plant peptide signaling: What we know—and don't know—about its evolution

Furumizu,

Shinohara

2024

Physiologia Plantarum

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The availability of genome sequences from diverse algal and plant taxa combined with the refinement of comparative genomics tools has begun to reveal how land plant genomes were shaped through duplication, repeat expansion, and gene family gains and losses. Of particular note is a large increase in the complexity and variety of signaling systems in land plants. Among these, signaling through small peptide ligand‐receptor interactions has been considered one of the major innovations during land plant evolution. First discovered in angiosperms as mediators of various cell‐to‐cell communication processes, peptide signaling studies have been expanded to non‐angiosperms, including bryophytes. Recent studies point to both common and unique roles for peptide signaling in distantly related species, raising interesting questions about how peptide signaling systems evolved and diversified. While the origin of peptide signaling systems remains elusive, progress in sequencing algal genomes offers clues to understanding the evolution of peptide receptors. This article discusses recent studies of small peptide‐mediated signaling systems and highlights current gaps in our knowledge and new avenues for research, which could help us address how peptide signaling systems evolved and contributed to plant terrestrialization.

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“…To counteract PTI, the pathogen secretes numerous T3Es into the plant cell to inhibit the PTI response. However, intracellular receptors that have evolved in plants, NLRs, can detect the activity of intracellular T3Es and thus activate the ETI immune response, inactivating the T3Es ( Chiang and Coaker, 2015 ; Cui et al, 2015 ; Wu et al, 2021 ). However, some effector proteins can also successfully inhibit ETI, rendering immunity ineffective ( Rufián et al, 2018 ; Nakano et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Induced defense strategies of plants against Ralstonia solanacearum

et al. 2023

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Plants respond to Ralstonia solanacearum infestation through two layers of immune system (PTI and ETI). This process involves the production of plant-induced resistance. Strategies for inducing resistance in plants include the formation of tyloses, gels, and callose and changes in the content of cell wall components such as cellulose, hemicellulose, pectin, lignin, and suberin in response to pathogen infestation. When R. solanacearum secrete cell wall degrading enzymes, plants also sense the status of cell wall fragments through the cell wall integrity (CWI) system, which activates deep-seated defense responses. In addition, plants also fight against R. solanacearum infestation by regulating the distribution of metabolic networks to increase the production of resistant metabolites and reduce the production of metabolites that are easily exploited by R. solanacearum. We review the strategies used by plants to induce resistance in response to R. solanacearum infestation. In particular, we highlight the importance of plant-induced physical and chemical defenses as well as cell wall defenses in the fight against R. solanacearum.

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Emerging roles of pathogen-secreted host mimics in plant disease development

Cited by 11 publications

References 123 publications

QTL mapping in field plant populations reveals a genetic basis for frequency- and spatially-specific fungal pathosystem resistance

QTL mapping in field plant populations reveals a genetic basis for frequency- and spatially-specific fungal pathosystem resistance

Land plant peptide signaling: What we know—and don't know—about its evolution

Induced defense strategies of plants against Ralstonia solanacearum

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