Emerging roles of MicroRNAs in osteonecrosis of the femoral head

Li, Zheng; Yang, Bo; Weng, Xisheng; Tse, Gary; Chan, Matthew T. V.; Wu, William Ka Kei

doi:10.1111/cpr.12405

Cited by 45 publications

(42 citation statements)

References 49 publications

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“…EVs that are released by cells such as BMSCs and osteoblasts can deliver miRs that are engaged in the development of ONFH. 28,29 For instance, miR-122-5p overexpressed in BMSC-derived EVs suppresses the expression of RTK signalling antagonist 2 to inhibit the occurrence of ONFH through RTK/ Ras/mitogen-activated protein kinase axis. 30 Moreover, miR-26a-CD34-EVs strengthened the osteogenic differentiation of BMSCs and the integrity of trabecular bone in glucocorticoids-induced ONFH.…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, we identified that the expression of miR‐148a‐3p was poorly expressed in ONFH, and miR‐148a‐3p in EVs derived from BMSCs promoted the proliferation and osteogenic differentiation of BMSCs in ONFH. EVs that are released by cells such as BMSCs and osteoblasts can deliver miRs that are engaged in the development of ONFH 28,29 . For instance, miR‐122‐5p overexpressed in BMSC‐derived EVs suppresses the expression of RTK signalling antagonist 2 to inhibit the occurrence of ONFH through RTK/Ras/mitogen‐activated protein kinase axis 30 .…”

Section: Discussionmentioning

confidence: 99%

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microRNA‐148a‐3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head

Huang

et al. 2020

J Cellular Molecular Medi

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

microRNA‐148a‐3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head

Huang

et al. 2020

J Cellular Molecular Medi

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“…Recently, the potential for using miRNA to treat ONFH has attracted increasing attention 35 . Yamasaki et al 36 .…”

Section: Discussionmentioning

confidence: 99%

AAV-Anti-miR-214 Prevents Collapse of the Femoral Head in Osteonecrosis by Regulating Osteoblast and Osteoclast Activities

Wang

Sun

Ling

et al. 2019

Molecular Therapy - Nucleic Acids

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Osteonecrosis of the femoral head, an intractable but common disease that eventually triggers collapse of the femoral head, is characterized by increased osteoclast activity and markedly decreased osteoblast activity in the necrotic region of the femoral head. MicroRNA (miRNA)-214 (miR-214) may play important roles in vertebrate skeletal development by inhibiting osteoblast function by targeting activating transcription factor 4 (ATF4) and promoting osteoclast function via phosphatase and tensin homolog (PTEN). This study revealed significantly increased levels of miR-214 in necrotic regions, with commensurate changes in the numbers of its target cells (both osteoblasts and osteoclasts). To investigate whether targeting miR-214 could prevent femoral head collapse, we constructed an adeno-associated virus (AAV)-associated anti-miR-214 (AAV-anti-miR-214) and evaluated its function in vivo. AAV-anti-miR-214 promoted osteoblast activity and diminished osteoclast activity, effectively preventing collapse of the femoral head in a rat model of osteonecrosis.

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“…Deregulation of miRNAs contributes to ONFH-N [ 22 ], but the differentially expressed circulating miRNAs in patients with ONFH-N receiving conservative therapy are unknown. Therefore, this study aimed to determine the differentially expressed miRNAs in patients with ONFH-N receiving conservative treatments.…”

Section: Discussionmentioning

confidence: 99%

Differentially Expressed MicroRNAs in Conservatively Treated Nontraumatic Osteonecrosis Compared with Healthy Controls

Wei

Wang³

et al. 2018

BioMed Research International

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Deregulation of microRNAs (miRNAs) contributes to nontraumatic osteonecrosis of the femoral head (ONFH-N), but the differentially expressed circulating miRNAs in patients with ONFH-N receiving nonsurgical therapy are unknown. This study aimed to determine the miRNAs expression profile of patients with ONFH-N receiving conservative treatments. This was a case-control prospective study of 43 patients with ONFH-N and 43 participants without ONFH-N, enrolled from 10/2014 to 10/2016 at the Department of Orthopedics of the Linyi People's Hospital (China). The two groups were matched for age, gender, and living area. Microarray analysis and quantitative RT-PCR were used to examine the differentially expressed miRNAs. Bioinformatics was used to predict miRNA target genes and signaling pathways. Microarray and quantitative RT-PCR revealed that nine miRNAs were downregulated and five miRNAs were upregulated in ONFH-N (n = 3) compared with controls (n = 3). Bioinformatics showed that calcium-mediated signaling pathway, regulation of calcium ion transmembrane transporter activity, cytoskeletal protein binding, and caveolae macromolecular signaling complex were probably regulated by the identified differentially expressed miRNAs. In the remaining 80 subjects (n = 40/group), miR-335-5p was downregulated (P = 0.01) and miR-100-5p was upregulated (P = 0.02) in ONFH-N compared with controls. In conclusion, some miRNAs are differentially expressed in conservatively treated ONFH-N compared with controls. Those miRNAs could contribute to the pathogenesis of ONFH-N.

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Emerging roles of MicroRNAs in osteonecrosis of the femoral head

Abstract: Osteonecrosis of the femoral head (ONFH) is one of the most common orthopaedic diseases. The exact pathogenic mechanism of ONFH is still unknown. MicroRNAs

Cited by 45 publications

References 49 publications

microRNA‐148a‐3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head

microRNA‐148a‐3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head

AAV-Anti-miR-214 Prevents Collapse of the Femoral Head in Osteonecrosis by Regulating Osteoblast and Osteoclast Activities

Differentially Expressed MicroRNAs in Conservatively Treated Nontraumatic Osteonecrosis Compared with Healthy Controls

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