Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer’s Disease

Zhang, Guoxin; Peng, Qinyu; Huang, Liqin; Zhang, Zhaohui; Zhang, Zhentao

doi:10.3233/jad-221016

Cited by 13 publications

(10 citation statements)

References 116 publications

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“…How PBM can improve cognitive function remains poorly understood. Emerging evidence indicates the important roles of BDS in the resistant to neurocognitive disorders [ 8 , 9 , 14 , 63 – 68 ]. Indeed, dysfunction of MLVs results in less drainage of brain fluids to the cervical lymph nodes [ 8 , 11 , 12 , 19 , 28 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice

Semyachkina-Glushkovskaya,

Fedosov,

Zaikin

et al. 2023

Biomed. Opt. Express

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In this study on healthy male mice using confocal imaging of dye spreading in the brain and its further accumulation in the peripheral lymphatics, we demonstrate stronger effects of photobiomodulation (PBM) on the brain’s drainage system in sleeping vs. awake animals. Using the Pavlovian instrumental transfer probe and the 2-objects-location test, we found that the 10-day course of PBM during sleep vs. wakefulness promotes improved learning and spatial memory in mice. For the first time, we present the technology for PBM under electroencephalographic (EEG) control that incorporates modern state of the art facilities of optoelectronics and biopotential detection and that can be built of relatively cheap and commercially available components. These findings open a new niche in the development of smart technologies for phototherapy of brain diseases during sleep.

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Section: Discussionmentioning

confidence: 99%

Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice

Semyachkina-Glushkovskaya,

Fedosov,

Zaikin

et al. 2023

Biomed. Opt. Express

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“…Such disruption also results in cognitive impairment and behavioral alterations due to dysfunctions of the brain’s waste removal system leading to the accumulation of toxins and metabolites in the CNS 75 . The dysfunction of the MLVs might provide an important contribution to age-related cognitive decline and neuro-degenerative disease 76 , 77 . The MLVs also affect microglia responses 75 .…”

Section: Discussionmentioning

confidence: 99%

Transcranial photobiomodulation improves insulin therapy in diabetic microglial reactivity and the brain drainage system

Liu,

Li,

et al. 2023

Commun Biol

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The dysfunction of microglia in the development of diabetes is associated with various diabetic complications, while traditional insulin therapy is insufficient to rapidly restore the function of microglia. Therefore, the search for new alternative methods of treating diabetes-related dysfunction of microglia is urgently needed. Here, we evaluate the effects of transcranial photobiomodulation (tPBM) on microglial function in diabetic mice and investigate its mechanism. We find tPBM treatment effectively improves insulin therapy on microglial morphology and reactivity. We also show that tPBM stimulates brain drainage system through activation of meningeal lymphatics, which contributes to the removal of inflammatory factor, and increase of microglial purinergic receptor P2RY12. Besides, the energy expenditure and locomotor activity of diabetic mice are also improved by tPBM. Our results demonstrate that tPBM can be an efficient, non-invasive method for the treatment of microglial dysfunction caused by diabetes, and also has the potential to prevent diabetic physiological disorders.

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“…In MLVs specifically, such age-related dysfunctions reduce influx and outflux of CSF. It triggers the accumulation of metabolic products, accelerates neuroinflammation, induces the release of pro-inflammatory cytokines in the brain, and consequently aggravates cognitive dysfunction (Guo et al 2023 ).…”

Section: Age-related Alterations In Csf Outflow Pathwaysmentioning

confidence: 99%

The nasal lymphatic route of CSF outflow: implications for neurodegenerative disease diagnosis and monitoring

Chae,

Choi,

Choi

et al. 2024

Animal Cells and Systems

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Cerebrospinal fluid (CSF) plays a crucial role in the brain's lymphatics as it traverses the central nervous system (CNS). Its primary function is to facilitate the outward transport of waste. Among the various CSF outflow pathways, the route through the cribriform plate along the olfactory nerves stands out as the most predominant. This review describes the outflow pathway of CSF into the nasal lymphatics. Additionally, we examine existing studies to describe mutual influences observed between the brain and extracranial regions due to this outflow pathway. Notably, pathological conditions in the CNS often influence CSF outflow, leading to observable changes in extracranial regions. The established connection between the brain and the nose is significant, and our review underscores its potential relevance in monitoring CNS ailments, including neurodegenerative diseases. Considering that aging – the most significant risk factor for the onset of neurodegeneration – is also a principal factor in CSF turnover alterations, we suggest a novel approach to studying neurodegenerative diseases in therapeutic terms.

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Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer’s Disease

Cited by 13 publications

References 116 publications

Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice

Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice

Transcranial photobiomodulation improves insulin therapy in diabetic microglial reactivity and the brain drainage system

The nasal lymphatic route of CSF outflow: implications for neurodegenerative disease diagnosis and monitoring

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