Emerging roles of long noncoding RNAs in chemoresistance of pancreatic cancer

Xie, Wangkai; Chu, Maoping; Song, Gendi; Zuo, Ziyi; Zheng, Han; Chen, Chenbin; Li, Yuyun; Wang, Zhiwei

doi:10.1016/j.semcancer.2020.11.004

Cited by 87 publications

(72 citation statements)

References 261 publications

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“…Total expression of MEG3 was not statistically correlated to either histological grade or tumor node metastasis stage in the 25 cases of micro-dissected pancreatic cancer tissues (54), which we proposed was due to the unpurified cell they used. MEG3 is involved in modulating drug resistance to chemotherapy in multiple types of human cancers (52). During the preparation of this manuscript, a latest study selected MEG3 as the potential target gene by combination and reuse of several microarray datasets on PDAC and normal tissues and found decreased MEG3 in PDAC tissues (28).…”

Section: Discussionmentioning

confidence: 99%

“…This LincRNA gene, MEG3 , was closely involved in modulating drug resistance to chemotherapy in multiple types of human cancers including pancreatic cancer ( 52 ). Bulk levels of MEG3 expression were negatively correlated with PI3K expression and were closely correlated with tumor size, metastasis and vascular invasion in pancreatic cancer ( 53 ).…”

Section: Discussionmentioning

confidence: 99%

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A Cancer Cell Cluster Marked by LincRNA MEG3 Leads Pancreatic Ductal Adenocarcinoma Metastasis

et al. 2021

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Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence worldwide. Late detection and particularly aggressive characteristics are the major challenges that lead to therapeutic failure of this disease. A well described gene program and core regulators are yet to be discovered to drive the metastasis of the PDAC cells. As the development of single cell omics technologies including single cell RNA-sequencing (scRNA-seq), detailed characterization of the cellular composition of solid tumors and their microenvironments are well elaborated. In the current study, we accessed a recently published scRNA-seq dataset on primary and metastatic PDAC tissues and subset the tumor cells. By comparative analysis, we profiled the differentially expressed gene programs of primary and metastatic PDAC and found several long intergenic non-coding RNAs (LincRNAs) in top genes. The PDAC cancer cells showed some heterogeneity and were divided into four major subclusters based on gene profiles, one of which was mostly contributed by metastatic PDAC. Interestingly, this subcluster was remarkably marked by one of the above LincRNAs, MEG3, and exhibited significantly increased Epithelial–Mesenchymal-Transition (EMT) signatures. Ingenuity Pathway Analysis (IPA) on the signature genes of this subcluster gave multiple cancer metastasis associated and EMT signaling pathways, suggesting a critical role of this cluster in leading tumor cell metastasis. Taken together, this study displayed a PDAC cancer subcluster and its marker gene, biologically targeting of which might significantly attenuate the metastasis of tumor and might be a potential strategy for the therapeutic treatment of cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Cancer Cell Cluster Marked by LincRNA MEG3 Leads Pancreatic Ductal Adenocarcinoma Metastasis

et al. 2021

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“…Mitochondria have many fundamental functions such as energy production, providing the precursors for multiple macromolecules such as lipids and nucleotides, and aiding differentiation, apoptosis, and the cell cycle 31 – 34 . In cancer, the association of mitochondrial dysfunction and carcinogenesis is well established 35 – 39 , but whether TNT formation and associated mitochondrial transfer participate in tumor adaptation to the microenvironment is unknown. Overall, malignant brain tumors show metabolic abnormalities as reflected by increased uptake of glucose 40 and the use of unusual energy sources such as glutamate/glutamine that negatively correlate with GBM prognosis 41 , 42 .…”

Section: Introductionmentioning

confidence: 99%

Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions

Valdebenito

Malik

Luu

et al. 2021

Sci Rep

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Cell-to-cell communication is essential for the development and proper function of multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) proliferate in several pathological conditions such as HIV, cancer, and neurodegenerative diseases. However, the nature, function, and contribution of TNT to cancer pathogenesis are poorly understood. Our analyses demonstrate that TNT structures are induced between glioblastoma (GBM) cells and surrounding non-tumor astrocytes to transfer tumor-derived mitochondria. The mitochondrial transfer mediated by TNT resulted in the adaptation of non-tumor astrocytes to tumor-like metabolism and hypoxia conditions. In conclusion, TNT are an efficient cell-to-cell communication system used by cancer cells to adapt the microenvironment to the invasive nature of the tumor.

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“…Located at the chromosomal locus 7p15.2, lncRNA HOXA transcript at the distal tip (HOTTIP) has been found to be frequently abnormally expressed in various cancer types, containing gastric cancer [ 113 , 114 ], lung adenocarcinoma [ 115 ], head and neck squamous cell carcinoma [ 116 ], pancreatic cancer [ 117 , 118 ]. Importantly, HOTTIP was the first lncRNA documented to regulate Wnt expression in osteosarcoma.…”

Section: Regulatory Network Of Lncrnas and Wnt Signaling Pathway In Osteosarcomamentioning

confidence: 99%

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

Lin

Liu

et al. 2021

Cancer Cell Int

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Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or limited protein-coding capacity in human genomes, and have been demonstrated to play crucial functions in initiation, progression, therapeutic resistance, recurrence and metastasis of tumor. Considerable studies revealed a dysregulated lncRNA expression pattern in osteosarcoma, which may act as oncogenes or suppressors to regulate osteosarcoma progression. Wnt signaling pathway is an important cascade in tumorigenesis by modulation of pleiotropic biological functions including cell proliferation, apoptosis, differentiation, stemness, genetic stability and chemoresistance. Hyperactivation or deficiency of key effectors in Wnt cascade is a common event in many osteosarcoma patients. Recently, increasing evidences have suggested that lncRNAs could interplay with component of Wnt pathway, and thereby contribute to osteosarcoma onset, progression and dissemination. In this review, we briefly summarize Wnt signaling-related lncRNAs in osteosarcoma progression, aiming to gain insights into their underlying crosstalk as well as clinical application in osteosarcoma therapeutic modalities.

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Emerging roles of long noncoding RNAs in chemoresistance of pancreatic cancer

Cited by 87 publications

References 261 publications

A Cancer Cell Cluster Marked by LincRNA MEG3 Leads Pancreatic Ductal Adenocarcinoma Metastasis

A Cancer Cell Cluster Marked by LincRNA MEG3 Leads Pancreatic Ductal Adenocarcinoma Metastasis

Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

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