Emerging Roles of LncRNAs in the EZH2-regulated Oncogenic Network

Hao, Aixin; Wang, Yunxuan; Stovall, Daniel B.; Wang, Yu; Sui, Guangchao

doi:10.7150/ijbs.63488

Cited by 13 publications

(6 citation statements)

References 191 publications

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“…EZH2 overexpression seems to represent a critical event in the development of ATCs since the deregulated expression of several ncRNAs contributes to regulating the expression and functions of EZH2, as observed for miRNAs [88,124], circRNA [125], and additional lncRNAs [126]. Indeed, in ATC, there is a decrease in miR-25 and miR-30d levels, inversely correlated with the increased levels of EZH2.…”

Section: Ac0796302mentioning

confidence: 94%

Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Martino

Esposito

Capone

et al. 2022

Cancers

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Among the thyroid neoplasias originating from follicular cells, we can include well-differentiated carcinomas, papillary (PTC) and follicular (FTC) thyroid carcinomas, and the undifferentiated anaplastic (ATC) carcinomas. Several mutations in oncogenes and tumor suppressor genes have already been observed in these malignancies; however, we are still far from the comprehension of their full regulation-altered landscape. Even if only 2% of the human genome has the ability to code for proteins, most of the noncoding genome is transcribed, constituting the heterogeneous class of noncoding RNAs (ncRNAs), whose alterations are associated with the development of several human diseases, including cancer. Hence, many scientific efforts are currently focused on the elucidation of their biological role. In this review, we analyze the scientific literature regarding the involvement of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and pseudogenes in FTC, PTC, and ATC. Recent findings emphasized the role of lncRNAs in all steps of cancer progression. In particular, lncRNAs may control progression steps by regulating the expression of genes and miRNAs involved in cell proliferation, apoptosis, epithelial–mesenchymal transition, and metastatization. In conclusion, the determination of the diagnosis, prognosis, and treatment of cancer based on the evaluation of the ncRNA network could allow the implementation of a more personalized approach to fighting thyroid tumors.

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Section: Ac0796302mentioning

confidence: 94%

Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Martino

Esposito

Capone

et al. 2022

Cancers

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“…Enhancer of zeste homolog 2 (EZH2), a well-known protein with a SET domain ( Hao et al, 2021 ), is the key catalytic component of Polycomb repressive complex 2 (PRC2), which catalyzes the tri-methylation of lysine 27 on histone 3 (H3K27me3), a well-known marker of transcriptional repression ( Li et al, 2020 ). It has been demonstrated that LncRNA MEG3 inhibits chondrogenic differentiation of SMSCs via binding EZH2 and further regulating TRIB2.…”

Section: Regulation Of the Ecm By Lncrnas In Osteoarthritismentioning

confidence: 99%

“…As a HOTAIRM1-1 sponge, miR-125b regulates cell differentiation by targeting bone morphogenetic protein receptor 2 (BMPR2), thus reversing the inhibitory effects of HOTAIRM1-1 on the expression of type II collagen, aggrecan, and type X collagen (Xiao et al, 2019b). Enhancer of zeste homolog 2 (EZH2), a well-known protein with a SET domain (Hao et al, 2021), is the key catalytic component of Polycomb repressive complex 2 (PRC2), which catalyzes the trimethylation of lysine 27 on histone 3 (H3K27me3), a well-known marker of transcriptional repression (Li et al, 2020). It has been demonstrated that LncRNA MEG3 inhibits chondrogenic differentiation of SMSCs via binding EZH2 and further regulating TRIB2.…”

Section: Lncrnas Regulate Chondrogenic Differentiation and Ecm Dynamicsmentioning

confidence: 99%

Biological functions and applications of LncRNAs in the regulation of the extracellular matrix in osteoarthritis

Shi,

Mei,

Hao

et al. 2024

Front. Cell Dev. Biol.

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Osteoarthritis (OA) is a major cause of disability, characterized by chronic pain, irreversible destruction, and loss of function of the articular cartilage. The integrity and arrangement of the composition and structure of the extracellular matrix (ECM) are essential for maintaining the elasticity, integrity, and mechanical support function of the cartilage tissue. Osteoarthritis causes substantial changes in the ECM, driving the progression of the disease. Recent studies have shown that the ECM plays a critical role in the development of cartilage tissue as well as the occurrence and development of osteoarthritis by directly or indirectly regulating chondrocyte proliferation, apoptosis, differentiation, and gene expression. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs derived from large transcripts. Mutations and disorders of lncRNAs are closely related to the development of osteoarthritis. Abnormal expression of lncRNAs in osteoarthritic cartilage regulates the synthesis and decomposition of the cartilaginous ECM. Therefore, the use of lncRNAs as nucleic acid drugs that regulate their targets may reduce ECM degradation, thereby delaying the pathological progression of osteoarthritis. In this review, the regulatory effects of lncRNAs on ECM in different cell behaviors related to OA are summarized. The roles of lncRNAs in the proliferation, apoptosis, differentiation, and ECM-related gene activity of chondrocytes, as well as the application of lncRNAs as potential gene therapy drugs for the repair and regeneration of osteoarthritic tissue, are also reviewed. A better understanding of the roles of lncRNAs in guiding chondrocyte behavior and ECM metabolism is critical for their future applications in osteoarthritis therapy and regenerative medicine.

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“…Alternatively, EZH2 may be a context‐dependent regulator for ciliation, with positive regulation in BCC but negative regulation in other cancers for ciliation. Of course, the cilia‐uncorrelated function of EZH2 (Hao et al, 2021; Li & Chng, 2019; Wen et al, 2021) may override its cilia‐related function in tumors. The above‐mentioned hypotheses need further investigation.…”

Section: Primary Cilia and Cancermentioning

confidence: 99%

Primary cilia: Structure, dynamics, and roles in cancer cells and tumor microenvironment

Guan

Zhang

et al. 2023

Journal Cellular Physiology

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Despite the initiation of tumor arises from tumorigenic transformation signaling in cancer cells, cancer cell survival, invasion, and metastasis also require a dynamic and reciprocal association with extracellular signaling from tumor microenvironment (TME). Primary cilia are the antenna‐like structure that mediate signaling sensation and transduction in different tissues and cells. Recent studies have started to uncover that the heterogeneous ciliation in cancer cells and cells from the TME in tumor growth impels asymmetric paracellular signaling in the TME, indicating the essential functions of primary cilia in homeostasis maintenance of both cancer cells and the TME. In this review, we discussed recent advances in the structure and assembly of primary cilia, and the role of primary cilia in tumor and TME formation, as well as the therapeutic potentials that target ciliary dynamics and signaling from the cells in different tumors and the TME.

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Emerging Roles of LncRNAs in the EZH2-regulated Oncogenic Network

Cited by 13 publications

References 191 publications

Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Biological functions and applications of LncRNAs in the regulation of the extracellular matrix in osteoarthritis

Primary cilia: Structure, dynamics, and roles in cancer cells and tumor microenvironment

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