Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes

Wen, Xianjie; Yang, Ying

doi:10.1530/jme-16-0232

Cited by 45 publications

(24 citation statements)

References 75 publications

(105 reference statements)

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“…KLF4 is mainly engaged in the regulation of normal placentation and apoptosis (Blanchon et al 2001 ; Rowland et al 2005 ) while GLIS3 is implicated in the development of some fetal organs, such as the pancreas or thyroid (Dimitri 2017 ; Dimitri et al 2011 ; Nogueira et al 2013 ). Some case studies indicate that patients with a GLIS3 gene mutation resulting in a truncated non-functional protein demonstrated IUGR (Dimitri et al 2011 ).In addition, patients with disturbances in the GLIS3 gene demonstrate impaired beta cell function and an altered fasting glucose and diabetes mellitus phenotype (Wen and Yang 2017 ; Yang et al 2013 ). Further functional studies are needed to establish why the GLIS3 gene is depleted in the placentas of SGA (IUGR) fetuses developing in a limited energy environment.…”

Section: Discussionmentioning

confidence: 99%

Identification of placental genes linked to selective intrauterine growth restriction (IUGR) in dichorionic twin pregnancies: gene expression profiling study

et al. 2019

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A linkage of dichorionic (DC) twin pregnancies with selective intrauterine growth restriction (IUGR) to alterations in placental gene expression is unclear. The aim of the study was to identify placental genes related to hypoxia, adipogenesis and human growth which may contribute to IUGR development. The study group (IUGR/AGA) comprised dichorionic (DC) twin pregnancies, where the weight of the twins differed by > 15%; in addition, one twin was small for gestational age (< 10th percentile-SGA) (IUGR) while the other was appropriate for gestational age (> 10th percentile-AGA). In the control group (AGA/AGA), both fetuses were AGA and their weights differed by < 15%. In the first step (selection), placental expression of 260 genes was analysed by commercial PCR profiler array or qPCR primer assay between six pairs of IUGR/AGA twins. In the second stage (verification), the expression of 20 genes with fold change (FC) > 1.5 selected from the first stage was investigated for 75 DC pregnancies: 23 IUGR/AGA vs. 52 AGA/AGA. The expression of Angiopoetin 2, Leptin and Kruppel-like factor 4 was significantly higher, and Glis Family Zinc Finger 3 was lower, in placentas of SGA fetuses (FC = 3.3; 4.4; 1.6; and − 1.8, respectively; p < 0.05). The dysregulation of gene expression related to angiogenesis and growth factors in placentas of twins born from IUGR/AGA pregnancies suggest that these alternations might represent biological fetal adaptation to the uteral condition. Moreover, DC twin pregnancies may be a good model to identify the differences in placental gene expression between SGA and AGA fetuses.

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Section: Discussionmentioning

confidence: 99%

Identification of placental genes linked to selective intrauterine growth restriction (IUGR) in dichorionic twin pregnancies: gene expression profiling study

et al. 2019

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“…Another key molecule that could be linking thyroid and pancreas is transcription factor Gli-similar 3 (GLIS3). Variations of GLIS3 are strongly associated with both type 1 and type 2 diabetes in some populations [ 93 ]. GLIS3 can also coordinate with pancreatic and duodenal homeobox 1 (PDX1), MAFA, and neurogenic differentiation factor 1 (an insulin synthesis-related transcription factor) to potently regulate insulin gene transcription.…”

Section: Roles Of Thyroid and Thyroid Hormone In Pancreas Pathogenmentioning

confidence: 99%

The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology

Chen

Xie

Shen

et al. 2018

International Journal of Endocrinology

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It is widely accepted that thyroid hormones (THs), secreted from the thyroid, play important roles in energy metabolism. It is also known that THs also alter the functioning of other endocrine glands; however, their effects on pancreatic function have not yet been reviewed. One of the main functions of the pancreas is insulin secretion, which is altered in diabetes. Diabetes, therefore, could be related to thyroid dysfunction. Earlier research on this subject focused on TH regulation of pancreas function (such as insulin secretion) or on insulin function through TH-mediated increase of energy metabolism. Afterwards, epidemiological investigations and animal test research found a link between autoimmune diseases, thyroid dysfunction, and pancreas pathology; however, the underlying mechanisms remain unknown. Furthermore, recent studies have shown that THs also play important roles in pancreas development and on islet pathology, both in diabetes and in pancreatic cancer. Therefore, an overview of the effects of thyroid and THs on pancreas physiology and pathology is presented. The topics contained in this review include a summary of the relationship between autoimmune thyroid dysfunction and autoimmune pancreas lesions and the effects of THs on pancreas development and pancreas pathology (diabetes and pancreatic cancer).

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“…GLIS3, a member of the Glis subfamily of Krüppel-like zinc-finger transcription factors, was characterized as modulating a set of essential cellular functions, such as insulin production, β-cell maintenance and maturation, stem and progenitor cell differentiation, and development. 40 , 41 Although studies converge on GLIS3 functioning in cancer, diabetes, hypothyroidism, and polycystic kidney disease, 40 , 42 , 43 , 44 the exact role of GLIS3 in human OA is unknown, and the miRNA regulating the expression of GLIS3 remains unclear. In this study, we demonstrated that GLIS3 was a direct target of miR-106a-5p.…”

Section: Discussionmentioning

confidence: 99%

Cryptotanshinone Protects Cartilage against Developing Osteoarthritis through the miR-106a-5p/GLIS3 Axis

Xu³

et al. 2018

Molecular Therapy - Nucleic Acids

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Cryptotanshinone (CTS) has emerged as an anti-inflammatory agent in osteoarthritis (OA). However, the molecular mechanism underlying its potent therapeutic effect on OA remains largely unknown. MicroRNAs (miRNAs) act as crucial regulators in maintaining cartilage homeostasis. To investigate whether CTS protects against developing OA through regulation of miRNAs, we examined the potential CTS-mediated miRNA molecules using microarray analysis. We found that CTS significantly promoted miR-106a-5p expression in chondrocytes. Using the OA mouse model created by anterior cruciate ligament transection, we revealed that intra-articular injection of miR-106a-5p agomir attenuated OA. In addition, miR-106a-5p inhibited GLI-similar 3 (GLIS3) production by directly targeting the 3′ untranslated region. CTS promoted miR-106a-5p expression through recruitment of a member of the paired box (PAX) family of transcription factors, PAX5, to the miR-106a-5p promoter. Inhibition of PAX5 mimicked the effect of miR-106a-5p and abolished the CTS ability to regulate miR-106a-5p expression. In OA patients, miR-106-5p is downregulated which is accompanied by downregulation of PAX5 and upregulation of GLIS3. Collectively, these data highlight that the PAX5/miR-106a-5p/GLIS3 axis acts as a novel pleiotropic regulator in CTS-mediated OA cartilage protection, suggesting that miR-106a-5p and PAX5 activation and GLIS3 inhibition might be useful and attractive for therapeutic strategies to treat OA patients.

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Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes

Cited by 45 publications

References 75 publications

Identification of placental genes linked to selective intrauterine growth restriction (IUGR) in dichorionic twin pregnancies: gene expression profiling study

Identification of placental genes linked to selective intrauterine growth restriction (IUGR) in dichorionic twin pregnancies: gene expression profiling study

The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology

Cryptotanshinone Protects Cartilage against Developing Osteoarthritis through the miR-106a-5p/GLIS3 Axis

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