2013
DOI: 10.3402/jev.v2i0.20304
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Emerging roles of extracellular vesicles in the adaptive response of tumour cells to microenvironmental stress

Abstract: Cells are constantly subjected to various types of endogenous and exogenous stressful stimuli, which can cause serious and even permanent damage. The ability of a cell to sense and adapt to environmental alterations is thus vital to maintain tissue homeostasis during development and adult life. Here, we review some of the major phenotypic characteristics of the hostile tumour microenvironment and the emerging roles of extracellular vesicles in these events.

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Cited by 150 publications
(118 citation statements)
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References 105 publications
(147 reference statements)
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“…Exosomes/EVs have been described as a means of communication between tumor cells and other cell types, including those of the microenvironment and beyond, in breast, as well as other cancer types (11 ). Dysregulation in this cell-to-cell communication and thus undesirable cellular cross-talk is understood to contribute to cancer development and progression.…”
Section: Exosomes and Breast Cancermentioning
confidence: 99%
“…Exosomes/EVs have been described as a means of communication between tumor cells and other cell types, including those of the microenvironment and beyond, in breast, as well as other cancer types (11 ). Dysregulation in this cell-to-cell communication and thus undesirable cellular cross-talk is understood to contribute to cancer development and progression.…”
Section: Exosomes and Breast Cancermentioning
confidence: 99%
“…Under physiological conditions, for instance, secreted exosomes can transfer molecules between dendritic cells and B cells to mediate adaptive immune responses to pathogens. Under pathological conditions, such as in a tumor microenvironment, malignant cells, vascular cells, stromal cells, and immune cells surrounded by extracellular matrices (ECMs) and soluble factors use the cargo within secreted exosomes to engage in cell-to-cell communication to support tumor progression and metastasis (7). The identification of PRAS40 as a pivotal regulator of exosome secretion will hopefully lead to new insights about how microenvironmental and intracellular stress induces cells to secrete exosomes.…”
Section: Discussionmentioning
confidence: 99%
“…Rather, they secrete exosomes only under environmental stress cues. In contrast to normal cells, many tumor cells constitutively secrete exosomes driven by their intrinsic oncogenic signals (7,35). It would be of a great interest to test whether PRAS40 has any relationship with TSAP6 or Rab27.…”
Section: Discussionmentioning
confidence: 99%
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