Emerging roles of exosomal miRNAs in diabetes mellitus

He, Xiaoyun; Kuang, Gaoyan; Wu, Yongrong; Ou, Chunlin

doi:10.1002/ctm2.468

Cited by 120 publications

(89 citation statements)

References 188 publications

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“…In 1987, Johnstone et al defined and named these small vesicles with membranebased structure as exosomes (9). Exosomes are a type of extracellular vesicles (EVs) that exist in almost all kinds of body fluids, e.g., saliva, urine, and amniotic fluid (10)(11)(12). These EVs, including exosomes, were once considered cell waste products, but several studies have revealed that they can carry various cellular gene products, such as proteins, and a series of metabolites, which can be transferred to recipient cells (13).…”

Section: Introductionmentioning

confidence: 99%

Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis

et al. 2022

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Cancer-associated fibroblasts (CAFs) are the most important component of the stromal cell population in the tumor microenvironment and play an irreplaceable role in oncogenesis and cancer progression. Exosomes, a class of small extracellular vesicles, can transfer biological information (e.g., proteins, nucleic acids, and metabolites as messengers) from secreting cells to target recipient cells, thereby affecting the progression of human diseases, including cancers. Recent studies revealed that CAF-derived exosomes play a crucial part in tumorigenesis, tumor cell proliferation, metastasis, drug resistance, and the immune response. Moreover, aberrant expression of CAF-derived exosomal noncoding RNAs and proteins strongly correlates with clinical pathological characterizations of cancer patients. Gaining deeper insight into the participation of CAF-derived exosomes in tumorigenesis may lead to novel diagnostic biomarkers and therapeutic targets in human cancers.

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Section: Introductionmentioning

confidence: 99%

Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis

et al. 2022

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“…Traditional methods of vesicle extraction and isolation are limited to in their ability to isolate different subtypes of EVs. Therefore, the terms “EV,” “sEV,” and “exosome” are used interchangeably in some studies (He et al, 2021b ). This review focused on the function of exosomes.…”

Section: Introductionmentioning

confidence: 99%

“…Compared to traditional therapeutic drugs, exosomes carrying drugs are more likely to pass through the blood-brain barrier (BBB), which helps the drugs to reach the target tissue (Azarmi et al, 2020 ). Due to the prevalence and easy availability of exosomes in the organism, as well as their involvement in various biomodulatory effects, exosomes have been considered as potential biomarker candidates for the clinical diagnosis and prognosis of diseases (He et al, 2021b ). Over recent years, an increasing number of studies have explored the specific mechanisms of exosome involvement in brain disease (Soares Martins et al, 2021b ).…”

Section: Introductionmentioning

confidence: 99%

Role of Exosomes in Brain Diseases

Zhang

Chen

et al. 2021

Front. Cell. Neurosci.

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Exosomes are a subset of extracellular vesicles that act as messengers to facilitate communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are delivered by the exosomes to target molecules (such as proteins, mRNAs, or DNA) of host cells, thereby playing a key role in the maintenance of normal brain function. However, exosomes are also involved in the occurrence, prognosis, and clinical treatment of brain diseases, such as Alzheimer's disease, Parkinson's disease, stroke, and traumatic brain injury. In this review, we have summarized novel findings that elucidate the role of exosomes in the occurrence, prognosis, and treatment of brain diseases.

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“…Exosomes are extracellular vesicles that originate from the multivesicular bodies (MVBs) and are present in intercellular space or circulate in biological fluids ( Kalluri, 2016 ; Zhang and Yu, 2019 ; He et al, 2021a ). These vesicles can be internalized by neighboring cells or by remote receptor cells through fusion with the target cell membrane, thereby altering the behavior of the target cell ( Hessvik and Llorente, 2018 ; Gonda et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Exosomal circRNAs: Emerging Players in Tumor Metastasis

Zhou

et al. 2021

Front. Cell Dev. Biol.

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Metastasis is an important feature of malignant tumors, and is the primary cause of poor prognosis and treatment failure, in addition to representing a potentially fatal challenge for cancer patients. Exosomes are small extracellular vesicles 30–150 nm in diameter that transmit cargo, such as DNA, RNA, and proteins, as a means of intercellular communication. Exosomes play crucial roles in a range of human diseases, especially malignant tumors. A growing number of studies have verified that circRNAs can be enveloped in exosomes and transferred from secretory cells to recipient cells, thereby regulating tumor progression, especially tumor metastasis. Exosomal circRNAs regulate tumor cell metastasis not only by regulating the signaling pathways, but also by affecting the tumor microenvironment. Moreover, exosomal circRNAs have the potential to serve as valuable diagnostic biomarkers and novel therapeutic targets in cancer patients. In this review, we summarize the mechanism by which exosomal circRNAs modulate metastatic phenomena in various types of tumors, and put forward the prospects of clinical applications of exosomal circRNAs in tumor therapy.

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Emerging roles of exosomal miRNAs in diabetes mellitus

Cited by 120 publications

References 188 publications

Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis

Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis

Role of Exosomes in Brain Diseases

Exosomal circRNAs: Emerging Players in Tumor Metastasis

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