Emerging roles of circular RNAs in stem cells

Wang, Mengru; Wu, Juan; Wu, Pan; Li, Yuhong

doi:10.1016/j.gendis.2022.05.015

Cited by 4 publications

(4 citation statements)

References 145 publications

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“…circRNAs are non-coding RNAs that regulate a wide range of cellular processes such as gene transcription, RNA splicing, and miRNA sponging, 96 , 97 and their aberrant expression contributes to cancer, including HCC. 98 Cancer-promoting circRNAs are up-regulated in HCCs, whereas the expression of circRNAs with tumor-suppressing activity is usually reduced in HCCs.…”

Section: Non-coding Rnas Affecting Wnt/β-catenin Signaling In Hccmentioning

confidence: 99%

WNT/β-catenin signaling in hepatocellular carcinoma: The aberrant activation, pathogenic roles, and therapeutic opportunities

Gajos-Michniewicz¹,

Czyż²

2024

Genes & Diseases

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Section: Non-coding Rnas Affecting Wnt/β-catenin Signaling In Hccmentioning

confidence: 99%

WNT/β-catenin signaling in hepatocellular carcinoma: The aberrant activation, pathogenic roles, and therapeutic opportunities

Gajos-Michniewicz¹,

Czyż²

2024

Genes & Diseases

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“…Previous studies revealed that ncRNAs such as miRNAs, lncRNAs, and cirRNAs play essential roles in stimulating or suppressing pathogenesis in LSCs. 221 , 222 , 223 , 224 It has been demonstrated that various lncRNAs, including HOXA10-AS, DANCR, HOTAIR, LAMP5-AS1, Morrbid, LINC00152, HOTTIP, MAGI2-AS3, and KIAA0125 participated in the survival, proliferation, and differentiation of LSCs. Besides, some studies have explored the effects of multiple cirRNAs such as circ_0040,823, circ_0004277, circCRKL, circ_0005774, and Hsa-circ_0003420 in LSCs' properties.…”

Section: Signaling Pathways Governing Lsc Maintenancementioning

confidence: 99%

Signaling pathways governing the behaviors of leukemia stem cells

Azizidoost¹,

Nasrolahi²,

Sheykhi-Sabzehpoush³

et al. 2024

Genes & Diseases

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“…Gu et al [ 68 ] identified 1382 circRNAs that could bind with 148 common miRNAs and also predicted these miRNAs to regulate the pluripotency of PDLSCs. It has also been shown that, during PDLSC osteogenic differentiation, circRNA expression is stage specific [ 69 ].…”

Section: Circrnas In Periodontal Ligament Stem Cells and Periodontal ...mentioning

confidence: 99%

Circular RNA-Mediated Regulation of Oral Tissue-Derived Stem Cell Differentiation: Implications for Oral Medicine and Orthodontic Applications

Suciu,

Feștilă,

Berindan-Neagoe

et al. 2024

Stem Cell Rev and Rep

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Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs (ncRNAs) which unlike linear RNAs, have a covalently closed continuous loop structure. circRNAs are found abundantly in human cells and their biology is complex. They feature unique expression to different types of cells, tissues, and developmental stages. To the present, the functional roles of circular RNAs are not fully understood. They reportedly act as microRNA (miRNA) sponges, therefore having key regulatory functions in diverse physiological and pathological processes. As for dentistry field, lines of evidence indicate that circRNAs play vital roles in the odontogenic and osteogenic differentiation of dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs). Abnormal expression of circRNAs have been found in other areas of pathology frequently reflected also in the oral environment, such as inflammation or bone and soft tissue loss. Therefore, circRNAs could be of significant importance in various fields in dentistry, especially in bone and soft tissue engineering and regeneration. Understanding the molecular mechanisms occurring during the regulation of oral biological and tissue remodeling processes could augment the discovery of novel diagnostic biomarkers and therapeutic strategies that will improve orthodontic and other oral therapeutic protocols. Graphical Abstract

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Emerging roles of circular RNAs in stem cells

Cited by 4 publications

References 145 publications

WNT/β-catenin signaling in hepatocellular carcinoma: The aberrant activation, pathogenic roles, and therapeutic opportunities

WNT/β-catenin signaling in hepatocellular carcinoma: The aberrant activation, pathogenic roles, and therapeutic opportunities

Signaling pathways governing the behaviors of leukemia stem cells

Circular RNA-Mediated Regulation of Oral Tissue-Derived Stem Cell Differentiation: Implications for Oral Medicine and Orthodontic Applications

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