Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer

Luo, Yanhong; Zhu, Xiaozhong; Huang, Kaijun; Zhang, Qian; Fan, Yanxin; Yan, Pengwei; Wen, Jing

doi:10.1016/j.biopha.2017.12.015

Cited by 106 publications

(61 citation statements)

References 33 publications

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“…Recent studies indicated that circRNAs play key roles in lung cancer progression. For example, Luo et al showed that hsa_circ_0 0 0 0 064 was upregulated in lung cancer and promoted tumor proliferation and invasion ability [17] . Qiu et al suggested that circRNA FGFR3 promoted NSCLC progression through the Galectin-1-AKT/ERK1/2 axis [18] .…”

Section: Discussionmentioning

confidence: 99%

hsa_circ_0062389 promotes the progression of non-small cell lung cancer by sponging miR-103a-3p to mediate CCNE1 expression

et al. 2020

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hsa_circ_0062389 miR-103a-3p CCNE1 Non-small cell lung cancer a b s t r a c tRecently, increasing evidence showed that circular RNAs (circRNAs) play critical roles in tumor progression. However, the roles of hsa_circ_0062389 in non-small cell lung cancer (NSCLC) development remain unclear. In the present study, hsa_circ_0062389 expression was significantly increased in NSCLC tissues and cell lines. High hsa_circ_0062389 expression was associated with advanced TNM stage and lymphnode metastasis. Function assays showed that hsa_circ_0062389 suppression reduced NSCLC cells proliferation and arrested cell cycle in G0/G1 phase. In mechanism, hsa_circ_0062389 directly interacted with miR-103a-3p in NSCLC, and CCNE1 acted as a target of miR-103a-3p. Furthermore, rescue assays showed that miR-103a-3p suppression or CCNE1 overexpression abolished the effects of hsa_circ_0062389 suppression on lung cancer cells progression. Therefore, our results showed that the hsa_circ_0062389/miR-103a-3p/CCNE1 axis might contribute to the tumorigenesis of NSCLC, which provided a new strategy for cancer treatment.

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Section: Discussionmentioning

confidence: 99%

hsa_circ_0062389 promotes the progression of non-small cell lung cancer by sponging miR-103a-3p to mediate CCNE1 expression

et al. 2020

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“…[25][26][27][28] A number of studies have reported that circRNAs play a critical role in many diseases, [8][9][10][11] including cancers. [12][13][14][15] However, the functions of circRNAs in CRC are unclear. In the present study, we found that circHUWE1 was upregulated in CRC tissues and this was consistent with our previous research on high-throughput sequencing and bioinformatics analyses.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7] Based on the above functions of circRNAs above, a number of studies have revealed that circRNAs correlate with diverse diseases, [8][9][10][11] including cancers. [12][13][14][15] Thus, circRNAs hold the potential to function as therapeutic targets and diagnostic biomarkers of cancers. However, little is known regarding to the functions of circRNAs in CRC.…”

Section: Introductionmentioning

confidence: 99%

<p>Circular RNA circHUWE1 Is Upregulated and Promotes Cell Proliferation, Migration and Invasion in Colorectal Cancer by Sponging miR-486</p>

Chen

et al. 2020

OTT

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Background: Emerging studies have revealed that circular RNAs (circRNAs) correlate with diverse diseases including cancers. However, little is known about the functions of circRNAs in colorectal cancer (CRC). In our previous research, downregulation of hsa_circ_0140388 (circHUEW1) has been detected in CRC tissues through highthroughput sequencing. However, the underlying mechanism by which circHUWE1 regulates the proliferation and apoptosis in CRC has not been investigated. Materials and Methods: The levels of circHUWE1 in 58 pairs of CRC tissues and corresponding adjacent healthy tissues were detected by RT-qPCR. In addition, the effects of circHUWE1 on cell proliferation, apoptosis migration and invasion were evaluated by cell proliferation assays, flow cytometry, and transwell assays in HCT116 and SW480 cell lines respectively. Meanwhile, the dual-luciferase reporter system assay was used to explore the interaction between circHUWE1 and miR-486 (hsa-miR-486-5p). Results: In this study, we demonstrate that the expression of circHUEW1 is upregulated in CRC tissues. High expression of circHUEW1 was significantly associated with lymphovascular invasion (P =0.036), lymph node metastasis (P =0.017), distant metastasis (P =0.024), and TNM stage (P =0.009). Moreover, the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was 0.732, which indicated that circHUWE1 could serve as a potential biomarker in the detection of CRC. Silencing circHUWE1 significantly inhibited the proliferation, migration and invasion capacity of CRC cells in vitro. Mechanistically, we demonstrated that circHUWE1 could sponge miR-486 and the downregulation of miR-486 could reverse the cancer suppressive effects caused by silencing circHUWE1. Conclusion: In this study, our results revealed that circHUWE1 may be a potential therapeutic target and diagnostic biomarker for CRC.

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“…circRNA_100290 is markedly upregulated in oral squamous cell carcinoma tissue, and the knockdown of circRNA_100290 significantly inhibits the proliferative ability of cells (22). In lung cancer, interference of upregulated hsa_circ_0000064 markedly blocked cell cycle progression, promoted cell apoptosis, and decreased migration and invasive activities (23). Therefore, hsa_circ_0033155 was overexpressed in NSCLC cells with lower levels of the circRNA to detect whether the biological functions were attenuated.…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer

Wang

Shen

et al. 2018

Exp Ther Med

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Circular RNAs (circRNAs) are a novel type of endogenous RNAs and increasing evidence have uncovered the important role of circRNA in tumor progression; however, the function of circRNAs in non-small cell lung cancer (NSCLC) remains largely unclear. In the present study, it was demonstrated that the expression level of hsa_circ_0033155 was significantly downregulated in NSCLC tissue and the expression of hsa_circ_0033155 correlated with lymphatic metastasis. In order to further investigate the possible role of hsa_circ_0033155 in NSCLC progression, circRNA was overexpressed in NSCLC cells and it was observed that the overexpression of hsa_circ_0033155 significantly decreased cell proliferation, colony formation and migration, and elevated the level of phosphatase and tensin homolog deleted on chromosome 10, a tumor suppressor in many types of tumor. In conclusion, hsa_circ_0033155 may serve as a prospective biomarker for detection and a promising therapeutic target for NSCLC.

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Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer

Cited by 106 publications

References 33 publications

hsa_circ_0062389 promotes the progression of non-small cell lung cancer by sponging miR-103a-3p to mediate CCNE1 expression

hsa_circ_0062389 promotes the progression of non-small cell lung cancer by sponging miR-103a-3p to mediate CCNE1 expression

<p>Circular RNA circHUWE1 Is Upregulated and Promotes Cell Proliferation, Migration and Invasion in Colorectal Cancer by Sponging miR-486</p>

Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer

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