Emerging roles of CCN proteins in vascular development and pathology

Klenotic, Philip A.; Zhang, Chao; Lin, Zhiyong

doi:10.1007/s12079-016-0332-z

Cited by 21 publications

(15 citation statements)

References 79 publications

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“…These proteins have been shown to be reservoirs of growth factors and to promote intracellular signaling. This occurs through the interaction with cell surface integrins, receptors, or other ECM molecules [232]. These molecules have been extensively studied and their role in the modulation of the proliferation, migration and adhesion of EC, among other cells, established.…”

Section: The Ccn Family Of Proteins As Regulators Of Vascular Devementioning

confidence: 99%

Extracellular Matrix, a Hard Player in Angiogenesis

Mongiat

Andreuzzi

Tarticchio

et al. 2016

IJMS

166

133

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The extracellular matrix (ECM) is a complex network of proteins, glycoproteins, proteoglycans, and polysaccharides. Through multiple interactions with each other and the cell surface receptors, not only the ECM determines the physical and mechanical properties of the tissues, but also profoundly influences cell behavior and many physiological and pathological processes. One of the functions that have been extensively explored is its impingement on angiogenesis. The strong impact of the ECM in this context is both direct and indirect by virtue of its ability to interact and/or store several growth factors and cytokines. The aim of this review is to provide some examples of the complex molecular mechanisms that are elicited by these molecules in promoting or weakening the angiogenic processes. The scenario is intricate, since matrix remodeling often generates fragments displaying opposite effects compared to those exerted by the whole molecules. Thus, the balance will tilt towards angiogenesis or angiostasis depending on the relative expression of pro- or anti-angiogenetic molecules/fragments composing the matrix of a given tissue. One of the vital aspects of this field of research is that, for its endogenous nature, the ECM can be viewed as a reservoir to draw from for the development of new more efficacious therapies to treat angiogenesis-dependent pathologies.

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Section: The Ccn Family Of Proteins As Regulators Of Vascular Devementioning

confidence: 99%

Extracellular Matrix, a Hard Player in Angiogenesis

Mongiat

Andreuzzi

Tarticchio

et al. 2016

IJMS

166

133

View full text Add to dashboard Cite

show abstract

“…Ethical approval. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5). Informed consent was obtained from all patients for being included in the study.…”

Section: Discussionmentioning

confidence: 99%

Expression of Cyr61 in ApoE−/− mice with chronic unilateral renal artery ligation

Pathak

Rojas

Stouffer

2021

Sci Rep

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Cyr61 is a member of the CCN family of proteins that is expressed in atherosclerotic lesions and regulated by angiotensin II. It is unknown whether renal artery stenosis (RAS) increases Cyr61 expression. Male ApoE−/− mice were randomized to surgically induced RAS, RAS + treatment with either irbesartan, aliskiren or amlodipine or sham-surgery. RAS resulted in increased plasma angiotensin II levels, a mild, sustained increase in systolic blood pressure and increased aortic lipid deposition compared to sham-surgery. Surgically induced RAS led to the formation of atheroma in the infrarenal aorta and there was consistent and intense staining for Cyr61 within the atheroma. Treatment with irbesartan, aliskiren and amlodipine were associated with decreased aortic lipid deposition and decreased staining for Cyr61 in aortic atheroma. Serum levels of Cyr61 were not increased in mice or humans with RAS. In summary, Cyr61 expression in aortic atheroma but not serum is increased by RAS in ApoE−/− mice and is reduced by agents that lower blood pressure.

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“…Importantly, vascular smooth muscle cells represent a distinct and terminally differentiated cell, and lack the multipotentiality of PSC. WISP-1 has also been implicated in the promotion of angiogenesis, especially in tumor associated angiogenesis 22 – 24 . In the current study, we found enrichment of WISP-1 within PSC both in situ , after purification, and after in vivo application in a bone defect microenvironment.…”

Section: Discussionmentioning

confidence: 99%

WISP-1 drives bone formation at the expense of fat formation in human perivascular stem cells

Meyers

Asatrian

et al. 2018

Sci Rep

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The vascular wall within adipose tissue is a source of mesenchymal progenitors, referred to as perivascular stem/stromal cells (PSC). PSC are isolated via fluorescence activated cell sorting (FACS), and defined as a bipartite population of pericytes and adventitial progenitor cells (APCs). Those factors that promote the differentiation of PSC into bone or fat cell types are not well understood. Here, we observed high expression of WISP-1 among human PSC in vivo, after purification, and upon transplantation in a bone defect. Next, modulation of WISP-1 expression was performed, using WISP-1 overexpression, WISP-1 protein, or WISP-1 siRNA. Results demonstrated that WISP-1 is expressed in the perivascular niche, and high expression is maintained after purification of PSC, and upon transplantation in a bone microenvironment. In vitro studies demonstrate that WISP-1 has pro-osteogenic/anti-adipocytic effects in human PSC, and that regulation of BMP signaling activity may underlie these effects. In summary, our results demonstrate the importance of the matricellular protein WISP-1 in regulation of the differentiation of human stem cell types within the perivascular niche. WISP-1 signaling upregulation may be of future benefit in cell therapy mediated bone tissue engineering, for the healing of bone defects or other orthopaedic applications.

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Emerging roles of CCN proteins in vascular development and pathology

Cited by 21 publications

References 79 publications

Extracellular Matrix, a Hard Player in Angiogenesis

Extracellular Matrix, a Hard Player in Angiogenesis

Expression of Cyr61 in ApoE−/− mice with chronic unilateral renal artery ligation

WISP-1 drives bone formation at the expense of fat formation in human perivascular stem cells

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