Emerging roles of bioactive peptides on brain health promotion

Katayama, Shigeru; Nakamura, Soichiro

doi:10.1111/ijfs.14076

Cited by 19 publications

(10 citation statements)

References 65 publications

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“…Protein hydrolysates or bioactive peptides generated from food proteins have been identified with various health-promoting properties, such as anti-oxidative, antibacterial, anti-cancer, anti-inflammatory, anti-hypertensive, immuno-regulatory, and other activities [ 33 , 34 ]. Furthermore, due to their potential neuroprotective and brain health effects, bioactive peptides have been suggested as a way to prevent cognitive decline and dementia [ 35 ]. More importantly, protein hydrolysates and bioactive peptides can be chemically modified to change their properties.…”

Section: Discussionmentioning

confidence: 99%

Impact of the Plastein Reaction of Casein Hydrolysates in the Presence of Exogenous Amino Acids on Their Anti-Inflammatory Effect in the Lipopolysaccharide-Stimulated Macrophages

Shi

Zhao

2022

Foods

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In this study, papain-generated casein hydrolysates (CH) with a degree of hydrolysis of 13.7% were subjected to a papain-mediated plastein reaction in the absence or presence of one of the exogenous amino acids—Gly, Pro, and Hyp—to prepare four plastein modifiers, or mixed with one of three amino acids to prepare three mixtures. The assay results confirmed that the reaction reduced free NH2 for the modifiers and caused amino acid incorporation and peptide condensation. When RAW264.7 macrophages were exposed to the CH, modifiers, and mixtures, these samples promoted macrophage growth and phagocytosis in a dose-dependent manner. In addition, the CH shared similar activity in the cells as the mixtures, while the modifiers (especially the PCH-Hyp prepared with Hyp addition) exerted higher potential than CH, the mixtures, and PCH (the modifier prepared without amino acid addition). The plastein reaction thus enhanced CH bioactivity in the cells. When RAW264.7 macrophages were stimulated with lipopolysaccharide (LPS), the inflammatory cells produced more lactate dehydrogenase (LDH) release and reactive oxygen species (ROS) formation, and caused more four inflammatory mediators (NO, PGE2, TNF-α, and IL-6) and two anti-inflammatory mediators (TGF-β1 and IL-10). However, the PCH-Hyp, PCH, and CH at dose levels of 100 μg/mL could combat against the LPS-induced inflammation. Overall, the PCH-Hyp was more active than the CH and PCH in reducing LDH release, ROS formation, and the secretion of these inflammatory mediators, or in increasing the secretion of the anti-inflammatory mediators. The qPCR and Western blot analysis results further confirmed that these samples had anti-inflammatory effects on the stimulated cells by suppressing the LPS-induced activation of the NF-κB signaling pathway, via regulating the mRNA/miRNA expression of iNOS, IL-6, TNF-α, IL-1β, COX-2, TLR4, IL-10, TGF-β1, miR-181a, miR-30d, miR-155, and miR-148, as well as the protein expression of MyD88, p-IKKα, p-IκBα, p-NF-κB p65, and iNOS, involved in this signaling pathway. In addition, the immunofluorescence assay results revealed that these samples could block the LPS-mediated nuclear translocation of the p65 protein and displayed the same function as the NF-κB inhibitor BAY 11-7082. It was concluded that CH could be endowed with higher anti-inflammatory activity to the macrophages by performing a plastein reaction, particularly that in the presence of exogenous Hyp.

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Section: Discussionmentioning

confidence: 99%

Impact of the Plastein Reaction of Casein Hydrolysates in the Presence of Exogenous Amino Acids on Their Anti-Inflammatory Effect in the Lipopolysaccharide-Stimulated Macrophages

Shi

Zhao

2022

Foods

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“…Bioactive peptides are nitrogen and amino acid sources and possess properties such as immunomodulatory, antibacterial, antithrombotic, antihypertensive, and neuroprotective effects [259][260][261][262].…”

Section: Aminoacids Peptides and Protein Hydrolysatesmentioning

confidence: 99%

Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review

et al. 2022

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Currently, there is no known cure for neurodegenerative disease. However, the available therapies aim to manage some of the symptoms of the disease. Human neurodegenerative diseases are a heterogeneous group of illnesses characterized by progressive loss of neuronal cells and nervous system dysfunction related to several mechanisms such as protein aggregation, neuroinflammation, oxidative stress, and neurotransmission dysfunction. Neuroprotective compounds are essential in the prevention and management of neurodegenerative diseases. This review will focus on the neurodegeneration mechanisms and the compounds (proteins, polyunsaturated fatty acids (PUFAs), polysaccharides, carotenoids, phycobiliproteins, phenolic compounds, among others) present in seaweeds that have shown in vivo and in vitro neuroprotective activity. Additionally, it will cover the recent findings on the neuroprotective effects of bioactive compounds from macroalgae, with a focus on their biological potential and possible mechanism of action, including microbiota modulation. Furthermore, gastrointestinal digestion, absorption, and bioavailability will be discussed. Moreover, the clinical trials using seaweed-based drugs or extracts to treat neurodegenerative disorders will be presented, showing the real potential and limitations that a specific metabolite or extract may have as a new therapeutic agent considering the recent approval of a seaweed-based drug to treat Alzheimer’s disease.

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“…e) Neuroprotective peptides-Some peptides can help maintain a healthy brain by contributing to the maintenance of cognitive functions, which would be an important factor in preventing the cognitive impairment or dementia, debilitating age-related disorders. Considering that brain neurogenesis decreases during ageing, peptides that induced proliferation and increased survival and maturation of neural progenitor cells into neurons could prevent age-related cognitive decline [25].…”

Section: C)mentioning

confidence: 99%

Food Proteins as a Tool in Human Longevity: A Mini-Review

Tavano

Júnior

2019

NTNF

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Demographic transition and interest in human longevity increasingly guide studies on the best quality of the human diet, a factor directly related to the lifespan. As the world's population is aging, with more people over 65, dietary recommendations specific to this context should be discussed and adopted. Proteins are related to this theme both for their fundamental role as nutrients, but also as nutraceutical potentials that act not only for the maintenance of health, but for the prolongation of life. Thus, there is also a growing interest in research on the effects of ingestion of peptides with different bioactivities.

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Emerging roles of bioactive peptides on brain health promotion

Cited by 19 publications

References 65 publications

Impact of the Plastein Reaction of Casein Hydrolysates in the Presence of Exogenous Amino Acids on Their Anti-Inflammatory Effect in the Lipopolysaccharide-Stimulated Macrophages

Impact of the Plastein Reaction of Casein Hydrolysates in the Presence of Exogenous Amino Acids on Their Anti-Inflammatory Effect in the Lipopolysaccharide-Stimulated Macrophages

Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review

Food Proteins as a Tool in Human Longevity: A Mini-Review

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