Emerging roles for high‐density lipoproteins in neurodegenerative disorders

Bahrami, Afsane; Barreto, George E.; Lombardi, Gemma; Pirro, Matteo; Sahebkar, Amirhossein

doi:10.1002/biof.1541

Cited by 30 publications

(17 citation statements)

References 191 publications

(394 reference statements)

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“…Small HDL-C particles are able to enter into the brain, and they also circulate in the peripheral blood. As the only lipoprotein in CSF, HDL has been found to regulate intracellular cholesterol homeostasis and amyloid protein metabolism in the brain (Bahrami et al, 2019). In this study, we identified that HDL-C levels were negatively associated with AD, which is consistent with the previous finding that higher levels of HDL may reduce the risk of the late-onset AD (Reitz et al, 2010).…”

Section: Discussionsupporting

confidence: 91%

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Revealing a Novel Landscape of the Association Between Blood Lipid Levels and Alzheimer's Disease: A Meta-Analysis of a Case-Control Study

Tang

Wang

Yang

et al. 2020

Front. Aging Neurosci.

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Objectives: Blood lipid profiles have been ambiguously reported as biomarkers of AD in recent years. This study was conducted to evaluate the correlation between blood lipid levels and AD in later-life and to explore the effectiveness and reliability of blood lipid profiles as biomarkers of AD. Methods: Database searching was conducted using PubMed, the Cochrane Library, EMBASE, and Medline. This study was designed following the Meta-analysis of Observational Studies in Epidemiology (MOOSE) criteria. Review Manager 5.3 (RevMan 5.3) software was adopted to perform meta-analysis evaluating the standard mean difference (SMD) with its 95% confidence intervals (CI). Results: A total of 5,286 participants were enrolled from 27 case-control studies in this meta-analysis. The pooled results demonstrated that total cholesterol (TC) level was significantly associated with AD in late-life (SMD = 0.17, 95% CI: [0.01, 0.32], P = 0.03), especially in the subgroup under 70 years old (SMD: 0.45, 95% CI: [0.11, 0.79], P = 0.01) and the subgroup of Western population (SMD: 0.29, 95% CI: [0.04, 0.53], P = 0.02). In the subgroup under 70 years old, the high-density lipoprotein cholesterol (HDL-C) level (SMD = −0.50, 95% CI: [−0.76, −0.25], P = 0.0001) and the low-density lipoprotein cholesterol (LDL-C) level (SMD = 0.59, 95% CI: [0.02, 1.16], P = 0.04) in the AD group were significantly lower and higher than in the control group, respectively. In the subgroup with a sample size larger than 100 subjects, the LDL-C level was significantly higher in AD patients than in the control elderly group (SMD = 0.31, 95% CI: [0.05, 0.56], P = 0.02). There was no significant association between triglyceride (TG) levels and AD in later-life (SMD = −0.00, 95% CI: [−0.12, 0.12], P = 1.00). Tang et al. Association Between Lipids and AD Conclusion: TC can be a new predictive biomarker of AD or cognitive decline in later-life. Increased TC levels are found to be associated with an elevated risk of AD. Decreased HDL-C levels and increased LDL-C levels may relate to an elevated risk of AD in subjects aged 60-70. Further comprehensive researches will be necessary in the future.

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Section: Discussionsupporting

confidence: 91%

“…On the other hand, decreased HDL-C levels may reduce the risk of cardiovascular and cerebrovascular diseases (CVD) as well as the development of AD or vascular dementia. Meanwhile, HDL-C deficiency had been identified to contribute to cognitive impairment by affecting the risk of atherosclerosis (Bahrami et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Revealing a Novel Landscape of the Association Between Blood Lipid Levels and Alzheimer's Disease: A Meta-Analysis of a Case-Control Study

Tang

Wang

Yang

et al. 2020

Front. Aging Neurosci.

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“…Underscoring the signalling potential of lipoproteins, low-density lipoproteins isolated from eCSF are responsible, to a significant extent, for neurogenic activity of the eCSF [148]. On the other hand, changed levels of high-density lipoproteins in CSF were linked to the pathophysiology of various neurodegenerative diseases [149]. In the recent years, several morphogens produced by the CPe were identified to associate directly with lipoproteins, including SHH [63,150], FGFs [98,151], or Wnts [62].…”

Section: Lipoprotein Complexes In Cp-csf Signallingmentioning

confidence: 99%

Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS

Kaiser

Bryja

2020

IJMS

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Cerebrospinal fluid (CSF) is the liquid that fills the brain ventricles. CSF represents not only a mechanical brain protection but also a rich source of signalling factors modulating diverse processes during brain development and adulthood. The choroid plexus (CP) is a major source of CSF and as such it has recently emerged as an important mediator of extracellular signalling within the brain. Growing interest in the CP revealed its capacity to release a broad variety of bioactive molecules that, via CSF, regulate processes across the whole central nervous system (CNS). Moreover, CP has been also recognized as a sensor, responding to altered composition of CSF associated with changes in the patterns of CNS activity. In this review, we summarize the recent advances in our understanding of the CP as a signalling centre that mediates long-range communication in the CNS. By providing a detailed account of the CP secretory repertoire, we describe how the CP contributes to the regulation of the extracellular environment—in the context of both the embryonal as well as the adult CNS. We highlight the role of the CP as an important regulator of CNS function that acts via CSF-mediated signalling. Further studies of CP–CSF signalling hold the potential to provide key insights into the biology of the CNS, with implications for better understanding and treatment of neuropathological conditions.

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“…Heat stress affects intestinal bacterial composition [20] and damages intestinal barrier integrity, increasing intestinal permeability, "leaky gut" [21,22], and consequently leading to elevated systemic lipopolysaccharide (LPS) levels [23]. Toxemia further causes neuroinflammation with neurological disorders and related emotional and mental damage [24,25].…”

Section: Introductionmentioning

confidence: 99%

Effect of a Synbiotic Supplement on Fear Response and Memory Assessment of Broiler Chickens Subjected to Heat Stress

Mohammed

Mahmoud

Murugesan³

et al. 2021

Animals

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The aim of this study was to evaluate the effect of a synbiotic containing a probiotic (Enterococcus faecium, Pediococcus acidilactici, Bifidobacterium animalis, and Lactobacillus reuteri) and a prebiotic (fructooligosaccharides) on fear response, memory assessment, and selected stress indicators in broilers subjected to heat stress. A total of 360 1-day-old Ross 708 chicks were evenly divided among three treatments: a basal diet mixed with a synbiotic at 0 (G-C), 0.5 (G-0.5X), and 1.0 (G-1.0X) g/kg. After 15 d, the broilers were exposed to 32 °C for 9 h daily until 42 d. The object memory test was conducted at 15 day; touch, novel object, and isolation tests were conducted at 35 day; tonic immobility (TI) took place at 41 day. At 42 day, plasma corticosterone and tryptophan concentrations and heterophile/lymphocyte (H/L) ratios were measured. Compared to controls, synbiotic-fed broilers, regardless of concentration, had a shorter latency to make the first vocalization, with higher vocalization rates during the isolation test (p = 0.001). the G-1.0 group had the lowest H/L ratio (p = 0.001), but higher plasma tryptophan concentrations and a greater number of birds could reach the observer during the touch test (p = 0.001 and 0.043, respectively). The current results indicate that the synbiotic can be used as a growth promoter to reduce the fear response and stress state of heat-stressed broilers.

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Emerging roles for high‐density lipoproteins in neurodegenerative disorders

Cited by 30 publications

References 191 publications

Revealing a Novel Landscape of the Association Between Blood Lipid Levels and Alzheimer's Disease: A Meta-Analysis of a Case-Control Study

Revealing a Novel Landscape of the Association Between Blood Lipid Levels and Alzheimer's Disease: A Meta-Analysis of a Case-Control Study

Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS

Effect of a Synbiotic Supplement on Fear Response and Memory Assessment of Broiler Chickens Subjected to Heat Stress

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