Emerging role of ZBTB7A as an oncogenic driver and transcriptional repressor

Gupta, Sanjay; Singh, Atul Kumar; Prajapati, Kumari Sunita; Kushwaha, Prem Prakash; Shuaib, Mohd; Kumar, Shashank

doi:10.1016/j.canlet.2020.04.015

Cited by 37 publications

(37 citation statements)

References 115 publications

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“…The function of ZBTB7A in the tumor is controversial and accumulating evidence indicates that ZBTB7A regulates several cell survival, differentiation and death signaling in diverse types of cancers [ 5 , 25 ]. Previous studies showed that ZBTB7A suppressed tumorigenesis in melanoma and prostate cancer [ 13 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…The zinc finger and BTB domain-containing 7A (ZBTB7A), also referred to as Pokemon (POK), LRF (lymphoma-related factor), or FBI-1 (factor binding IST protein 1), is a transcription factor that is a member of the POK family. ZBTB7A is a transcriptional regulator that binds with DNA via its zinc-finger domains [ 5 , 6 ]. According to previous research, ZBTB7A may act as an oncogene or tumor suppressor in a variety of malignancies, depending on the type and genetic context of cancer.…”

Section: Introductionmentioning

confidence: 99%

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ZBTB7A, a miR-144-3p targeted gene, accelerates bladder cancer progression via downregulating HIC1 expression

Liu

Chou

et al. 2022

Cancer Cell Int

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Background Zinc finger and BTB domain-containing 7A (ZBTB7A) is a member of the POK family of transcription factors that plays an oncogenic or tumor-suppressive role in different cancers depending on the type and genetic context of cancer. However, the function and molecular mechanism of ZBTB7A in bladder cancer (BC) remain elusive. Methods The role of ZBTB7A in bladder cancer was detected by colony formation, transwell, and tumor formation assays. The expression levels of ZBTB7A, HIC1, and miR-144-3p were analyzed by qRT-PCR and Western blot. Bioinformatics analysis and a dual-luciferase reporter assay were used to assess the effect of ZBTB7A on the promoter activity of HIC1. Results The present study revealed that knockdown of ZBTB7A suppressed BC cell growth and migration, as indicated by an approximately 50% reduction in the number of colonies and an approximately 70% reduction in the number of migrated cells. Loss of ZBTB7A inhibited tumor growth in vivo, resulting in a 75% decrease in tumor volume and an 80% decrease in tumor weight. Further mechanistic studies revealed that ZBTB7A bound to the hypermethylated in cancer 1 (HIC1) promoter and downregulated HIC1 expression, accelerating the malignant behavior of BC. Increased expression of ZBTB7A in BC tissues was negatively corrected with the expression of HIC1. Moreover, ZBTB7A was a target of miR-144-3p, which decreased ZBTB7A expression in BC. Conclusion Our data demonstrate that ZBTB7A, a targeted gene of miR-144-3p, promoted tumorigenesis of BC through downregulating HIC1 expression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ZBTB7A, a miR-144-3p targeted gene, accelerates bladder cancer progression via downregulating HIC1 expression

Liu

Chou

et al. 2022

Cancer Cell Int

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“…The POK transcription repressors (also named POZ-ZF transcription factors) are a major family of transcription factors which have a dual role in development and cancer. Apart from their involvement in several fundamental biological processes, they also participate in hematopoiesis, adipogenesis, chondrogenesis, DNA repair, development of oligodendrocytes, osteoclast, and unfolded protein response ( 209 ). The POK family (present in approximately 43 human genes) is composed of one or more C-terminal C 2 H 2 Krüppel -type zinc finger domains, which are DNA binding domains, coupled with an N-terminal POZ/BTB (broad-complex, tramtrack, and Bric a brac) domain used for protein–protein interactions, allowing recruitment of corepressor complexes.…”

Section: Pok Familymentioning

confidence: 99%

Transcription Factors: The Fulcrum Between Cell Development and Carcinogenesis

et al. 2021

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Higher eukaryotic development is a complex and tightly regulated process, whereby transcription factors (TFs) play a key role in controlling the gene regulatory networks. Dysregulation of these regulatory networks has also been associated with carcinogenesis. Transcription factors are key enablers of cancer stemness, which support the maintenance and function of cancer stem cells that are believed to act as seeds for cancer initiation, progression and metastasis, and treatment resistance. One key area of research is to understand how these factors interact and collaborate to define cellular fate during embryogenesis as well as during tumor development. This review focuses on understanding the role of TFs in cell development and cancer. The molecular mechanisms of cell fate decision are of key importance in efforts towards developing better protocols for directed differentiation of cells in research and medicine. We also discuss the dysregulation of TFs and their role in cancer progression and metastasis, exploring TF networks as direct or indirect targets for therapeutic intervention, as well as specific TFs’ potential as biomarkers for predicting and monitoring treatment responses.

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“…BCSCs play an important role in cancer metastasis due to the aberrant expression of some stemness-related factors, such as CD44, SOX2, OCT4, c-MYC, KLF4, Nanog, and SALL4 [ 2 , 3 ]. Besides the high expression of stemness and self-renewal markers, the aberrant expression of molecular signaling pathways including Wnt/β-catenin, Notch, Hedgehog, JAK-STAT, and PI3K/Akt/mTOR in BCSCs are shown to be involved in the pathophysiology of the disease [ 4 , 5 ]. Overall, the present literature reveals that the occurrence of BCSCs in the tumor microenvironment positively correlates with disease recurrence, low survival rate, chemo/radio therapy resistance, and low therapeutic output [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment

Prajapati

Gupta

Kumar

2022

Cancers

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Breast cancer is heterogeneous disease with variable prognosis and therapeutic response. Approximately, 70% of diagnosed breast cancer represents the luminal A subtype. This subpopulation has a fair prognosis with a lower rate of relapse than the other clinical subtypes. Acquisition of stemness in luminal A subtype modifies the phenotype plasticity to accomplish increased aggressiveness and therapeutic resistance. Therefore, targeting luminal A-derived breast cancer stem cells (BCSCs) could be a promising strategy for its prevention and treatment. Extensive studies reveal that dietary phytochemicals have the potential to target BCSCs by modulating the molecular and signal transduction pathways. Dietary phytochemicals alone or in combination with standard therapeutic modalities exert higher efficacy in targeting BCSCs through changes in stemness, self-renewal properties and hypoxia-related factors. These combinations offer achieving higher radio- and chemo- sensitization through alteration in the key signaling pathways such as AMPK, STAT3, NF-ĸB, Hedgehog, PI3K/Akt/mTOR, Notch, GSK3β, and Wnt related to cancer stemness and drug resistance. In this review, we highlight the concept of targeting luminal A-derived BCSCs with dietary phytochemicals by summarizing the pathways and underlying mechanism(s) involved during therapeutic resistance.

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Emerging role of ZBTB7A as an oncogenic driver and transcriptional repressor

Cited by 37 publications

References 115 publications

ZBTB7A, a miR-144-3p targeted gene, accelerates bladder cancer progression via downregulating HIC1 expression

ZBTB7A, a miR-144-3p targeted gene, accelerates bladder cancer progression via downregulating HIC1 expression

Transcription Factors: The Fulcrum Between Cell Development and Carcinogenesis

Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment

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