Emerging role of nutrition and the non-coding landscape in type 2 diabetes mellitus: A review of literature

Matboli, Marwa; Shafei, Ayman; Ali, Mahmoud; Kamal, Kamal M; Noah, Mahmoud; Lewis, P.; Habashy, Abdulrahman; Ehab, Mohamed; Gaber, Ahmed I.; Abdelzaher, Hana Mahmoud

doi:10.1016/j.gene.2018.06.082

Cited by 7 publications

(4 citation statements)

References 70 publications

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“…Approximately 400 million people around the world live with type 2 diabetes mellitus, a chronic disease that causes almost 5 million deaths each year. It is expected that the number of people with type 2 diabetes will reach 640 million by 2040 (Matboli et al, 2018;Cheng et al, 2019). Complications of diabetes include retinopathy, nephropathy, and cardiovascular disease, and they pose serious risks for people with type 2 diabetes (Parsamanesh et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Identification of novel peptides from goat milk casein that ameliorate high-glucose-induced insulin resistance in HepG2 cells

Gong

Gao

Wang

et al. 2020

Journal of Dairy Science

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In this study, we investigated the effect of goat milk casein hydrolysates on glucose consumption rate, intracellular glycogen concentration, and mRNA expression of gluconeogenesis-related genes, including phosphoenolpyruvate carboxykinase 1 (PCK1) and glucose-6-phosphatase catalytic subunit (G6PC), in insulinresistant HepG2 cells. From the obtained hydrolysates, we also purified and characterized novel peptides that ameliorated high-glucose-induced insulin resistance in HepG2 cells. The 3-h hydrolysate caused the highest glucose consumption rate in insulin-resistant HepG2 cells. It also showed positive effects on promoting intracellular glycogenesis and reducing mRNA expression of PCK1 and G6PC. We separated the obtained hydrolysates into 3 fractions (F1, F2, and F3) by gel filtration chromatography; we further purified F1 using reversedphase HPLC and identified peptides using liquid chromatography-tandem mass spectrometry. The bioactive peptides identified were SDIPNPIGSE (α S1 -casein, f195-204), NPWDQVKR (α S2 -casein, f123-130), SLSS-SEESITH (β-casein, f30-40), and QEPVLGPVRGPFP (β-casein, f207-219). Our findings indicated that specific bioactive peptides from goat milk casein hydrolysates ameliorated insulin resistance in HepG2 cells that had been treated with high glucose. This is a first step toward determining whether goat milk casein hydrolysates can be used as food ingredients to ameliorate insulin resistance.

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Section: Introductionmentioning

confidence: 99%

Identification of novel peptides from goat milk casein that ameliorate high-glucose-induced insulin resistance in HepG2 cells

Gong

Gao

Wang

et al. 2020

Journal of Dairy Science

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“…In other words, the genotype of an organism remains intact while the outward expression (phenotype) is altered. In this regard, nutrition, stress, and lifestyle choices are some factors that contribute to epigenetic changes22 with non-Mendelian inheritance patterns 23. At the molecular level, three major types of mechanisms drive epigenetics: non-coding RNAs (ncRNAs), histone modifications such as acetylation, and DNA methylation 23…”

Section: Introductionmentioning

confidence: 99%

<p>Could epigenetics help explain racial disparities in chronic pain?</p>

Aroke

Joseph

Roy

et al. 2019

JPR

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African Americans disproportionately suffer more severe and debilitating morbidity from chronic pain than do non-Hispanic Whites. These differences may arise from differential exposure to psychosocial and environmental factors such as adverse childhood experiences, racial discrimination, low socioeconomic status, and depression, all of which have been associated with chronic stress and chronic pain. Race, as a social construct, makes it such that African Americans are more likely to experience different early life conditions, which may induce epigenetic changes that sustain racial differences in chronic pain. Epigenetics is one mechanism by which environmental factors such as childhood stress, racial discrimination, economic hardship, and depression can affect gene expression without altering the underlying genetic sequence. This article provides a narrative review of the literature on epigenetics as a mechanism by which differential environmental exposure could explain racial differences in chronic pain. Most studies of epigenetic changes in chronic pain examine DNA methylation. DNA methylation is altered in the glucocorticoid (stress response) receptor gene, NR3C1 , which has been associated with depression, childhood stress, low socioeconomic status, and chronic pain. Similarly, DNA methylation patterns of immune cytokine genes have been associated with chronic stress states. Thus, DNA methylation changes may play an essential role in the epigenetic modulation of chronic pain in different races with a higher incidence of epigenetic alterations contributing to more severe and disabling chronic pain in African Americans.

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“…Recently, Tong et al [ 24 ] identified 184 lncRNAs (intergenic) in the bovine mammary gland including 36 lincRNAs co-located with 172 milk related quantitative trait loci (QTL) and one lncRNA co-located within a mastitis QTL region. Moreover, lncRNAs have been shown to play roles in dietary response in different species including human [ 38 , 39 , 40 ], mouse [ 41 ], pig [ 42 ] and calf [ 43 ]. LncRNA roles in dietary responses might be through various processes such as metabolic control [ 40 ], glucose homeostasis [ 40 ] or hypoxia-mediated metastasis [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Analysis of Long Non-Coding RNA in the Bovine Mammary Gland Following Dietary Supplementation with Linseed Oil and Safflower Oil

Ibeagha‐Awemu

Dudemaine

et al. 2018

IJMS

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This study aimed to characterize the long non-coding RNA (lncRNA) expression in the bovine mammary gland and to infer their functions in dietary response to 5% linseed oil (LSO) or 5% safflower oil (SFO). Twelve cows (six per treatment) in mid lactation were fed a control diet for 28 days followed by a treatment period (control diet supplemented with 5% LSO or 5% SFO) of 28 days. Mammary gland biopsies were collected from each animal on day-14 (D-14, control period), D+7 (early treatment period) and D+28 (late treatment period) and were subjected to RNA-Sequencing and subsequent bioinformatics analyses. Functional enrichment of lncRNA was performed via potential cis regulated target genes located within 50 kb flanking regions of lncRNAs and having expression correlation of >0.7 with mRNAs. A total of 4955 lncRNAs (325 known and 4630 novel) were identified which potentially cis targeted 59 and 494 genes in LSO and SFO treatments, respectively. Enrichments of cis target genes of lncRNAs indicated potential roles of lncRNAs in immune function, nucleic acid metabolism and cell membrane organization processes as well as involvement in Notch, cAMP and TGF-β signaling pathways. Thirty-two and 21 lncRNAs were differentially expressed (DE) in LSO and SFO treatments, respectively. Six genes (KCNF1, STARD13, BCL6, NXPE2, HHIPL2 and MMD) were identified as potential cis target genes of six DE lncRNAs. In conclusion, this study has identified lncRNAs with potential roles in mammary gland functions and potential candidate genes and pathways via which lncRNAs might function in response to LSO and SFA.

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Emerging role of nutrition and the non-coding landscape in type 2 diabetes mellitus: A review of literature

Cited by 7 publications

References 70 publications

Identification of novel peptides from goat milk casein that ameliorate high-glucose-induced insulin resistance in HepG2 cells

Identification of novel peptides from goat milk casein that ameliorate high-glucose-induced insulin resistance in HepG2 cells

<p>Could epigenetics help explain racial disparities in chronic pain?</p>

Transcriptome Analysis of Long Non-Coding RNA in the Bovine Mammary Gland Following Dietary Supplementation with Linseed Oil and Safflower Oil

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