Emerging role of neuregulin as a modulator of muscle metabolism

Abstract

Gumà A, Martínez-Redondo V, López-Soldado I, Cantó C, Zorzano A. Emerging role of neuregulin as a modulator of muscle metabolism.

Neuregulin 1 improves glucose tolerance in adult and old rats

“…Although most studies of NRG1 have focused on its myogenic and neurotrophic properties, it has been suggested that NRG1 can also influence glucose metabolism [5], particularly in skeletal muscle, the major site of insulin-stimulated glucose disposal. For instance, NRG1 increases glucose uptake in L6E9 myotubes and isolated strips of soleus muscle [9].…”

Altered Gene Expression Pathways in Duchenne Muscular Dystrophy

“…Neuregulin-1 (NRG-1) was initially described as a neurotrophic factor involved in neuromuscular junction formation in skeletal muscle, but recently it has emerged as a myokine, with relevant effects on myogenesis, muscle metabolism and regeneration, and has been considered as a strong candidate to transduce muscle adaptation to chronic exercise (Lebrasseur et al 2003;Guma et al 2010). …”

Species-specific effects of neuregulin-1β (cimaglermin alfa) on glucose handling in animal models and humans with heart failure

“…NRG 1 binds to tyrosine kinase receptors ErbB3 and ErbB4, which form homodimers or ErbB2 heterodimers. Dimerization induces ErbB receptor phosphorylation, activating a number of downstream intracellular signaling proteins via multiple mechanisms including PI3K-Akt and MAPK/ERK pathways (Carraway and Cantley, 1994, Yarden and Sliwkowski, 2001, Gumà et al, 2010). These signaling cascades affect transcription of a number of gene products that are essential for growth, differentiation and survival of the heart and nervous system (Falls, 2003).…”

“…In addition to playing an important role in cardiac function, NRG 1β is involved in the regulation of glucose metabolism (Gumà, et al, 2010; Ennequin et al, 2015; Caillaud, et al, 2016). NRG 1β can influence glucose homeostasis through effects on the translocation of glucose transporters in rat L6E9 myoblasts (Suárez et al, 2001).…”